Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.

[1]  Ying Sun,et al.  Targeted Deletion of Fatty Acid Transport Protein-4 Results in Early Embryonic Lethality* , 2003, Journal of Biological Chemistry.

[2]  D. Bernlohr,et al.  Characterization of the Acyl-CoA Synthetase Activity of Purified Murine Fatty Acid Transport Protein 1* , 2003, Journal of Biological Chemistry.

[3]  D. Bernlohr,et al.  FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells DOI 10.1194/jlr.M200130-JLR200 , 2002, Journal of Lipid Research.

[4]  S. Peikin,et al.  Orlistat: its current status as an anti-obesity drug. , 2002, European journal of pharmacology.

[5]  D. Bernlohr,et al.  Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. , 2001, Gene.

[6]  C. Kappe.  Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog. , 2000, Accounts of chemical research.

[7]  B. Frohnert,et al.  The Fatty Acid Transport Protein (FATP1) Is a Very Long Chain Acyl-CoA Synthetase* , 1999, The Journal of Biological Chemistry.

[8]  N. Abumrad,et al.  Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. , 1999, Biochimica et biophysica acta.

[9]  H. Lodish,et al.  Identification of the major intestinal fatty acid transport protein. , 1999, Molecular cell.

[10]  C. Kappe,et al.  Determination of absolute configuration in 4-aryl-3, 4-dihydro-2(1H)-pyrimidones by high performance liquid chromatography and CD spectroscopy. , 1999, Chirality.

[11]  N. Abumrad,et al.  Membrane transport of long-chain fatty acids: evidence for a facilitated process. , 1998, Journal of lipid research.

[12]  R. Chang,et al.  Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia , 1998 .

[13]  J. Schaffer,et al.  Substitution of Alanine for Serine 250 in the Murine Fatty Acid Transport Protein Inhibits Long Chain Fatty Acid Transport* , 1998, The Journal of Biological Chemistry.

[14]  H. Lodish,et al.  A family of fatty acid transporters conserved from mycobacterium to man. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[15]  E. Hu,et al.  Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones , 1998 .

[16]  C. Kappe.  A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate(1). , 1997, The Journal of organic chemistry.

[17]  A. de Pover,et al.  Inhibition of lipid absorption as an approach to the treatment of obesity. , 1997, Methods in enzymology.

[18]  H. Lodish,et al.  Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein , 1994, Cell.

[19]  S. Sherif,et al.  A convenient synthesis of thiazolopyrimidines, thiazolodipyrimidines and heterocyclothiazolopyrimidines , 1993 .

[20]  C. Kappe,et al.  Synthesis and reactions of biginelli compounds −5. Facile preparation and resolution of a stable 5-dihydropyrimidinecarboxylic acid. , 1992 .