Chinese dyslexics show neural differences in morphological processing

Previous behavioral studies have suggested that morphological awareness is impaired in Chinese children with reading disability (RD), but how this is reflected in brain alterations is not known. Using functional magnetic resonance imaging (fMRI), the current study compared morphological processing in a RD group (11-13 years old) to an age-matched typically developing (TD) group. Participants made semantic relatedness judgments to incongruent word pairs that were either semantically related but did not share a morpheme or semantically unrelated but did share a morpheme. This was compared to conditions where semantic relatedness and morphemic information was congruent. A smaller incongruency effect was found in left dorsal posterior (BA9) and ventral anterior (BA47) inferior frontal gyrus (IFG) in the RD compared to the TD, suggesting that the RD is less sensitive to morphological information. This was a specific deficit as a phonological control task that manipulated congruency between orthography and phonology did not show group differences in the IFG. Moreover, brain activation in the IFG for the incongruency effect in the semantic task was negatively correlated with reading skill for the RD group only, suggesting that higher skill children with RD may rely on a compensatory whole-word strategy by ignoring the morphemic information.

[1]  W. Kaiser,et al.  fMRI during word processing in dyslexic and normal reading children. , 1999, Neuroreport.

[2]  Zhang Xue-xi,et al.  Meaning-spelling Theory of the Chinese Characters:Insight into the Nature of Written Chinese from the Perspective of Cognitive Psychology , 2011 .

[3]  D. Burman,et al.  Deficient orthographic and phonological representations in children with dyslexia revealed by brain activation patterns. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[4]  W. F. Vonderhaar.  A COMPARATIVE STUDY OF PERFORMANCE SCALE IQ'S AND SUBTEST SCORES OF DEAF CHILDREN ON THE WECHSLER INTELLIGENCE SCALE FOR CHILDREN AND THE WECHSLER INTELLIGENCE SCALE FOR CHILDREN-REVISED , 1977 .

[5]  M. Just,et al.  From the Selectedworks of Marcel Adam Just Neural Basis of Dyslexia: a Comparison between Dyslexic and Non-dyslexic Children Equated for Reading Ability Neural Basis of Dyslexia: a Comparison between Dyslexic and Nondyslexic Children Equated for Reading Ability , 2022 .

[6]  David Badre,et al.  Left ventrolateral prefrontal cortex and the cognitive control of memory , 2007, Neuropsychologia.

[7]  M. Tainturier,et al.  Inflectional spelling deficits in developmental dyslexia , 2011, Cortex.

[8]  William D. Marslen-Wilson,et al.  Words, Morphemes, and Syllables in the Chinese Mental Lexicon. , 1994 .

[9]  Nadia E. Cone,et al.  Neural correlates of orthographic and phonological consistency effects in children , 2008, Human brain mapping.

[10]  William D. Marslen-Wilson,et al.  Differentiating Morphology, Form, and Meaning: Neural Correlates of Morphological Complexity , 2007, Journal of Cognitive Neuroscience.

[11]  Martin Kronbichler,et al.  Meta-analyzing brain dysfunctions in dyslexic children and adults , 2011, NeuroImage.

[12]  Bruce D. McCandliss,et al.  Neural systems predicting long-term outcome in dyslexia , 2010, Proceedings of the National Academy of Sciences.

[13]  J. Gabrieli,et al.  Functional and morphometric brain dissociation between dyslexia and reading ability , 2007, Proceedings of the National Academy of Sciences.

[14]  Evan M. Gordon,et al.  Developmental cognitive neuroscience , 2011, Developmental Cognitive Neuroscience.

[15]  John C Gore,et al.  Neural systems for compensation and persistence: young adult outcome of childhood reading disability , 2003, Biological Psychiatry.

[16]  S C Cramer,et al.  Instructional treatment associated with changes in brain activation in children with dyslexia , 2003, Neurology.

[17]  Catherine McBride-Chang,et al.  Holistic versus analytic processing: evidence for a different approach to processing of Chinese at the word and character levels in Chinese children. , 2010, Journal of experimental child psychology.

[18]  Simpson W. L. Wong,et al.  Early predictors of dyslexia in Chinese children: familial history of dyslexia, language delay, and cognitive profiles. , 2011, Journal of child psychology and psychiatry, and allied disciplines.

[19]  W. Siok,et al.  The role of phonological awareness and visual-orthographic skills in Chinese reading acquisition. , 2001, Developmental psychology.

[20]  Rachel Schiff,et al.  Effect of phonological and morphological awareness on reading comprehension in Hebrew-speaking adolescents with reading disabilities , 2011, Annals of dyslexia.

[21]  M. Raveh,et al.  Deficient morphological processing in adults with developmental dyslexia: another barrier to efficient word recognition? , 2007, Dyslexia.

[22]  C. Ho,et al.  Cognitive skills and literacy performance of Chinese adolescents with and without dyslexia , 2010, Reading and writing.

[23]  B. Pennington,et al.  Brain Structure Correlates of Component Reading Processes: Implications for Reading Disability , 2007, Cortex.

[24]  Development in children's sensitivity to the role of derivations in spelling. , 2011, Canadian journal of experimental psychology = Revue canadienne de psychologie experimentale.

[25]  James R. Booth,et al.  Similar alterations in brain function for phonological and semantic processing to visual characters in Chinese dyslexia , 2012, Neuropsychologia.

[26]  J. Fiez.  Phonology, Semantics, and the Role of the Left Inferior Prefrontal Cortex , 2022 .

[27]  M. Seghier,et al.  Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences , 2010, Brain : a journal of neurology.

[28]  James R. Booth,et al.  Differential effects of orthographic and phonological consistency in cortex for children with and without reading impairment , 2008, Neuropsychologia.

[29]  John D E Gabrieli,et al.  Prediction of children's reading skills using behavioral, functional, and structural neuroimaging measures. , 2007, Behavioral neuroscience.

[30]  M. Leikin,et al.  Morphological Processing in Adult Dyslexia , 2006, Journal of psycholinguistic research.

[31]  Wai Ting Siok,et al.  Developmental dyslexia is characterized by the co-existence of visuospatial and phonological disorders in Chinese children , 2009, Current Biology.

[32]  Simpson W. L. Wong,et al.  Word recognition and cognitive profiles of Chinese pre-school children at risk for dyslexia through language delay or familial history of dyslexia. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[33]  P. Matthews,et al.  Semantic Processing in the Left Inferior Prefrontal Cortex: A Combined Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation Study , 2003, Journal of Cognitive Neuroscience.

[34]  James R. Booth,et al.  Cultural Constraints on Brain Development: Evidence from a Developmental Study of Visual Word Processing in Mandarin Chinese , 2009, Cerebral cortex.

[35]  Richard C. Anderson,et al.  Morphological Awareness and Learning to Read: A Cross-Language Perspective , 2006 .

[36]  H. Shu,et al.  Morphological Awareness Uniquely Predicts Young Children's Chinese Character Recognition , 2003 .

[37]  Virginia A. Mann,et al.  The relation between reading ability and morphological skills: Evidence from derivational suffixes , 2000 .

[38]  E. Paulesu,et al.  When all hypotheses are right: A multifocal account of dyslexia , 2009, Human brain mapping.

[39]  Philip H. K. Seymour,et al.  Derivational morphology and spelling in dyslexia , 2006 .

[40]  Cristina Burani,et al.  Functional Anatomy of Derivational Morphology , 2006, Cortex.

[41]  C. Ho,et al.  Cognitive profiling and preliminary subtyping in Chinese developmental dyslexia , 2004, Cognition.

[42]  William D. Marslen-Wilson,et al.  Morphological Structure in the Chinese Mental Lexicon , 1995 .

[43]  Kathy Conklin,et al.  Fast Automatic Translation and Morphological Decomposition in Chinese-English Bilinguals , 2011, Psychological science.

[44]  A. Liberman,et al.  Functional disruption in the organization of the brain for reading in dyslexia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[45]  W D Marslen-Wilson,et al.  Differentiating lexical form, meaning, and structure in the neural language system. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Xiaolin Zhou,et al.  Orthographic and phonological processing in Chinese dyslexic children: An ERP study on sentence reading , 2007, Brain Research.

[47]  J. Carlisle.  Awareness of the structure and meaning of morphologically complex words: Impact on reading , 2000 .

[48]  L. Tan,et al.  Biological abnormality of impaired reading is constrained by culture , 2004, Nature.

[49]  H. Wimmer,et al.  Functional abnormalities in the dyslexic brain: A quantitative meta‐analysis of neuroimaging studies , 2009, Human brain mapping.

[50]  P. Colé,et al.  Morphological awareness in developmental dyslexia , 2004, Annals of dyslexia.

[51]  R. Poldrack,et al.  Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex , 2005, Neuron.

[52]  William D. Marslen-Wilson,et al.  Tracking speech comprehension in space and time , 2006, NeuroImage.

[53]  William D. Marslen-Wilson,et al.  Phonology and neuropsychology of the English past tense , 2002, Neuropsychologia.

[54]  William D. Marslen-Wilson,et al.  Dissociations in Processing Past Tense Morphology: Neuropathology and Behavioral Studies , 2002, Journal of Cognitive Neuroscience.

[55]  Zhendong Niu,et al.  A structural–functional basis for dyslexia in the cortex of Chinese readers , 2008, Proceedings of the National Academy of Sciences.

[56]  James R. Booth,et al.  Children with reading disorder show modality independent brain abnormalities during semantic tasks , 2007, Neuropsychologia.

[57]  William D. Marslen-Wilson,et al.  Temporal and frontal systems in speech comprehension: An fMRI study of past tense processing , 2005, Neuropsychologia.

[58]  Catherine McBride-Chang,et al.  Understanding Chinese Developmental Dyslexia: Morphological Awareness as a Core Cognitive Construct. , 2006 .

[59]  B. Shaywitz,et al.  Paying attention to reading: The neurobiology of reading and dyslexia , 2008, Development and Psychopathology.

[60]  J. Desmond,et al.  Functional Specialization for Semantic and Phonological Processing in the Left Inferior Prefrontal Cortex , 1999, NeuroImage.

[61]  R Frost,et al.  Decomposing words into their constituent morphemes: evidence from English and Hebrew. , 1995, Journal of experimental psychology. Learning, memory, and cognition.