Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses

[1]  Rajita Sinha,et al.  Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions , 2012, Biological Psychiatry.

[2]  F. Holsboer,et al.  Dendritic Morphology of Hippocampal and Amygdalar Neurons in Adolescent Mice Is Resilient to Genetic Differences in Stress Reactivity , 2012, PloS one.

[3]  Walter Heindel,et al.  Limbic Scars: Long-Term Consequences of Childhood Maltreatment Revealed by Functional and Structural Magnetic Resonance Imaging , 2012, Biological Psychiatry.

[4]  J. Coyle,et al.  The NMDA receptor co-agonists, d-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex , 2012, Neurobiology of Disease.

[5]  S. Kelly,et al.  Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens. , 2012, Neurotoxicology and teratology.

[6]  M. Qin,et al.  Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice , 2011, Neuroscience.

[7]  W. Gibson,et al.  A Model of NMDA Receptor Control of F-actin Treadmilling in Synaptic Spines and Their Growth , 2011, Bulletin of mathematical biology.

[8]  Mark Ellisman,et al.  Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons , 2011, Brain Research.

[9]  M. Bennett,et al.  The prefrontal–limbic network in depression: A core pathology of synapse regression , 2011, Progress in Neurobiology.

[10]  B. Mcewen,et al.  Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons , 2011, Hippocampus.

[11]  A. Mechelli,et al.  Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study , 2011, Stress.

[12]  B. McEwen,et al.  Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress. , 2011, Cerebral cortex.

[13]  G. Lynch,et al.  Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling , 2010, Proceedings of the National Academy of Sciences.

[14]  Osamu Abe,et al.  Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder , 2009, Psychiatry Research: Neuroimaging.

[15]  J. Frahm,et al.  In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice. , 2009, Cerebral Cortex.

[16]  Fred J. Helmstetter,et al.  Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study , 2009, Neuroreport.

[17]  Patrick R Hof,et al.  Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific. , 2009, Cerebral cortex.

[18]  S. Chattarji,et al.  Lithium treatment prevents stress-induced dendritic remodeling in the rodent amygdala , 2009, Neuroscience.

[19]  G. Tseng,et al.  Fatigue reversibly reduced cortical and hippocampal dendritic spines concurrent with compromise of motor endurance and spatial memory , 2009, Neuroscience.

[20]  T. Raju,et al.  Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats , 2009, Neuroscience Letters.

[21]  K. Braun,et al.  Juvenile separation stress induces rapid region- and layer-specific changes in S100ß- and glial fibrillary acidic protein–immunoreactivity in astrocytes of the rodent medial prefrontal cortex , 2009, Neuroscience.

[22]  Daniel Rueckert,et al.  Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI , 2009, Brain Research.

[23]  L. Garcia-Segura,et al.  Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells , 2009, International Journal of Developmental Neuroscience.

[24]  J. Ojemann,et al.  Uniquely Hominid Features of Adult Human Astrocytes , 2009, The Journal of Neuroscience.

[25]  Alex S. Ferecskó,et al.  The fractions of short- and long-range connections in the visual cortex , 2009, Proceedings of the National Academy of Sciences.

[26]  T. Raju,et al.  Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats , 2009, Journal of neuroscience research.

[27]  C. Cavaliere,et al.  Neonatal separation stress reduces glial fibrillary acidic protein‐ and S100β‐immunoreactive astrocytes in the rat medial precentral cortex , 2009, Developmental neurobiology.

[28]  A. J. Morton,et al.  Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease , 2009, Neurobiology of Disease.

[29]  T. Shors,et al.  Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females , 2009, Neuroscience Letters.

[30]  Emmanuel Chereul,et al.  Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD , 2008, Journal of neuroscience research.

[31]  B. Pakkenberg,et al.  Neocortical glial cell numbers in human brains , 2008, Neurobiology of Aging.

[32]  S. Petrosino,et al.  Gender‐dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: A possible role for the endocannabinoid system , 2008, Developmental neurobiology.

[33]  M. Onozuka,et al.  The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region , 2008, Neuroscience Letters.

[34]  C. Nicholson,et al.  Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change , 2008, The Journal of Neuroscience.

[35]  Gary H. Glover,et al.  Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain , 2008, NeuroImage.

[36]  P. Morgado,et al.  Dissociation of the morphological correlates of stress‐induced anxiety and fear , 2008, The European journal of neuroscience.

[37]  Douglas B. Ehlenberger,et al.  Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex , 2008, The Journal of comparative neurology.

[38]  JaneR . Taylor,et al.  Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat , 2007, Biological Psychiatry.

[39]  A. Dall’Oglio,et al.  Dendritic spines in the posterodorsal medial amygdala after restraint stress and ageing in rats , 2007, Neuroscience Letters.

[40]  C. Conrad,et al.  The effects of chronic stress on hippocampal morphology and function: An evaluation of chronic restraint paradigms , 2007, Brain Research.

[41]  E. Fuchs,et al.  Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress , 2007, Neural plasticity.

[42]  T. Leergaard,et al.  Branching of individual somatosensory cerebropontine axons in rat: evidence of divergence , 2007, Brain Structure and Function.

[43]  J. Feldon,et al.  Long-term effects of early life deprivation on brain glia in Fischer rats , 2007, Brain Research.

[44]  S. Chattarji,et al.  Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator , 2007, Neuroscience.

[45]  M. Stewart,et al.  Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: A stereological and three-dimensional ultrastructural study , 2006, Neuroscience.

[46]  Loretta S. Malta,et al.  A meta-analysis of structural brain abnormalities in PTSD , 2006, Neuroscience & Biobehavioral Reviews.

[47]  Milos Pekny,et al.  Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury , 2006, Proceedings of the National Academy of Sciences.

[48]  B. Anderson,et al.  Synapse loss from chronically elevated glucocorticoids: Relationship to neuropil volume and cell number in hippocampal area CA3 , 2006, The Journal of comparative neurology.

[49]  Bruce S. McEwen,et al.  Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting , 2006, The Journal of Neuroscience.

[50]  A. Alpár,et al.  Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice , 2006, Brain Research.

[51]  Yogesh K. Dwivedi,et al.  Hippocampal cell proliferation regulation by repeated stress and antidepressants , 2006, Neuroreport.

[52]  J. Morrison,et al.  Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. , 2006, Cerebral cortex.

[53]  Dewen Hu,et al.  Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: A voxel-based morphometric study , 2006, Psychiatry Research: Neuroimaging.

[54]  E. Rubel,et al.  The Level and Integrity of Synaptic Input Regulates Dendrite Structure , 2006, The Journal of Neuroscience.

[55]  P. Hof,et al.  A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy , 2005, Neuroscience.

[56]  S. Chattarji,et al.  Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[57]  J. Morrison,et al.  Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress , 2005, Experimental Neurology.

[58]  T. Mazel,et al.  Reduced extracellular space in the brain of tenascin‐R‐ and HNK‐1‐sulphotransferase deficient mice , 2005, The European journal of neuroscience.

[59]  D P Auer,et al.  Corticosteroid status influences the volume of the rat cingulate cortex - a magnetic resonance imaging study. , 2005, Journal of psychiatric research.

[60]  N. Sousa,et al.  Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors , 2005, The Journal of Neuroscience.

[61]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[62]  T. Mazel,et al.  Changes in extracellular space size and geometry in APP23 transgenic mice: a model of Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  J. Morrison,et al.  Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex , 2004, Neuroscience.

[64]  C. Conrad,et al.  Chronic stress enhances ibotenic acid-induced damage selectively within the hippocampal CA3 region of male, but not female rats , 2004, Neuroscience.

[65]  S. Chattarji,et al.  Recovery after chronic stress fails to reverse amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior , 2004, Neuroscience.

[66]  Susan C. Cook,et al.  Chronic stress alters dendritic morphology in rat medial prefrontal cortex. , 2004, Journal of neurobiology.

[67]  D. Chklovskii,et al.  Class-Specific Features of Neuronal Wiring , 2004, Neuron.

[68]  Mark H Ellisman,et al.  Tri-dimensional morphometric analysis of astrocytic processes with high voltage electron microscopy of thick Golgi preparations , 2004, Journal of neurocytology.

[69]  J. Price,et al.  Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes , 2004, Biological Psychiatry.

[70]  J. Špaček,et al.  Three-Dimensional analysis of dendritic spines , 1983, Anatomy and Embryology.

[71]  M. Frotscher,et al.  Synaptic reorganization in the rabbit hippocampus after lesion of commissural afferents , 2004, Anatomy and Embryology.

[72]  C. Knox,et al.  Brain aging in normotensive and hypertensive strains of rats , 2004, Acta Neuropathologica.

[73]  C. Knox,et al.  Brain aging in normotensive and hypertensive strains of rats , 2004, Acta Neuropathologica.

[74]  N. Alpert,et al.  See Blockindiscussions, Blockinstats, Blockinand Blockinauthor Blockinprofiles Blockinfor Blockinthis Blockinpublication Hippocampal Blockinfunction Blockinin Blockinposttraumatic Blockinstress Disorder Hippocampal Function in Posttraumatic Stress Disorder the Goal of the Current Research Was to Use , 2022 .

[75]  Richard J Smeyne,et al.  Regional differences in cortical dendrite morphology following in utero exposure to cocaine. , 2003, Brain research. Developmental brain research.

[76]  Rafael Yuste,et al.  Systematic regulation of spine sizes and densities in pyramidal neurons. , 2003, Journal of neurobiology.

[77]  D. McCloskey,et al.  Chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats , 2003, Neurobiology of Learning and Memory.

[78]  Patrick R Hof,et al.  Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia , 2003, Biological Psychiatry.

[79]  S. Chattarji,et al.  Effects of chronic stress on dendritic arborization in the central and extended amygdala , 2003, Brain Research.

[80]  T. Kosaka,et al.  Structural and quantitative analysis of astrocytes in the mouse hippocampus , 2002, Neuroscience.

[81]  M. D. de Leon,et al.  Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI. , 2002, Brain research. Brain research protocols.

[82]  S. Chattarji,et al.  Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons , 2002, The Journal of Neuroscience.

[83]  Jens Frahm,et al.  Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[84]  Bruce S. McEwen,et al.  The neurobiology of stress: from serendipity to clinical relevance. , 2000, Brain research.

[85]  N. Sousa,et al.  Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement , 2000, Neuroscience.

[86]  Joseph E LeDoux,et al.  Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. , 1999, Behavioral neuroscience.

[87]  D. Moore,et al.  Effects of unilateral cochlear removal on dendrites in the gerbil medial superior olivary nucleus , 1999, The European journal of neuroscience.

[88]  L. Garey.  Cortex: Statistics and Geometry of Neuronal Connectivity, 2nd edn. By V. BRAITENBERG and A. SCHÜZ. (Pp. xiii+249; 90 figures; ISBN 3 540 63816 4). Berlin: Springer. 1998. , 1999 .

[89]  F. Holsboer,et al.  Maintenance of hippocampal cell numbers in young and aged rats submitted to chronic unpredictable stress. Comparison with the effects of corticosterone treatment. , 1998, Stress.

[90]  Prof. Dr. Dr. Valentino Braitenberg,et al.  Cortex: Statistics and Geometry of Neuronal Connectivity , 1998, Springer Berlin Heidelberg.

[91]  J Wenzel,et al.  Functional Specialization and Topographic Segregation of Hippocampal Astrocytes , 1998, The Journal of Neuroscience.

[92]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[93]  N. Bannister,et al.  Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: II. Spine distributions , 1995, The Journal of comparative neurology.

[94]  P Andersen,et al.  Analysis of dendritic spines in rat CA1 pyramidal cells intracellularly filled with a fluorescent dye , 1995, The Journal of comparative neurology.

[95]  B. Pakkenberg,et al.  Do alcoholics drink their neurons away? , 1993, The Lancet.

[96]  A. Lehmenkühler,et al.  Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis , 1993, Neuroscience.

[97]  Bruce S. McEwen,et al.  Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons , 1992, Brain Research.

[98]  M. Krug,et al.  The influence of long-term potentiation on the spatial relationship between astrocyte processes and potentiated synapses in the dentate gyrus neuropil of rat brain , 1991, Brain Research.

[99]  J. Hámori.  Morphological plasticity of postsynaptic neurones in reactive synaptogenesis. , 1990, The Journal of experimental biology.

[100]  G. Palm,et al.  Density of neurons and synapses in the cerebral cortex of the mouse , 1989, The Journal of comparative neurology.

[101]  E. Rubel,et al.  Rapid changes in ultrastructure during deafferentation‐induced dendritic atrophy , 1989, The Journal of comparative neurology.

[102]  E. Rubel,et al.  Changes in neuronal cell bodies in N. laminaris during deafferentation‐induced dendritic atrophy , 1989, The Journal of comparative neurology.

[103]  J. Hámori,et al.  A quantitative study of morphological reorganization following chronic optic deafferentation in the adult cat dorsal lateral geniculate nucleus , 1987, The Journal of comparative neurology.

[104]  S. Hoff.  Lesion-induced transneuronal plasticity in the adult rat hippocampus , 1986, Neuroscience.

[105]  M. A. Bell,et al.  Laminar variation in the microvascular architecture of normal human visual cortex (area 17) , 1985, Brain Research.

[106]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[107]  H. Haug,et al.  Morphometry of cortical neurons. The best estimation of perikaryon volume from the projection area. , 1982, Microscopica acta.

[108]  C. Nicholson,et al.  Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. , 1981, The Journal of physiology.

[109]  T. Yamamoto,et al.  Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons , 1981, Brain Research Bulletin.

[110]  T. Yamamoto,et al.  Postnatal ontogenesis of hippocampal CA1 area in rats. II. Development of ultrastructure in stratum lacunosum and moleculare , 1981, Brain Research Bulletin.

[111]  M. A. Matthews,et al.  SPINAL CORD TRANSECTION: A QUANTITATIVE ANALYSIS OF ELEMENTS OF THE CONNECTIVE TISSUE MATRIX FORMED WITHIN THE SITE OF LESION FOLLOWING ADMINISTRATION OF PIROMEN, CYTOXAN OR TRYPSIN , 1979, Neuropathology and applied neurobiology.

[112]  J. Westman,et al.  Volume composition of the lateral cervical nucleus in the cat. I. A stereological and electron microscopical study of normal and deafferentated animals , 1977, Journal of neurocytology.

[113]  F. Benes,et al.  Rapid dendritic atrophy following deafferentation: An EM morphometric analysis , 1977, Brain Research.

[114]  Gary Lynch,et al.  An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration , 1976, Brain Research.

[115]  H. G. Minkwitz,et al.  [The ontogenetic development of pyramidal neurons in the hippocampus (CA1) of the rat]. , 1975, Journal fur Hirnforschung.

[116]  J. Wenzel,et al.  [Distribution of spines on the pyramidal neurons in the CA-1 region of the hippocampus in the rat]. , 1974, Zeitschrift fur mikroskopisch-anatomische Forschung.

[117]  H. Haug,et al.  [Determination of quantitative parameters of the fine structure in the visual cortex of the cat, also a methodological contribution on measuring the neuropil (author's transl)]. , 1973, Microscopica acta.

[118]  D. Lindsley,et al.  The human brain in figures and tables : a quantitative handbook , 1968 .

[119]  B. Cragg.  The density of synapses and neurones in the motor and visual areas of the cerebral cortex. , 1967, Journal of anatomy.

[120]  M. Abercrombie.  Estimation of nuclear population from microtome sections , 1946, The Anatomical record.