An RNA-Based Information Superhighway in Plants

In their commentary, Jorgensen et al . propose that plants contain a mechanism designed to transfer information over long distances--similar in function to an animal9s bloodstream or nervous system. The authors integrate recent work on a phenomenon called "cosupression," in which introduced genes can suppress expression of the plant9s own genes, with other research on how plants resist viral infections and suggest that information-carrying molecules (likely RNAs) move through the plant in long tubes (phloem) and regulate cell physiology at a distance.

[1]  D. Baulcombe,et al.  Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants , 1996 .

[2]  Kathleen Y. Lee,et al.  Post‐transcriptional gene silencing of ACC synthase in tomato results from cytoplasmic RNA degradation , 1997 .

[3]  R. Jorgensen,et al.  Distinct patterns of pigment suppression are produced by allelic sense and antisense chalcone synthase transgenes in petunia flowers , 1998 .

[4]  W. Frommer,et al.  Macromolecular Trafficking Indicated by Localization and Turnover of Sucrose Transporters in Enucleate Sieve Elements , 1997, Science.

[5]  R. Jorgensen Cosuppression, Flower Color Patterns, and Metastable Gene Expression States , 1995, Science.

[6]  C. Kunz,et al.  Developmentally regulated silencing and reactivation of tobacco chitinase transgene expression , 1996 .

[7]  J. J. English,et al.  The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence. , 1997, The Plant cell.

[8]  H. Vaucheret,et al.  Frequencies, Timing, and Spatial Patterns of Co-Suppression of Nitrate Reductase and Nitrite Reductase in Transgenic Tobacco Plants , 1996, Plant physiology.

[9]  W. Dougherty,et al.  Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance. , 1993, The Plant cell.

[10]  William J Lucas,et al.  Plasmodesmata and the supracellular nature of plants. , 1993, The New phytologist.

[11]  H. Vaucheret,et al.  Systemic acquired silencing: transgene‐specific post‐transcriptional silencing is transmitted by grafting from silenced stocks to non‐silenced scions , 1997, The EMBO journal.

[12]  S. Covey,et al.  Plants combat infection by gene silencing , 1997, Nature.

[13]  R. Jorgensen,et al.  Altered gene expression in plants due to trans interactions between homologous genes. , 1990, Trends in biotechnology.

[14]  M. Metzlaff,et al.  RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia , 1997, Cell.

[15]  Olivier Voinnet,et al.  Systemic signalling in gene silencing , 1997, Nature.

[16]  W. J. Lucas,et al.  Selective Trafficking of KNOTTED1 Homeodomain Protein and Its mRNA Through Plasmodesmata , 1995, Science.

[17]  W. F. Thompson,et al.  Characterization of Post-Transcriptionally Suppressed Transgene Expression That Confers Resistance to Tobacco Etch Virus Infection in Tobacco. , 1997, The Plant cell.

[18]  J. Ryals,et al.  Systemic Acquired Resistance. , 1996, The Plant cell.

[19]  M. Van Montagu,et al.  Post-transcriptional cosuppression of beta-1,3-glucanase genes does not affect accumulation of transgene nuclear mRNA. , 1995, The Plant cell.

[20]  D. Baulcombe,et al.  A similarity between viral defense and gene silencing in plants. , 1997, Science.

[21]  J. García,et al.  Delayed Resistance to Plum Pox Potyvirus Mediated by a Mutated RNA Replicase Gene: Involvement of a Gene-Silencing Mechanism , 1997 .

[22]  W. Dougherty,et al.  Transgenes and gene suppression: telling us something new? , 1995, Current opinion in cell biology.

[23]  E. Coen,et al.  Allelic interactions at the nivea locus of Antirrhinum. , 1991, The Plant cell.

[24]  W. J. Lucas,et al.  How do viruses traffic on the ‘vascular highway’? , 1996 .