What Threshold Defines Penumbral Brain Tissue in Patients with Symptomatic Anterior Circulation Intracranial Stenosis: An Exploratory Analysis

Impaired distal perfusion predicts neurological deterioration in large artery atherosclerosis. We aim to determine the optimal threshold of Tmax delay on perfusion imaging that is associated with neurological deterioration in patients with symptomatic proximal anterior circulation large artery stenosis.

[1]  Sara K. Rostanski,et al.  Perfusion imaging and recurrent cerebrovascular events in intracranial atherosclerotic disease or carotid occlusion , 2018, International journal of stroke : official journal of the International Stroke Society.

[2]  A. Demchuk,et al.  Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging , 2018, The New England journal of medicine.

[3]  M. Chimowitz,et al.  Stroke Caused by Atherosclerosis of the Major Intracranial Arteries , 2017, Circulation research.

[4]  Sara K. Rostanski,et al.  Imaging Parameters and Recurrent Cerebrovascular Events in Patients With Minor Stroke or Transient Ischemic Attack. , 2016, JAMA neurology.

[5]  K. Thulborn,et al.  Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease. , 2016, JAMA neurology.

[6]  H. Kamel,et al.  Oxygen Extraction Fraction and Stroke Risk in Patients with Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis , 2014, American Journal of Neuroradiology.

[7]  Manabu Inoue,et al.  Early Diffusion-Weighted Imaging and Perfusion-Weighted Imaging Lesion Volumes Forecast Final Infarct Size in DEFUSE 2 , 2013, Stroke.

[8]  Mark D. Johnson,et al.  Stenting versus aggressive medical therapy for intracranial arterial stenosis. , 2011, The New England journal of medicine.

[9]  H. A. Smith,et al.  A standardized method for measuring intracranial arterial stenosis. , 2000, AJNR. American journal of neuroradiology.