The role of iodine in hypersensitivity reactions to radio contrast media

Introduction Hypersensitivity reactions to iodinated radio contrast media (RCM) are either immediate‐type (IT) or delayed reactions (DT). In IT, the pathomechanism is unclear. In DT, delayed positive patch (PT) and intradermal tests (IDT) and RCM‐specific T cells suggest a T cell‐mediated mechanism. In both, the role of iodine has not been clarified; however, patients are often labelled as ‘iodine allergic’. Occasionally, positive skin tests to iodine‐containing drugs are observed.

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