Ceramides Dissociate Steatosis and Insulin Resistance in the Human Liver in Non-Alcoholic Fatty Liver Disease Short title : Ceramides in Human Non-Alcoholic Fatty Liver Disease

[1]  A. Burt,et al.  Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. , 2015, Journal of hepatology.

[2]  R. Kolesnick,et al.  C16:0-ceramide signals insulin resistance. , 2014, Cell metabolism.

[3]  H. Yki-Järvinen Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. , 2014, The lancet. Diabetes & endocrinology.

[4]  S. Summers,et al.  CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. , 2014, Cell metabolism.

[5]  Matthias Blüher,et al.  Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. , 2014, Cell metabolism.

[6]  E. Schleicher,et al.  PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans , 2014, Diabetologia.

[7]  K. Petersen,et al.  The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes , 2014, Nature.

[8]  PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells , 2014, Human molecular genetics.

[9]  J. Browning,et al.  Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. , 2014, Gastroenterology.

[10]  H. Cheon,et al.  Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12 , 2014, Journal of Biomedical Science.

[11]  M. Steurer,et al.  Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[12]  Q. Anstee,et al.  The genetics of NAFLD , 2013, Nature Reviews Gastroenterology &Hepatology.

[13]  M. Roden,et al.  Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease , 2013, Molecular and Cellular Endocrinology.

[14]  Eliseo Guallar,et al.  Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. , 2013, American journal of epidemiology.

[15]  N. Lundbom,et al.  Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3 , 2013, Diabetologia.

[16]  S. Klein,et al.  Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. , 2012, Gastroenterology.

[17]  Sarah A. Scott,et al.  Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. , 2012, Cell metabolism.

[18]  S. Summers,et al.  A ceramide-centric view of insulin resistance. , 2012, Cell metabolism.

[19]  J. Hardies,et al.  Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease , 2012, Hepatology.

[20]  A. Khera,et al.  Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the Dallas Heart Study. , 2012, The Journal of clinical endocrinology and metabolism.

[21]  Xianlin Han,et al.  Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease , 2011, Proceedings of the National Academy of Sciences.

[22]  Jonathan C. Cohen,et al.  Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease* , 2011, The Journal of Biological Chemistry.

[23]  S. Sookoian,et al.  Meta‐analysis of the influence of I148M variant of patatin‐like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease , 2011, Hepatology.

[24]  Sandra Castillo,et al.  Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. , 2011, Analytical chemistry.

[25]  Sandra Castillo,et al.  Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. , 2011, Methods in molecular biology.

[26]  M. Orešič,et al.  Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. , 2010, Gastroenterology.

[27]  T. Liang,et al.  The association of genetic variability in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease , 2010, Hepatology.

[28]  M. Matsuda,et al.  Reduced Time Points to Calculate the Composite Index , 2010, Diabetes Care.

[29]  M. Orešič,et al.  Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra‐abdominal Adipose Tissue, and Serum , 2010, Obesity.

[30]  K. Clément,et al.  Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. , 2009, Journal of hepatology.

[31]  M. Ridderstråle,et al.  A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans , 2009, Diabetologia.

[32]  Takao Shimizu,et al.  Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. , 2009, Annual review of pharmacology and toxicology.

[33]  M. Orešič,et al.  Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver , 2009, Diabetes.

[34]  Alexander Pertsemlidis,et al.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease , 2008, Nature Genetics.

[35]  A. Kotronen,et al.  Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. , 2008, Gastroenterology.

[36]  R. McCuskey,et al.  Hepatic Microcirculation in Fatty Liver Disease , 2008, Anatomical record.

[37]  B. S. Mohammed,et al.  Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. , 2008, Gastroenterology.

[38]  B. S. Mohammed,et al.  Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. , 2008, Gastroenterology.

[39]  Michelle M Wiest,et al.  A lipidomic analysis of nonalcoholic fatty liver disease , 2007, Hepatology.

[40]  A. Häkkinen,et al.  Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity , 2007, Diabetes.

[41]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[42]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[43]  A. Häkkinen,et al.  Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. , 2002, The Journal of clinical endocrinology and metabolism.

[44]  A. Häkkinen,et al.  Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. , 2000, Diabetes.

[45]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.

[46]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[47]  R. Wolfe,et al.  Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. , 1998, Journal of lipid research.