Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway

[1]  Ernst Hafen,et al.  The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway , 1994, Nature.

[2]  Michael C. Ostrowski,et al.  Persistent Activation of Mitogen-Activated Protein Kinases p42 and p44 and ets-2 Phosphorylation in Response to Colony-Stimulating Factor 1/c-fms Signaling , 1998, Molecular and Cellular Biology.

[3]  D. Ish-Horowicz,et al.  Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila , 2001, Nature.

[4]  W. Birchmeier,et al.  Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion , 1989, The Journal of cell biology.

[5]  P. Defossez,et al.  The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60. , 1997, Nucleic acids research.

[6]  A. Sharrocks,et al.  Integration of MAP kinase signal transduction pathways at the serum response element. , 1995, Science.

[7]  Michael C. Ostrowski,et al.  ets-2 Is a Target for an Akt (Protein Kinase B)/Jun N-Terminal Kinase Signaling Pathway in Macrophages ofmotheaten-viable Mutant Mice , 2000, Molecular and Cellular Biology.

[8]  D. Smith,et al.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. , 1988, Gene.

[9]  J. Gralla,et al.  Properties of initiator-associated transcription mediated by GAL4-VP16 , 1993, Molecular and cellular biology.

[10]  Peter J. Parker,et al.  The activation of phosphatidylinositol 3-kinase by Ras , 1994, Current Biology.

[11]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[12]  R. Muise-Helmericks,et al.  Signal transduction and the Ets family of transcription factors , 2000, Oncogene.

[13]  B. Vandenbunder,et al.  Sequential activation of ERK and repression of JNK by scatter factor/hepatocyte growth factor in madin-darby canine kidney epithelial cells. , 2000, Molecular biology of the cell.

[14]  G. V. Vande Woude,et al.  Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. Marshall,et al.  Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. , 1995, The EMBO journal.

[16]  B. Wasylyk,et al.  Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. , 1998, Trends in biochemical sciences.

[17]  B. Graves,et al.  Specificity within the ets family of transcription factors. , 1998, Advances in cancer research.

[18]  G L Johnson,et al.  Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.

[19]  Y. Takai,et al.  Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells , 1999, Oncogene.

[20]  A. Bardelli,et al.  Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. , 1991, The EMBO journal.

[21]  B. Vandenbunder,et al.  The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[22]  T. Yoshizaki,et al.  Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth , 2000, Oncogene.

[23]  K. Furge,et al.  Met receptor tyrosine kinase: enhanced signaling through adapter proteins , 2000, Oncogene.

[24]  C. Hänni,et al.  Molecular phylogeny of the ETS gene family , 1999, Oncogene.

[25]  Michael C. Ostrowski,et al.  Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 , 1996, Molecular and cellular biology.

[26]  N. Kitamura,et al.  Requirement of regulated activation of Ras for response of MDCK cells to hepatocyte growth factor/scatter factor. , 2000, Experimental cell research.

[27]  Michael C. Ostrowski,et al.  Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor , 1995, Molecular and cellular biology.

[28]  B. Vandenbunder,et al.  The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. , 1999, Molecular biology of the cell.

[29]  R. Treisman Ternary complex factors: growth factor regulated transcriptional activators. , 1994, Current opinion in genetics & development.

[30]  P. Comoglio,et al.  Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells , 1995, Molecular and cellular biology.

[31]  A. Ridley,et al.  Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. , 1998, Molecular biology of the cell.

[32]  J. Downward,et al.  Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway* , 1998, The Journal of Biological Chemistry.

[33]  W. Birchmeier,et al.  The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells , 1993, The Journal of cell biology.

[34]  T. Nakamura,et al.  Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. , 1984, Biochemical and biophysical research communications.

[35]  Gerald M. Rubin,et al.  The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway , 1994, Cell.

[36]  L. McIntosh,et al.  Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[37]  A. Sharrocks,et al.  Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1 , 1998, The EMBO journal.

[38]  P. Cohen,et al.  Activation of the MAP kinase pathway by the protein kinase raf , 1992, Cell.