Senile cataracts and the HLA system.

HLA A, B, and C typing was performed on a group of 309 southern Spanish people, namely, 207 controls and 102 patients who underwent a senile cataract extraction. Comparison of the results in the 2 groups (chi-square test) showed in the senile cataract group a significant increase in the association with HLA A9 (p<001), HLA A blank (p<0-005), HLA B5 (p<OS005), HLA B13 (p<003), and HLA B blank (p<001) and a significant decrease in the association with HLA A2 (p<005), HLA Aw24 (p<0-001), HLA B27 (p<O 025), HLA Cw2 (p<0001), and HLA Cw5 (p<O-Ol). The factors underlying these increased and decreased associations are conjectural.

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