Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology
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E. Wanker | F. Cicchetti | R. Truant | Frank Herrmann | S. Lévesque | C. Bazenet | Melanie Alpaugh | M. Saint‐Pierre | S. Lacroix | P. Gould | Abid Oueslati | A. P. Garneau | P. Isenring | Anne Ast | Maria Masnata | Marie Rieux | G. Sciacca | H. L. Denis | Giacomo Sciacca | M. Alpaugh
[1] J. Kordower,et al. Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms , 2019, Acta Neuropathologica.
[2] L. Tian,et al. Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial , 2019, JAMA neurology.
[3] R. Barker,et al. Platelet abnormalities in Huntington’s disease , 2018, Journal of Neurology, Neurosurgery, and Psychiatry.
[4] Y. Hsu,et al. Insights into GABAAergic system alteration in Huntington's disease , 2018, Royal Society Open Biology.
[5] E. Wanker,et al. mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. , 2018, Molecular cell.
[6] X. Yao,et al. Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies , 2018, Molecular Psychiatry.
[7] Jung Hyun Yoo,et al. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin , 2018, Human molecular genetics.
[8] B. Tang. Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin , 2018, Cells.
[9] S. Plassmann,et al. Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching , 2017, bioRxiv.
[10] Seung-Jae Lee,et al. Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans , 2017, Experimental neurobiology.
[11] F. Cicchetti,et al. The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications , 2017, Front. Neurosci..
[12] L. Pereira de Almeida,et al. Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases. , 2017, Journal of controlled release : official journal of the Controlled Release Society.
[13] S. Villeda,et al. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease , 2017, F1000Research.
[14] D. Rubinsztein,et al. Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies. , 2017, Cold Spring Harbor perspectives in medicine.
[15] N. Price,et al. Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease , 2017, PloS one.
[16] S. Tabrizi,et al. Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells , 2017, Scientific Reports.
[17] M. D'Esposito,et al. Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease , 2017, Scientific Reports.
[18] P. Nigrovic,et al. Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses , 2016, Scientific Reports.
[19] Yujin E. Kim,et al. Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors. , 2016, Molecular cell.
[20] A. Teixeira,et al. Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human Studies , 2016, Mediators of inflammation.
[21] H. Ullum,et al. Transmission of Neurodegenerative Disorders Through Blood Transfusion , 2016, Annals of Internal Medicine.
[22] Jihwan Song,et al. Human-to-mouse prion-like propagation of mutant huntingtin protein , 2016, Acta Neuropathologica.
[23] J. Couet,et al. Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria , 2016, PloS one.
[24] R. Nitsch,et al. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy , 2016, Acta Neuropathologica.
[25] S. Humbert,et al. The Biology of Huntingtin , 2016, Neuron.
[26] E. Giltay,et al. Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease. , 2016, Journal of Huntington's disease.
[27] B. Ganetzky,et al. Transcellular spreading of huntingtin aggregates in the Drosophila brain , 2015, Proceedings of the National Academy of Sciences.
[28] Susan T Francis,et al. Cerebrovascular and blood–brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology , 2015, Annals of neurology.
[29] S. Tabrizi,et al. Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. , 2015, The Journal of clinical investigation.
[30] Eric H Kim,et al. The Neuropathology of Huntington's Disease. , 2015, Current topics in behavioral neurosciences.
[31] A. Reiner,et al. Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease , 2014, Front. Syst. Neurosci..
[32] Diego Mantovani,et al. Mutant huntingtin is present in neuronal grafts in huntington disease patients , 2014, Annals of neurology.
[33] Danielle A. Simmons,et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice , 2014, Nature Medicine.
[34] A. Reiner,et al. Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice , 2013, Neurobiology of Disease.
[35] G. Lederkremer,et al. Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress , 2013, Nature Communications.
[36] I. Weissman,et al. Parabiosis in mice: a detailed protocol. , 2013, Journal of visualized experiments : JoVE.
[37] Mathias Jucker,et al. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases , 2013, Nature.
[38] R. Gold,et al. Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease , 2013, Neurology.
[39] Mei Kwan,et al. Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175 , 2012, PloS one.
[40] M. Diamond,et al. Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission? , 2012, Annals of neurology.
[41] S. Tabrizi,et al. Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. , 2012, The Journal of clinical investigation.
[42] Chris C. Tang,et al. Monitoring Huntington's disease progression through preclinical and early stages. , 2012, Neurodegenerative disease management.
[43] C. Soto. Transmissible Proteins: Expanding the Prion Heresy , 2012, Cell.
[44] E. Masliah,et al. Bone Marrow Transplantation Confers Modest Benefits in Mouse Models of Huntington's Disease , 2012, The Journal of Neuroscience.
[45] P. Snyder,et al. Biological markers of cognition in prodromal Huntington’s disease: A review , 2011, Brain and Cognition.
[46] P. Hemachandra Reddy,et al. Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. , 2011, Human molecular genetics.
[47] A. Reiner,et al. Genetics and neuropathology of Huntington's disease. , 2011, International review of neurobiology.
[48] E. Ramos,et al. Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
[49] Arrate Muñoz-Barrutia,et al. 3D reconstruction of histological sections: Application to mammary gland tissue , 2010, Microscopy research and technique.
[50] Jeffrey H Kordower,et al. Differential vulnerability of neurons in Huntington’s disease: the role of cell type‐specific features , 2010, Journal of neurochemistry.
[51] M. MacDonald,et al. Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models , 2009, Neurobiology of Disease.
[52] J. Caviston,et al. Huntingtin as an essential integrator of intracellular vesicular trafficking. , 2009, Trends in cell biology.
[53] V. Beneš,et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. , 2009, Clinical chemistry.
[54] R. Barker,et al. The current clinical management of Huntington's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.
[55] M. Hayden,et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease , 2008, The Journal of experimental medicine.
[56] J. Vonsattel,et al. Neuropathology of Huntington's disease. , 2008, Handbook of clinical neurology.
[57] L. Herzenberg,et al. Modern flow cytometry: a practical approach. , 2007, Clinics in laboratory medicine.
[58] Stephen Naylor,et al. Mapping the human plasma proteome by SCX-LC-IMS-MS , 2007, Journal of the American Society for Mass Spectrometry.
[59] D. Bennett,et al. Biochemical Characterization of Aβ and Tau Pathologies in Mild Cognitive Impairment and Alzheimer's Disease , 2007 .
[60] D. Bennett,et al. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. , 2007, Journal of Alzheimer's disease : JAD.
[61] A. Danek,et al. Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels , 2004, BMC Neuroscience.
[62] M. MacDonald,et al. Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. , 2004, Human molecular genetics.
[63] Ronald Wetzel,et al. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. , 2004, Molecular cell.
[64] E. Simpson,et al. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. , 2003, Human molecular genetics.
[65] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[66] E A Zemskov,et al. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. , 2001, Human molecular genetics.
[67] C. Blakemore,et al. N‐Acetylaspartate and DARPP‐32 levels decrease in the corpus striatum of Huntington's disease mice , 2000, Neuroreport.
[68] Claire-Anne Gutekunst,et al. Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology , 1999, The Journal of Neuroscience.
[69] J. DeFelipe. Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex , 1997, Journal of Chemical Neuroanatomy.
[70] Mark Turmaine,et al. Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation , 1997, Cell.
[71] A. Parent,et al. Sparing of striatal neurons coexpressing calretinin and substance P (NK1) receptor in Huntington's disease , 1996, Brain Research.
[72] A. Parent,et al. Calretinin-immunoreactive neurons in the human striatum , 1995, Brain Research.
[73] W. Zidek,et al. Transmission of hypertension in rats by cross circulation. , 1989, Hypertension.
[74] R. Ferrante,et al. Neuropathological Classification of Huntington's Disease , 1985, Journal of neuropathology and experimental neurology.