AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor.
暂无分享,去创建一个
R. Adan | J. Oosterom | W. Nijenhuis | R A Adan | J Oosterom | W A Nijenhuis | Wouter A. J. Nijenhuis | R. Adan
[1] G. Barsh,et al. The role of agouti-related protein in regulating body weight. , 1999, Molecular medicine today.
[2] C. Mobbs,et al. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. , 1999, Endocrinology.
[3] A. Eberle,et al. B16‐G4F mouse melanoma cells: An MSH receptor‐deficient cell clone , 1993, FEBS letters.
[4] M. Tota,et al. ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. , 1997, Biochemical and biophysical research communications.
[5] R. Lefkowitz,et al. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.
[6] J. Burbach,et al. Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors* , 1999, The Journal of Biological Chemistry.
[7] C. Priest,et al. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. , 1998, Diabetes.
[8] J. Shutter,et al. Overexpression of Agrt leads to obesity in transgenic mice , 1997, Nature Genetics.
[9] G. Barsh,et al. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin. , 1997, The Journal of investigative dermatology.
[10] G. Barsh,et al. Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain , 1999, The Journal of Neuroscience.
[11] Victor J. Hruby,et al. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome , 1997, Nature.
[12] Y. Salomon. Adenylate cyclase assay. , 1979, Advances in cyclic nucleotide research.
[13] S. Watson,et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. , 1993, The Journal of biological chemistry.
[14] A. Thody,et al. Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis. , 1995, The Journal of endocrinology.
[15] R. Cone,et al. Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.
[16] S. Woods,et al. Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus , 1997, Diabetes.
[17] R. Cone,et al. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. , 1995, Journal of medicinal chemistry.
[18] G. Barsh,et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. , 1997, Science.
[19] W. Wilkison,et al. Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors. , 1996, Biochemical and biophysical research communications.
[20] W. Sadee,et al. A synthetic human Agouti‐related protein‐(83–132)‐NH2 fragment is a potent inhibitor of melanocortin receptor function , 1998, FEBS letters.
[21] G. Barsh,et al. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. , 1998, Genes & development.
[22] G. Milligan,et al. Inverse agonism: pharmacological curiosity or potential therapeutic strategy? , 1995, Trends in pharmacological sciences.
[23] G. Barsh,et al. The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals. , 1996, Pigment cell research.
[24] Richard P. Woychik,et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor , 1994, Nature.
[25] K. Clément,et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity , 1998, Nature Genetics.
[26] R. Palmiter,et al. Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides , 1999, Nature Genetics.
[27] S. Watson,et al. Molecular cloning of a novel melanocortin receptor. , 1993, The Journal of biological chemistry.
[28] W. Wilkison,et al. Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti. , 1997, Journal of receptor and signal transduction research.
[29] 健 海老原. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action , 2000 .
[30] R. Leurs,et al. Modulation of forskolin‐mediated adenylyl cyclase activation by constitutively active Gs‐coupled receptors , 1997, FEBS letters.
[31] G. Barsh,et al. Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. , 1999, Endocrinology.
[32] G. Barsh,et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. , 1993, Genes & development.
[33] Helen L. Yin,et al. The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells* , 1997, The Journal of Biological Chemistry.
[34] V. Katta,et al. Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein. , 1998, Biochemistry.
[35] Michael W. Schwartz,et al. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons , 1998, Nature Neuroscience.
[36] G. Barsh,et al. Characterization of Agouti-related protein binding to melanocortin receptors. , 1999, Molecular endocrinology.
[37] J. Shutter,et al. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. , 1997, Genes & development.
[38] K. Wakamatsu,et al. Agouti protein inhibits the production of eumelanin and phaeomelanin in the presence and absence of alpha-melanocyte stimulating hormone. , 1997, Pigment cell research.
[39] C. Priest,et al. Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin , 1998, Diabetes.
[40] Y. Konda,et al. Molecular cloning, expression, and characterization of a fifth melanocortin receptor. , 1994, Biochemical and biophysical research communications.
[41] G. Barsh,et al. Modulation of murine melanocyte function in vitro by agouti signal protein , 1997, The EMBO journal.
[42] J. Hebebrand,et al. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. , 1999, American journal of human genetics.
[43] R. Woychik,et al. Molecular characterization of the mouse agouti locus , 1992, Cell.
[44] S. O’Rahilly,et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity , 1998, Nature Genetics.
[45] S. Bloom,et al. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. , 1998, Endocrinology.
[46] P. Prusis,et al. Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist , 1999, British journal of pharmacology.