Venous thromboembolism according to age: the impact of an aging population.

BACKGROUND With the aging of the US population, there is concern that the rate of venous thromboembolism will increase, thereby increasing the health burden. In this study we sought to determine trends in the diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) in the elderly as well as the use of diagnostic tests. METHODS Data from the National Hospital Discharge Survey were used. These data are abstracted each year from a sample of records of patients discharged from non-federal short-stay hospitals in the entire United States. Main outcome measures were trends in rates of diagnosis of DVT and PE as well as trends in the use of diagnostic tests between 1979 and 1999. RESULTS The rates of diagnosis of DVT and PE and of the use of diagnostic tests over 21 years were markedly higher in elderly than in younger patients (P<.001). Although the rate of diagnosed DVT in elderly patients strikingly increased over the past decade (P< .001), that of PE has been relatively constant. There was a proportionately greater use of venous ultrasonography, ventilation-perfusion lung scanning, and pulmonary angiography in elderly than in younger patients. CONCLUSIONS Extensive use of diagnostic tests in elderly patients in the past decade has resulted in an increased diagnostic rate for DVT but not PE. The reason for this disparity is uncertain but may reflect early diagnosis and treatment of DVT. With the aging of the population, DVT will increase the health burden.

[1]  W. Ghali,et al.  Tracking the uptake of evidence: two decades of hospital practice trends for diagnosing deep vein thrombosis and pulmonary embolism. , 2003, Archives of internal medicine.

[2]  P. Stein,et al.  Deep venous thrombosis in a general hospital. , 2002, Chest.

[3]  P. Stein,et al.  Estimated incidence of acute pulmonary embolism in a community/teaching general hospital. , 2002, Chest.

[4]  J. Popovic 1999 National Hospital Discharge Survey: annual summary with detailed diagnosis and procedure data. , 2001, Vital and health statistics. Series 13, Data from the National Health Survey.

[5]  J. Heit,et al.  Prevention of venous thromboembolism. , 2001, Clinics in geriatric medicine.

[6]  R. Pokras,et al.  Design and operation of the National Hospital Discharge Survey: 1988 redesign. , 2000, Vital and health statistics. Ser. 1, Programs and collection procedures.

[7]  L. Kozak,et al.  National hospital discharge survey: annual summary, 1998. , 2000, Vital and health statistics. Series 13, Data from the National Health Survey.

[8]  M. Owings,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1997. , 1999, Vital and health statistics. Series 13, Data from the National Health Survey.

[9]  P. Stein,et al.  Incidence of Acute Pulmonary Embolism in a General Hospital: Relation to Age, Sex, and Race , 1999 .

[10]  B A Carroll,et al.  The diagnostic approach to acute venous thromboembolism. Clinical practice guideline. American Thoracic Society. , 1999, American journal of respiratory and critical care medicine.

[11]  Samuel Z Goldhaber,et al.  Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) , 1999, The Lancet.

[12]  W M O'Fallon,et al.  Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. , 1998, Archives of internal medicine.

[13]  L. Kozak,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1996. , 1998, Vital and health statistics. Series 13, Data from the National Health Survey.

[14]  L. Welin,et al.  DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM IN THE GENERAL POPULATION. THE STUDY OF MEN BORN IN 1913 , 1997 .

[15]  P. Morand,et al.  Clinical epidemiology of venous thromboembolic disease. Results of a French Multicentre Registry. , 1997, European heart journal.

[16]  B. Gillum,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1994. , 1997, Vital and health statistics. Series 13, Data from the National Health Survey.

[17]  B. Gillum,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1995. , 1997, Vital and health statistics. Series 13, Data from the National Health Survey.

[18]  X Marchandise,et al.  Diagnosis of pulmonary embolism with spiral CT: comparison with pulmonary angiography and scintigraphy. , 1996, Radiology.

[19]  Ac Hurt,et al.  St. Anthony's ICD-9-CM Code Book , 1996 .

[20]  C. Giuntini,et al.  Pulmonary embolism: epidemiology. , 1995, Chest.

[21]  J. Heit,et al.  Prevention of venous thromboembolism. , 1995, Chest.

[22]  E J Graves,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1993. , 1995, Vital and health statistics. Series 13, Data from the National Health Survey.

[23]  J. Birkmeyer,et al.  The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. , 1994, Archives of internal medicine.

[24]  E. Graves Detailed diagnoses and procedures, National Hospital Discharge Survey, 1991. , 1994, Vital and health statistics. Series 13, Data from the National Health Survey.

[25]  D. Mark,et al.  Bias in the coding of hospital discharge data and its implications for quality assessment. , 1994, Medical care.

[26]  P. Sheedy,et al.  Pulmonary embolism: diagnosis with electron-beam CT. , 1993, Radiology.

[27]  E. Graves National hospital discharge survey: annual summary, 1991. , 1993, Vital and health statistics. Series 13, Data from the National Health Survey.

[28]  B. Lindblad,et al.  A prospective study of the incidence of deep‐vein thrombosis within a defined urban population , 1992, Journal of internal medicine.

[29]  E. Graves Detailed diagnoses and procedures, national hospital discharge survey, 1990. , 1992, Vital and health statistics. Series 13, Data from the National Health Survey.

[30]  D. Hosmer,et al.  A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. , 1991, Archives of internal medicine.

[31]  Graves Ej,et al.  Detailed diagnoses and procedures, National Hospital Discharge Survey, 1994. , 1997, Vital and health statistics. Series 13, Data from the National Health Survey.

[32]  E. Graves Detailed diagnoses and procedures, National Hospital Discharge Survey, 1989. , 1991, Vital and health statistics. Series 13, Data from the National Health Survey.

[33]  R. Welling Pulmonary embolism and thrombophlebitis in the United States, 1970–1985: Gillum RF. Am Heart J 1987;114:1262-4 , 1989 .

[34]  Vitaland HealthStatistics Detailed diagnoses and procedures, National Hospital Discharge Survey, 1987. , 1989, Vital and health statistics. Series 13, Data from the National Health Survey.

[35]  D. Graham Detailed diagnoses and procedures for patients discharged from short-stay hospitals. , 1988, Vital and health statistics. Series 13, Data from the National Health Survey.

[36]  Hsia Dc,et al.  Accuracy of Diagnostic Coding for Medicare Patients under the Prospective-Payment System , 1988 .

[37]  W. M. Krushat,et al.  Accuracy of diagnostic coding for Medicare patients under the prospective-payment system. , 1988, The New England journal of medicine.

[38]  R. Gillum,et al.  Pulmonary embolism and thrombophlebitis in the United States, 1970-1985. , 1987, American heart journal.

[39]  E. Kinney Primer of Biostatistics , 1987 .

[40]  R. Pokras Detailed diagnoses and procedures for patients discharged from short-stay hospitals. United States, 1985. , 1987, Vital and health statistics. Series 13, Data from the National Health Survey.

[41]  A. Zárate Detailed diagnoses and procedures for patients discharged from short-stay hospitals. United States, 1984. , 1986, Vital and health statistics. Series 13, Data from the National Health Survey.

[42]  B. Haupt Detailed diagnoses and surgical procedures for patients discharged from short-stay hospitals. United States, 1983. , 1985, Vital and health statistics. Series 13, Data from the National Health Survey.

[43]  D W Simborg,et al.  DRG creep: a new hospital-acquired disease. , 1981, The New England journal of medicine.

[44]  A. Nicolaides,et al.  Clinical factors and the risk of deep venous thrombosis , 1975 .

[45]  J. Keller,et al.  Venous Thromboembolism and Other Venous Disease in the Tecumseh Community Health Study , 1973, Circulation.

[46]  S. Sevitt Venous Thrombosis and Pulmonary Embolism , 1970 .

[47]  W. Coon,et al.  Some epidemiologic considerations of thromboembolism. , 1959, Surgery, gynecology & obstetrics.

[48]  C. K. Kirby Venous thrombosis and pulmonary embolism. , 1946, The Surgical clinics of North America.