A Hybrid Stimulation Strategy for Suppression of Spiral

Abstract 8 Atrial brillation (AF) is the most common cardiac arrhythmia whose me- 9 chanisms are thought to be mainly due to the self perpetuation of spiral waves 10 (SW). To date, available treatment strategies (antiarrhythmic drugs, radiofre- 11 quency ablation of the substrate, electrical cardioversion) to restore and to 12 maintain a normal sinus rhythm have limitations and are associated with AF 13 recurrences. The aim of this study was to assess a way of suppressing SW by 14 applying multifocal electrical stimulations in a simulated cardiac tissue using 15 a 2D FitzHugh-Nagumo model specially convenient for AF investigations. We 16 identied stimulation parameters for successful termination of SW. However, 17 SW reinduction, following the electrical stimuli, leads us to develop a hybrid 18 strategy based on sodium channel modication for the simulated tissue. 19 Version : 175 20 15 avril 2011, 11:18:50 Email addresses: sjacquir@u-bourgogne.fr (Sabir Jacquir), stbinc@u-bourgogne.fr (StA©phane Binczak)Preprint submitted to Elsevier 15 avril 2011

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