[NM-242] Avoiding Anaphylaxis: Pediatric Cutaneous Mastocytosis and Anesthetic Challenges

Background: Pediatric mastocytosis includes a rare spectrum of diseases characterized by abnormal mast cell infiltration in one or more organs. The cutaneous form (urticaria pigmentosa) is the most frequent pediatric clinical variant.1 Various stimuli may cause mast cell degranulation leading to mediator release. However, there have only been few reports of serious anesthesia-related complications in pediatric populations.2 Dexmedetomidine is a potential mast cell stabilizer that has been shown to block histamine-induced bronchoconstriction.3