Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases.

[1]  J B Renner,et al.  Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. , 1999, Arthritis and rheumatism.

[2]  E. Thonar,et al.  Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest. , 1999, Arthritis and rheumatism.

[3]  Frederick Albert Matsen IV,et al.  Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage. , 1999, Arthritis and rheumatism.

[4]  J. Johansen,et al.  Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. , 1999, Rheumatology.

[5]  R. Wynn,et al.  Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. , 1999, Science.

[6]  P. Delmas,et al.  Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products. , 1999, Bone.

[7]  A. Poole,et al.  Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. , 1999, Arthritis and rheumatism.

[8]  H. Nielsen,et al.  Serum YKL-40 and colorectal cancer , 1999, British Journal of Cancer.

[9]  G. Burmester,et al.  Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers. , 1999, The Journal of rheumatology.

[10]  N. Ishiguro,et al.  Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis. , 1999, Arthritis and rheumatism.

[11]  R. Moskowitz,et al.  Changes in serum cartilage marker levels indicate altered cartilage metabolism in families with the osteoarthritis-related type II collagen gene COL2A1 mutation. , 1999, Arthritis and rheumatism.

[12]  P. Dieppe,et al.  Evidence for altered synthesis of type II collagen in patients with osteoarthritis. , 1998, The Journal of clinical investigation.

[13]  D. Heinegård,et al.  Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid. , 1998, Arthritis and rheumatism.

[14]  H. Watanabe,et al.  Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. , 1998, Journal of biochemistry.

[15]  E. Vignon,et al.  Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: A one year prospective study , 1998, Annals of the rheumatic diseases.

[16]  D. Heinegård,et al.  Cartilage Oligomeric Matrix Protein Shows High Affinity Zinc-dependent Interaction with Triple Helical Collagen* , 1998, The Journal of Biological Chemistry.

[17]  D. Taylor,et al.  Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis. , 1998, Arthritis and rheumatism.

[18]  C. White,et al.  Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes. , 1998, Arthritis and rheumatism.

[19]  P. Delmas,et al.  BIOCHEMICAL MARKERS OF BONE TURNOVER: Applications For Osteoporosis , 1998 .

[20]  H. Iwata,et al.  Synovial fluid cartilage metabolism marker concentrations in osteonecrosis of the femoral head compared with osteoarthrosis of the hip. , 1998, The Journal of rheumatology.

[21]  J. O'dell,et al.  Chondrex: new marker of joint disease. , 1998, Clinical chemistry.

[22]  G. Müller,et al.  COMP (cartilage oligomeric matrix protein) is synthesized in ligament, tendon, meniscus, and articular cartilage. , 1998, Connective tissue research.

[23]  J. Mudgett,et al.  Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. , 1998, Arthritis and rheumatism.

[24]  D. Heinegård,et al.  Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. , 1998, British journal of rheumatology.

[25]  D. Heinegård,et al.  Bone scan and serum markers of bone and cartilage in patients with knee pain and osteoarthritis. , 1998, Osteoarthritis and cartilage.

[26]  A. Cole,et al.  Osteoarthritic lesions: involvement of three different collagenases. , 1997, Arthritis and rheumatism.

[27]  T. Saxne,et al.  Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: relationship to development of joint destruction in hands and feet. , 1997, British journal of rheumatology.

[28]  R. Midura,et al.  Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan* , 1997, The Journal of Biological Chemistry.

[29]  T. Saxne,et al.  HLA DRB1* typing and cartilage oligomeric matrix protein (COMP) as predictors of joint destruction in recent-onset rheumatoid arthritis. , 1997, British journal of rheumatology.

[30]  S. Coulter,et al.  A Human-specific Polymorphism in the Coding Region of the Aggrecan Gene , 1997, The Journal of Biological Chemistry.

[31]  T. Spector,et al.  Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. , 1997, Arthritis and rheumatism.

[32]  C. Rorabeck,et al.  Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. , 1997, The Journal of clinical investigation.

[33]  M. Paulsson,et al.  Increased degradation and alteered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[34]  K. Eberhardt,et al.  Development of radiographic damage during the first 5-6 yr of rheumatoid arthritis. A prospective follow-up study of a Swedish cohort. , 1996, British journal of rheumatology.

[35]  H. Roos,et al.  Procollagen II C-propeptide in joint fluid: changes in concentration with age, time after knee injury, and osteoarthritis. , 1996, The Journal of rheumatology.

[36]  P. Dieppe,et al.  The relevance of chondroitin and keratan sulphate markers in normal and arthritic synovial fluid. , 1996, British journal of rheumatology.

[37]  F. Reinholt,et al.  Bone Sialoprotein and Osteopontin Distribution at the Osteocartilaginous Interface , 1996, Clinical orthopaedics and related research.

[38]  M. Aebi,et al.  The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. , 1996, The Journal of clinical investigation.

[39]  T. Laurent,et al.  Serum hyaluronan as a disease marker. , 1996, Annals of medicine.

[40]  V. Backer,et al.  Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. , 1996, British journal of rheumatology.

[41]  K. Kushida,et al.  Concentrations of pyridinoline and deoxypyridinoline in joint tissues from patients with osteoarthritis or rheumatoid arthritis. , 1996, Annals of the rheumatic diseases.

[42]  J. Pelletier,et al.  The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. , 1996, The Journal of clinical investigation.

[43]  K. Geoghegan,et al.  Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. , 1996, The Journal of clinical investigation.

[44]  J. Johansen,et al.  Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. , 1995, European journal of cancer.

[45]  A. Olsen,et al.  Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene , 1995, Nature Genetics.

[46]  E. Thonar,et al.  Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee. , 1995, Arthritis and rheumatism.

[47]  J. Weidner,et al.  VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis. , 1995, The Journal of clinical investigation.

[48]  P. Dieppe,et al.  Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint. , 1995, British journal of rheumatology.

[49]  B. Månsson,et al.  Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. , 1995, The Journal of clinical investigation.

[50]  D. Heinegård,et al.  Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis. , 1995, Arthritis and rheumatism.

[51]  G. Newton,et al.  Characterization of human and mouse cartilage oligomeric matrix protein. , 1994, Genomics.

[52]  K. Hørslev-Petersen,et al.  Urinary hydroxypyridinium cross-links of collagen in rheumatoid arthritis. Relation to disease activity and effects of methylprednisolone. , 1994, British journal of rheumatology.

[53]  P. Dieppe,et al.  Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis. , 1994, The Journal of clinical investigation.

[54]  P. Schnegelsberg,et al.  Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[55]  C. Rorabeck,et al.  Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. , 1994, The Journal of clinical investigation.

[56]  D. Heinegård,et al.  Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis. , 1994, Annals of the rheumatic diseases.

[57]  Brian,et al.  Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. , 1993, The Journal of biological chemistry.

[58]  B. Johnstone,et al.  Immunohistochemical analysis of 3-B-(-) and 7-D-4 epitope expression in canine osteoarthritis. , 1993, Arthritis and rheumatism.

[59]  J. Johansen,et al.  A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid. , 1993, British journal of rheumatology.

[60]  A Bairoch,et al.  New families in the classification of glycosyl hydrolases based on amino acid sequence similarities. , 1993, The Biochemical journal.

[61]  L. Lohmander,et al.  Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. , 1993, Arthritis and rheumatism.

[62]  A. Poole,et al.  Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. , 1992, The Journal of clinical investigation.

[63]  D. Heinegård,et al.  COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. , 1992, The Journal of biological chemistry.

[64]  T. Spector,et al.  Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis. , 1992, British journal of rheumatology.

[65]  T. Saxne,et al.  Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis. , 1992, British journal of rheumatology.

[66]  D. Heinegård,et al.  Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. , 1992, British journal of rheumatology.

[67]  L. Lohmander,et al.  The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. , 1992, The Journal of clinical investigation.

[68]  D. Heinegård,et al.  Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. , 1992, Arthritis and rheumatism.

[69]  M. Goldring,et al.  Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide , 1991, The Journal of cell biology.

[70]  R. Timpl,et al.  localization of type VI collagen in the lining cell layer of normal and rheumatoid synovium. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[71]  T. Fields,et al.  Chick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment. , 1990, The Journal of biological chemistry.

[72]  V. Ribitsch.  Viscoelastic Behaviour of Synovial Fluids and Artificial Replacements , 1990 .

[73]  P. Robey.  The Biochemistry of Bone , 1989 .

[74]  R. Sturrock,et al.  Urinary excretion of the hydroxypyridinium cross links of collagen in patients with rheumatoid arthritis. , 1989, Annals of the rheumatic diseases.

[75]  D Heinegård,et al.  Structure and biology of cartilage and bone matrix noncollagenous macromolecules , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[76]  P. Roughley,et al.  Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency. , 1989, The Biochemical journal.

[77]  G. R. Dodge,et al.  Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1. , 1989, The Journal of clinical investigation.

[78]  L. Vaughan,et al.  Cartilage contains mixed fibrils of collagen types II, IX, and XI , 1989, The Journal of cell biology.

[79]  P. Mourão,et al.  Distribution of chondroitin 4-sulfate and chondroitin 6-sulfate in human articular and growth cartilage. , 1988, Arthritis and rheumatism.

[80]  E. Thonar,et al.  Serum keratan sulfate levels in osteoarthritis patients. , 1988, Arthritis and rheumatism.

[81]  W. Hurley,et al.  Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating period. , 1988, Biochemical and biophysical research communications.

[82]  E Ruoslahti,et al.  Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[83]  E. Thonar,et al.  Quantification of keratan sulfate in blood as a marker of cartilage catabolism. , 1985, The Journal of rheumatology.

[84]  P. Roughley,et al.  Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans. , 1986, The Biochemical journal.

[85]  D. Heinegård,et al.  DIFFERENCE IN CARTILAGE PROTEOGLYCAN LEVEL IN SYNOVIAL FLUID IN EARLY RHEUMATOID ARTHRITIS AND REACTIVE ARTHRITIS , 1985, The Lancet.

[86]  T. Koob,et al.  Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography. , 1984, Analytical biochemistry.

[87]  S. Robins.  Cross-linking of collagen. Isolation, structural characterization and glycosylation of pyridinoline. , 1983, The Biochemical journal.

[88]  B. Caterson,et al.  Identification of a monoclonal antibody that specifically recognizes corneal and skeletal keratan sulfate. Monoclonal antibodies to cartilage proteoglycan. , 1983, The Journal of biological chemistry.