Method of azimuthally stable Mueller-matrix diagnostics of blood plasma polycrystalline films in cancer diagnostics

A new information optical technique of diagnostics of the structure of polycrystalline films of blood plasma is proposed. The model of Mueller-matrix description of mechanisms of optical anisotropy of such objects as optical activity, birefringence, as well as linear and circular dichroism is suggested. The ensemble of informationally topical azimuthally stable Mueller-matrix invariants is determined. Within the statistical analysis of such parameters distributions the objective criteria of differentiation of films of blood plasma taken from healthy and patients with liver cirrhosis were determined. From the point of view of probative medicine the operational characteristics (sensitivity, specificity and accuracy) of the information-optical method of Mueller-matrix mapping of polycrystalline films of blood plasma were found and its efficiency in diagnostics of liver cirrhosis was demonstrated. Prospects of application of the method in experimental medicine to differentiate postmortem changes of the myocardial tissue was examined.

[1]  Oleg V. Angelsky,et al.  Appearance of wavefront dislocations under interference among beams with simple wavefronts , 1997, Correlation Optics.

[2]  Yu. A. Ushenko,et al.  Polarization-based visualization of multifractal structures for the diagnostics of pathological changes in biological tissues , 2000 .

[3]  Matthew H. Smith,et al.  Interpreting Mueller matrix images of tissues , 2001, SPIE BiOS.

[4]  A G Ushenko,et al.  Wavelet analysis of two-dimensional birefringence images of architectonics in biotissues for diagnosing pathological changes. , 2004, Journal of biomedical optics.

[5]  O V Angelsky,et al.  Polarization visualization and selection of biotissue image two-layer scattering medium. , 2005, Journal of biomedical optics.

[6]  Oleg Angelsky,et al.  On the feasibility for determining the amplitude zeroes in polychromatic fields. , 2005, Optics express.

[7]  E. A. Oberemok,et al.  Generalized matrix equivalence theorem for polarization theory. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[8]  Yu. A. Ushenko,et al.  A New Method of Mueller-Matrix Diagnostics and Differentiation of Early Oncological Changes of the Skin Derma , 2010 .

[9]  Oleg V. Angelsky,et al.  Statistical, Correlation, and Topological Approaches in Diagnostics of the Structure and Physiological State of Birefringent Biological Tissues , 2010 .

[10]  Oleg V. Angelsky,et al.  The Interconnection between the Coordinate Distribution of Mueller-Matrixes Images Characteristic Values of Biological Liquid Crystals Net and the Pathological Changes of Human Tissues , 2010 .

[11]  A. V. Dubolazov,et al.  Wavelet analysis for polarization inhomogeneous laser images of blood plasma , 2011, Other Conferences.

[12]  A. V. Karachevtsev,et al.  Wavelet-analysis for Laser Images of Blood Plasma , 2011 .

[13]  A. V. Dubolazov,et al.  Diagnostics of optical anisotropy changesin biological tissues using Müller matrix , 2011 .

[14]  Y. Ushenko,et al.  Mueller-matrix diagnostics of optical properties inherent to polycrystalline networks of human blood plasma , 2011 .

[15]  Yu. A. Ushenko,et al.  NEW PARAMETER FOR DESCRIBING AND ANALYZING THE OPTICAL-ANISOTROPIC PROPERTIES OF BIOLOGICAL TISSUES , 2011 .

[16]  Yu. A. Ushenko.  THE FEASIBILITIES OF USING THE STATISTICAL, FRACTAL AND SINGULAR PROCESSING OF HOMINAL BLOOD PLASMA PHASE IMAGES DURING THE DIAGNOSTICS AND DIFFERENTIATION OF MAMMARY GLAND PATHOLOGICAL STATES , 2012 .

[17]  O V Angelsky,et al.  Orbital rotation without orbital angular momentum: mechanical action of the spin part of the internal energy flow in light beams. , 2011, Optics express.

[18]  O. V. Angelsky,et al.  Scattering of inhomogeneous circularly polarized optical field and mechanical manifestation of the internal energy flows , 2012 .

[19]  T. M. Boychuk,et al.  Diagnostics of Structure and Physiological State of Birefringent Biological Tissues: Statistical, Correlation and Topological Approaches , 2013 .

[20]  O V Angelsky,et al.  Self-diffraction of continuous laser radiation in a disperse medium with absorbing particles. , 2013, Optics express.

[21]  Yu. A. Ushenko,et al.  CLASSIFYING OPTICAL PROPERTIES OF SURFACE- AND BULK-SCATTERING BIOLOGICAL LAYERS WITH POLARIZATION SINGULAR STATES , 2013 .