Abstract Aiming at the shortcomings of single-discipline fatigue design and life prediction optimization design method for high-speed trains, considering the characteristics of structural design integrity, a durability analysis method for key structural components based on multi-disciplinary fatigue optimization design is proposed. According to the characteristics of vibration fatigue and structural failure of key structural components of high-speed trains, the multi-disciplinary fatigue design of carbody components is carried out from the perspectives of materials, loads and structural design. In the research process, qualitative and quantitative analysis and comparison of multi-objective optimization analysis (MOO) and multi-disciplinary optimization (MDO) processes were carried out. At the same time, considering the actual example, considering the vibration characteristics of the vehicle structure, the typical load spectrum and the complex material characteristics, the failure characteristics of the structural components are analyzed in detail. The research results are shown that there are certain limitations in single-disciplinary fatigue design and analysis. In order to effectively solve the complex engineering structure failure problem, it is necessary to fully consider the vibration characteristics of the entire vehicle structure. Through the multi-disciplinary fatigue design and optimization method of high-speed train structural components, the safety and structural integrity of key structural components of rail transit can be better guaranteed.
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