Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review

BackgroundChronic wounds impose a significant and often underappreciated burden to the individual, the healthcare system and the society as a whole. Preliminary literature search suggests that there are at present no reliable estimates on the total prevalence of chronic wounds for different settings and categories of chronic wounds. Such information is essential for policy and planning purposes as the increasing number of elderly and the prevalence of lifestyle diseases point in the direction of an increased burden. Knowledge about the prevalence and incidence of chronic wounds in relation to population characteristics is important for informing healthcare planning and resource allocation. The objective is to present a transparent process for how to review the existing literature on the prevalence and incidence rates of chronic wounds and resulting implications.Methods/designWe will search electronic bibliographic databases (MEDLINE, EMBASE, the EBM Reviews and Cochrane, Cumulative Index to Nursing and allied Health Literature (CINAHL), PsycINFO, Global Health) and reference lists of included articles. Two investigators will independently screen titles and abstracts and select studies involving adults with chronic wounds. These investigators will also independently extract data using a pre-designed data extraction form that will cover information on demographics, diagnostics including disease prevalence, medical history, hospital and community-based management and outcomes. Subgroup analysis and sensitivity analysis will be performed to address the heterogeneity across studies. Meta-analysis will also be performed if homogeneous group of studies will be found. The collective evidence will be further stratified according to the important background variables if allowed.DiscussionThis study will describe the available epidemiological evidence and summarise prevalence and incidence rates of chronic wounds and related complications. A better understanding of the relationship between population profile and the prevalence of chronic wounds and related complications will be helpful in the development of guidelines for patient management.Systematic review registrationPROSPERO CRD42016037355

[1]  E. S. Pearson,et al.  THE USE OF CONFIDENCE OR FIDUCIAL LIMITS ILLUSTRATED IN THE CASE OF THE BINOMIAL , 1934 .

[2]  M. Augustin,et al.  Effectiveness of Advanced versus Conventional Wound Dressings on Healing of Chronic Wounds: Systematic Review and Meta-Analysis , 2013, Dermatology.

[3]  D. Zygun,et al.  Incidence, prevalence, and occurrence rate of infection among adults hospitalized after traumatic brain injury: study protocol for a systematic review and meta-analysis , 2013, Systematic Reviews.

[4]  L. Kloth.  The Roles of Physical Therapists in Wound Management, Part II: Patient and Wound Evaluation. , 2009, The journal of the American College of Certified Wound Specialists.

[5]  A. C. van der Wal,et al.  Causes, investigation and treatment of leg ulceration , 2003, The British journal of dermatology.

[6]  C. Wicke,et al.  Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[7]  J. Macdonald.  Global initiative for wound and lymphoedema care (GIWLC) , 2009 .

[8]  R. Kirsner.  The wound healing society chronic wound ulcer healing guidelines update of the 2006 guidelines—blending old with new , 2016, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[9]  Josip Car,et al.  Epidemiology of Alzheimer ' s disease and other forms of dementia in China , 1990-2010 , 2013 .

[10]  Z. Munn,et al.  The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. , 2014, International journal of health policy and management.

[11]  Hans-Oliver Rennekampff,et al.  Evidence-based Management Strategies for Treatment of Chronic Wounds , 2009, Eplasty.

[12]  Finn Gottrup,et al.  A specialized wound-healing center concept: importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds. , 2004, American journal of surgery.

[13]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[14]  P. Franks,et al.  The burden of chronic wounds in the UK. , 2008, Nursing times.

[15]  D. M. Cooper,et al.  Definitions and guidelines for assessment of wounds and evaluation of healing , 1994, Archives of dermatology.

[16]  B. Kuehn.  Chronic wound care guidelines issued. , 2007, JAMA.

[17]  K. Denny,et al.  Compromised wounds in Canada. , 2014, Healthcare quarterly.

[18]  Gordon H Guyatt,et al.  GRADE guidelines: 5. Rating the quality of evidence--publication bias. , 2011, Journal of clinical epidemiology.

[19]  P. Shekelle,et al.  Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement , 2015, Systematic Reviews.

[20]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[21]  D. Pritchard,et al.  Multiple actions of Lucilia sericata larvae in hard‐to‐heal wounds , 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

[22]  J. Higgins,et al.  Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration , 2013 .

[23]  T. K. Hunt,et al.  Human skin wounds: A major and snowballing threat to public health and the economy , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[24]  D. Margolis.  Epidemiology of Wounds , 2012 .

[25]  N. Graves,et al.  The prevalence and incidence of chronic wounds: A literature review , 2014 .