Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.

[1]  J. Hamilton,et al.  The identification of (3R,4S)-5-fluoro-5-deoxy-D-ribulose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya. , 2007, Bioorganic chemistry.

[2]  F. Diederich,et al.  Fluorine in Pharmaceuticals: Looking Beyond Intuition , 2007, Science.

[3]  William Fenical,et al.  Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica , 2007, Proceedings of the National Academy of Sciences.

[4]  B. Moore,et al.  Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. , 2007, Organic letters.

[5]  Sy Teisan,et al.  Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. , 2007, Journal of natural products.

[6]  C. Walsh,et al.  Nature's inventory of halogenation catalysts: oxidative strategies predominate. , 2006, Chemical reviews.

[7]  R. Huber,et al.  Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. , 2006, Journal of the American Chemical Society.

[8]  Hiroshi Yasui,et al.  A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. , 2005, Cancer cell.

[9]  William Fenical,et al.  Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae. , 2005, International journal of systematic and evolutionary microbiology.

[10]  T. Ashton,et al.  An improved synthesis of 5'-fluoro-5'-deoxyadenosines. , 2005, Bioorganic & medicinal chemistry letters.

[11]  P. Williams,et al.  New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. , 2005, The Journal of organic chemistry.

[12]  S. Neuteboom,et al.  Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. , 2005, Journal of medicinal chemistry.

[13]  R. Süssmuth,et al.  Mutational biosynthesis—a tool for the generation of structural diversity in the biosynthesis of antibiotics , 2005, Applied Microbiology and Biotechnology.

[14]  H. Oikawa,et al.  The Leptomycin Gene Cluster and Its Heterologous Expression in Streptomyces lividans , 2005, The Journal of Antibiotics.

[15]  D. O'Hagan,et al.  Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. , 2004, Natural product reports.

[16]  Martin Stahl,et al.  Fluorine in Medicinal Chemistry , 2004, Chembiochem : a European journal of chemical biology.

[17]  J. Naismith,et al.  Crystal structure and mechanism of a bacterial fluorinating enzyme , 2004, Nature.

[18]  T. Mincer,et al.  Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. , 2003, Angewandte Chemie.

[19]  P. Elliott,et al.  Proteasome inhibition measurements: clinical application. , 2000, Clinical chemistry.

[20]  L. Dick,et al.  Kinetic characterization of the chymotryptic activity of the 20S proteasome. , 1996, Biochemistry.

[21]  B. Moore,et al.  Discovery and characterization of a marine bacterial SAM-dependent chlorinase. , 2008, Nature chemical biology.

[22]  Bradley S Moore,et al.  Biosynthesis and attachment of novel bacterial polyketide synthase starter units. , 2002, Natural product reports.