The application transparency of secondary equipment in Smart Substation is low, the logical linkage is poor, and the intercommunication ability of equipment from different manufacturers is limited, which seriously restricts the promotion and application of advanced application functions. In view of the above problems, this paper carries out the research on advanced application configuration design technology of Smart substation, realizes automatic generation of advanced application logic through configuration configuration technology, realizes real-time display of logic status through configuration monitoring technology, and develops a measurement and control device supporting configuration design. The research results of this project are applied to a 110kV Smart substation in Hubei Province. The application results show that the technology described in this paper can effectively improve the application quality and efficiency of advanced application functions.