The role of monovalent cations in the interaction between the cytotoxic T lymphocyte and its target

Evidence is provided for the participation of monovalent cations in both the binding and lytic phases of the lytic cycle. There appears to be one sodium requirement in the cytotoxic T lymphocyte‐target binding event (effective dose50 ∼ 35 mM) and possibly another sodium requirement in the delivery of the lethal hit (ED50 <7 mM). Potassium can replace sodium in the binding event but antagonizes the lethal hit phase (inhibitory dose50 ∼ 110 mM). Lithium antagonizes the binding event (ID50 ∼ 15 mM).

[1]  J. Russell,et al.  Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact. , 1980, Journal of immunology.

[2]  G. Weissmann,et al.  Stimulus-response coupling in the human neutrophil. Transmembrane potential and the role of extracellular Na+. , 1980, Biochimica et biophysica acta.

[3]  T. Kanno,et al.  Influence of external potassium concentration on secretory responses to cholecystokinin‐pancreozymin and ionophore A23187 in the pancreatic acinar cell. , 1978, The Journal of physiology.

[4]  P. Golstein,et al.  The lethal hit stage of mouse T and non‐T cell‐mediated cytolysis: differences in cation requirements and characterization of an analytical “cation pulse” method , 1976, European journal of immunology.

[5]  Michael Feldman,et al.  The frequency of effector cells in populations containing cytotoxic T lymphocytes , 1975 .

[6]  T. Strom,et al.  A comparison of the effects of metabolic inhibitors upon direct and antibody-dependent lymphocyte mediated cytotoxicity. , 1975, Cellular immunology.

[7]  E. Martz.  Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization. , 1975, Journal of immunology.

[8]  C. Henney.  Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events. , 1973, Journal of immunology.

[9]  M. R. Nicholls,et al.  Role of liver-cell potassium ions in secretion of serum albumin and lipoproteins. , 1970, The Biochemical journal.

[10]  P. Henderson,et al.  The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability. , 1969, The Biochemical journal.