European Respiratory Society International Congress 2017: highlights from the Clinical Assembly

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its six respective groups) that were presented at the 2017 European Respiratory Society International Congress in Milan, Italy. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, the newest research and actual data as well as award-winning abstracts and highlight sessions will be discussed. A highlights review of selected presentations from #ERSCongress 2017 by the @ERStalk Clinical Assembly http://ow.ly/p3fB30gSb24

[1]  N. Koulouris,et al.  Impact of Depression on Patients With Idiopathic Pulmonary Fibrosis , 2020, Frontiers in Medicine.

[2]  C. Juhl,et al.  Early pulmonary rehabilitation after acute exacerbation of COPD: a randomised controlled trial , 2020, ERJ Open Research.

[3]  M. Košnik,et al.  Peripheral Blood Eosinophils as Marker of Sputum Eosinophilia and Outcome of COPD Exacerbation , 2019, Acta Medica Saliniana.

[4]  L. Molina,et al.  Is iron deficiency modulating physical activity in COPD? , 2019, International journal of chronic obstructive pulmonary disease.

[5]  C. Schumann,et al.  A double-blind, randomized, sham-controlled study of Targeted Lung Denervation in patients with moderate to severe COPD , 2018, Interventional Pulmonology.

[6]  P. Nguyen,et al.  Use of Ventilation-Perfusion Single-Photon Emission Computed Tomography (VQ SPECT) to Select the Target Lobe for Endobronchial Valves Lung Volume Reduction (EBV-LVR) , 2018, Interventional Pulmonology.

[7]  A. Abernethy,et al.  Regular extended release morphine for chronic breathlessness: a multi-centre double-blind RCT , 2018, Rehabilitation and Chronic Care.

[8]  G. Criner,et al.  Late Breaking Abstract - Endobronchial Valves for Severe Emphysema – 12-month Results of the EMPROVE Trial , 2018, Interventional Pulmonology.

[9]  D. Nowak,et al.  Effectiveness of Pulmonary Rehabilitation for Patients with Asthma: EPRA-RCT , 2018, Rehabilitation and Chronic Care.

[10]  S. Muro,et al.  Association of airways visibility on computed tomography with symptoms and lung function in COPD , 2018, Imaging.

[11]  L. Verdijk,et al.  Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD , 2018, Rehabilitation and Chronic Care.

[12]  S. Kon,et al.  Five-repetition sit-to-stand and mortality in COPD: a prospective cohort study , 2018, Rehabilitation and Chronic Care.

[13]  U. Zaleska-Dorobisz,et al.  Quantitative computed tomography imaging in asthma and chronic obstructive pulmonary disease. , 2018, Imaging.

[14]  R. Huebner,et al.  Characterization of Chartis Phenotypes based on fissure completeness scores , 2018, Interventional Pulmonology.

[15]  J. Annema,et al.  Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT) , 2018, Interventional Pulmonology.

[16]  J. Hohlfeld,et al.  Regional detection of edema following segmental LPS challenge using functional MR imaging , 2018, Imaging.

[17]  J. Annema,et al.  Airway smooth muscle mass reduction after Bronchial Thermoplasty in asthmatics correlates with FEV1. , 2018, Interventional Pulmonology.

[18]  O. Vaarala,et al.  Using DPM CT analysis to assess the contribution of small airways disease in COPD , 2018, Imaging.

[19]  D. Fielding,et al.  Bronchodilator responsiveness as a success predictor for bronchial thermoplasty , 2018, Interventional Pulmonology.

[20]  N. Molinari,et al.  Pericyte coverage of skeletal muscle capillaries is impaired during training-induced angiogenesis in COPD patients , 2018, Rehabilitation and Chronic Care.

[21]  R. Rodríguez-Roisín,et al.  Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial , 2018, European Respiratory Journal.

[22]  P. Paré,et al.  Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study. , 2018, The Lancet. Respiratory medicine.

[23]  F. Martinez,et al.  Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events. A Post Hoc Cohort Analysis from the SUMMIT Randomized Clinical Trial , 2018, American journal of respiratory and critical care medicine.

[24]  J. M. Salge,et al.  Exercise Improves Physical Activity and Comorbidities in Obese Adults with Asthma , 2018, Medicine and science in sports and exercise.

[25]  E. Vicaut,et al.  Feasibility of Bioengineered Tracheal and Bronchial Reconstruction Using Stented Aortic Matrices , 2018, JAMA.

[26]  A. Sung,et al.  A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE) , 2018, American journal of respiratory and critical care medicine.

[27]  K. Rabe,et al.  Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma , 2018, The New England journal of medicine.

[28]  I. Pavord,et al.  Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma , 2018, The New England journal of medicine.

[29]  E. Bateman,et al.  As‐Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma , 2018, The New England journal of medicine.

[30]  E. Bateman,et al.  Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma , 2018, The New England journal of medicine.

[31]  Geoffrey H. Donovan,et al.  Vegetation diversity protects against childhood asthma: results from a large New Zealand birth cohort , 2018, Nature Plants.

[32]  Mei Jiang,et al.  Tai Chi and Pulmonary Rehabilitation Compared for Treatment‐Naive Patients With COPD: A Randomized Controlled Trial , 2018, Chest.

[33]  J. Wedzicha,et al.  Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial. , 2018, The Lancet. Respiratory medicine.

[34]  J. Hohlfeld,et al.  Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. , 2018, The Lancet. Respiratory medicine.

[35]  Meilan K. Han,et al.  Once‐Daily Single‐Inhaler Triple versus Dual Therapy in Patients with COPD , 2018, The New England journal of medicine.

[36]  N. Roche,et al.  Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial , 2018, The Lancet.

[37]  M. Cabana,et al.  Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations , 2018, The New England journal of medicine.

[38]  I. Pavord,et al.  Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations , 2018, The New England journal of medicine.

[39]  J. Bourbeau,et al.  COMET: a multicomponent home-based disease-management programme versus routine care in severe COPD , 2018, European Respiratory Journal.

[40]  I. Pavord,et al.  Physiotherapy breathing retraining for asthma: a randomised controlled trial , 2018, The Lancet. Respiratory medicine.

[41]  G. Hillerdal,et al.  A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (TRANSFORM) , 2017, American journal of respiratory and critical care medicine.

[42]  H. Krumholz,et al.  Risk Trajectories of Readmission and Death in the First Year after Hospitalization for Chronic Obstructive Pulmonary Disease , 2017, American journal of respiratory and critical care medicine.

[43]  J. Brugada,et al.  Lung function in early adulthood and health in later life: a transgenerational cohort analysis. , 2017, The Lancet. Respiratory medicine.

[44]  C. Moor,et al.  Clubbing in patients with fibrotic interstitial lung diseases. , 2017, Respiratory medicine.

[45]  I. Pavord,et al.  Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease , 2017, The New England journal of medicine.

[46]  M. Kreuter,et al.  Pharmacokinetics (PK) of nintedanib with add-on pirfenidone in patients with idiopathic pulmonary fibrosis (IPF): results from INJOURNEY , 2017, Pneumologie.

[47]  F. Martinez,et al.  GOLD-associated shape variations in central airway tree assessed via QCT , 2017 .

[48]  J. Annema,et al.  Needle based confocal laser endomicroscopy for lung cancer staging , 2017 .

[49]  Sally J. Singh,et al.  Telephone health coaching in primary care patients with MRC I/II COPD: randomised controlled trial , 2017 .

[50]  D. F. Nuñez,et al.  Rituximab improves interstitial lung disease in rheumatoid arthritis patients , 2017 .

[51]  H. Watz,et al.  The survival effect of physical activity in patients with COPD: every step counts , 2017 .

[52]  F. Herth,et al.  Reduction of bronchial wall thickness and hyperinflation on quantitative CT after bronchial thermoplasty for severe asthma , 2017 .

[53]  I. Vogiatzis,et al.  Effect of high intensity interval exercise rehabilitation in cystic fibrosis , 2017 .

[54]  J. Annema,et al.  Complete endosonographic nodal staging of lung cancer in patients eligible for stereotactic ablative radiotherapy (STAGE study NCT02997449) , 2017 .

[55]  G. Raghu,et al.  PRAISE, a randomized, placebo-controlled, double-blind Phase 2 clinical trial of pamrevlumab (FG-3019) in IPF patients , 2017 .

[56]  C. Nolan,et al.  Response to pulmonary rehabilitation (PR) in bronchiectasis and COPD: a propensity matched analysis , 2017 .

[57]  P. Foster,et al.  IL-27 and asthma endotypes- Is there a connection , 2017 .

[58]  T. Velikova,et al.  Serum levels of IL-6 in adult patients with moderate to severe asthma , 2017 .

[59]  I. Pavord,et al.  Blood eosinophils and lung function decline in young adults , 2017 .

[60]  P. Luburich,et al.  Benefits from a program for “early interstitial lung diseases” in primary care centers , 2017 .

[61]  S. Pchelina,et al.  Association between AGTTGFB1ESR1, and VDR gene variants with idiopathic pulmonary fibrosis (IPF) and pulmonary sarcoidosis (PS) clinical features , 2017 .

[62]  M. Cazzola,et al.  LABA/LAMA combination, exercise and lung hyperinflation in COPD: a meta-analysis , 2017 .

[63]  K. Nishimura,et al.  Comparison between electronic and paper versions of the Evaluating Respiratory Symptoms in COPD (E-RS) and the COPD Assessment Test (CAT) , 2017 .

[64]  J. Wild,et al.  Comparison of in-vivo lung morphometry models from multiple b-value diffusion-weighted MRI in healthy controls, IPF and COPD patients , 2017 .

[65]  I. Pavord,et al.  Association between blood eosinophil count and risk of exacerbations in patients with COPD , 2017 .

[66]  T. Brack,et al.  A prediction model for exacerbations in patients with COPD generated in a Swiss multicenter COPD cohort study (TOPDOCS) , 2017 .

[67]  L. Salawu,et al.  The relationship of serum interleukin-13 to asthma control in a sample of nigerian asthmatics , 2017 .

[68]  N. Chavannes,et al.  Selfmanagement by eHealth in asthma and COPD patients: with or without the professional , 2017 .

[69]  A. Prasse,et al.  Gender associated Differences in Patients with IPF based on the Analysis of the INSIGHTS-IPF Registry Data , 2017 .

[70]  R. Pandey,et al.  The effects of pulmonary rehabilitation in patients with non-cystic fibrosis bronchiectasis- A randomised controlled trial , 2017 .

[71]  S. Julious,et al.  A systematic review to identify and weight indicators of risk of asthma exacerbations in children aged 5-12 , 2017 .

[72]  R. Perona,et al.  Post-transplant morbidity and mortality in patients with pulmonary fibrosis and telomeric shortening , 2017 .

[73]  Qingzhu Sun,et al.  Late Breaking Abstract - Bronchial Thermoplasty restores constitutive high PRMT1 expression in asthmatic airways , 2017 .

[74]  T. Miyazawa,et al.  The ratio of cardiac/lung area in expiratory plain chest radiographs correlates with the level of airflow limitation in patients with severe COPD , 2017 .

[75]  S. Miescher,et al.  Alpha1-Antitrypsin reduces endoplasmic reticulum stress, inflammatory cytokines and improves wound repair in alveolar epithelial cells of fibrotic lung in vitro , 2017 .

[76]  S. Walsh,et al.  Novel CT markers of volume loss in idiopathic pulmonary fibrosis (IPF) predict mortality , 2017 .

[77]  R. Kozu,et al.  Effects of mean pulmonary arterial pressure and supplemental oxygen on exercise capacity in IPF patients with exercise-induced hypoxemia , 2017 .

[78]  K. Theander,et al.  A description of requests for self-management support among patients with COPD in Primary Health Care , 2017 .

[79]  C. Fujisawa,et al.  Relationship between physical activity, muscle thickness, and echo intensity in patients with chronic obstructive pulmonary disease: a cross-sectional study , 2017 .

[80]  B. Kirenga,et al.  The development and implementation of a lung health awareness programme in a rural district of Uganda , 2017 .

[81]  Charlotte C Poot,et al.  Beliefs and behaviours towards chronic lung disease - a mixed-method FRESH AIR study , 2017 .

[82]  L. Boulet,et al.  MUC5AC expression decrease correlates with the decline in rates of severe asthma exacerbations post bronchial thermoplasty , 2017 .

[83]  J. Svancara,et al.  Discordance between a patient completed COPD Assessment test (CAT) and a CAT completed by patient with physician assistance , 2017 .

[84]  M. Puhan,et al.  The longitudinal association of daily physical activity and symptoms of exacerbations in COPD patients , 2017 .

[85]  C. Dooms,et al.  Complete and systematic mediastinal nodal staging for lung cancer (SCORE study) , 2017 .

[86]  T. Schermer,et al.  Personalised prediction of future risk using early treatment response , 2017 .

[87]  Sally J. Singh,et al.  An exploration of physical activity and sedentary behaviour during hospitalisation for acute exacerbation of chronic respiratory diseases , 2017 .

[88]  N. Chavannes,et al.  Late Breaking Abstract - Health economic burden of asthma/COPD in Uganda, Vietnam, Kyrgyzstan and Greece : FRESH AIR results , 2017 .

[89]  F. Albers,et al.  Late Breaking Abstract - Mepolizumab reduces exacerbations in eosinophilic COPD , 2017 .

[90]  A. Biancardi,et al.  Ventilation heterogeneity assessed in patients with mild cystic fibrosis and asthma using Hyperpolarised gas MRI histogram analysis , 2017 .

[91]  I. Pavord,et al.  Association between blood eosinophil count and exacerbation risk in patients with asthma receiving medium- or high-dosage inhaled corticosteroids , 2017 .

[92]  A. Hayen,et al.  Disease progression at 12 months does not predict future outcomes in IPF patients: Analysis from the Australian IPF Registry , 2017 .

[93]  J. Annema,et al.  Airway smooth muscle mass reduction after Bronchial Thermoplasty; the TASMA randomized controlled trial , 2017 .

[94]  J. Goldin,et al.  Late Breaking Abstract - Responder phenotyping using functional respiratory imaging (FRI) in IPF patients treated with anti-CGTG monoclonal antibody FG3019 , 2017 .

[95]  G. Parraga,et al.  Ventilation heterogeneity reversibility: asthma, COPD or ACOS? , 2017 .

[96]  J. Schwartz,et al.  An observational study on the effect of air pollution on the incidence of idiopathic pulmonary fibrosis in Italy , 2017 .

[97]  G. Downey,et al.  Protein tyrosine phosphatase-alpha (PTPα) promotes profibrotic responses in lung fibroblasts , 2017 .

[98]  R. Stelmach,et al.  Identification of phenotypes in COPD patients: influence of physical activity in daily life, body composition and skeletal muscle strength , 2017 .

[99]  A. O'Mahony,et al.  Rituximab in the management of idiopathic inflammatory myopathies complicated by interstitial lung disease , 2017 .

[100]  C. Dirksen,et al.  Discrepancy between patient expectations and experiences with anti-fibrotic drugs in idiopathic pulmonary fibrosis , 2017 .

[101]  M. Bajc,et al.  High CAT score predicts lung parenchymal damage in COPD , 2017 .

[102]  G. Collins,et al.  Late Breaking Abstract - Prognostic and therapeutic markers of malignant pleural effusion – The PROMISE study , 2017 .

[103]  N. Chavannes,et al.  Effect on health status of integrated self-management platforms in COPD disease-management , 2017 .

[104]  D. Lynch,et al.  The variable relationship between changes in lung density and FEV1 in smokers , 2017 .

[105]  A. Warth,et al.  Real world experience with transbronchial cryobiopsies for diagnosing interstitial lung disease (ILD) , 2017 .

[106]  M. Coertjens,et al.  Relationship between stair climbing test and locomotor parameters after Pulmonary Rehabilitation , 2017 .

[107]  P. Mota,et al.  Transbronchial Criobiopsy (TCB) In Two Lung Lobes- Diagnostic Accuracy , 2017 .

[108]  C. Nolan,et al.  Unsupervised home-based versus supervised outpatient pulmonary rehabilitation (PR) in COPD: a propensity-matched, non-inferiority analysis , 2017 .

[109]  M. Hew,et al.  Ethnic differences in asthma management in Australia , 2017 .

[110]  J. Annema,et al.  Visualizing the alveolar compartment in ILD patients by Optical Coherence Tomography , 2017 .

[111]  F. Mateos,et al.  Prevalence of traffic accidents in patients diagnosed with asthma and/or rhinitis , 2017 .

[112]  C. Bai,et al.  The REACH study, a randomized controlled trial assessing the safety and effectiveness of the Spiration Valve System endobronchial therapy for severe emphysema: 12 month follow-up results , 2017 .

[113]  N. Chavannes,et al.  Identifying cut off scores for the chronic obstructive pulmonary disease assessment test (CAT) to predict exacerbations in COPD , 2017 .

[114]  C. Brightling,et al.  Parametric response map registered CT feature and small airway physiology analysis in asthma , 2017 .

[115]  P. Śliwiński,et al.  Idiopathic pulmonary fibrosis (IPF) patients in Poland – preliminary cohort analysis of EMPIRE registry , 2017 .

[116]  H. Marshall,et al.  Late Breaking Abstract - Hyperpolarised gas MRI demonstrates sub-clinical progression in IPF over 6 months , 2017 .

[117]  M. Tripathi,et al.  68 Gallium DOTA-NOC PET/CT as a predictor of disease activity in sarcoidosis , 2017 .

[118]  T. Gislason,et al.  Asthma and COPD overlap syndrome (ACOS) is related to a high burden of sleep disturbance and respiratory symptoms: results from the RHINE and Swedish GA2LEN surveys , 2017 .

[119]  H. Watz,et al.  ACTIVATE: effect of aclidinium/formoterol on physical activity in patients with COPD , 2017 .

[120]  I. Pavord,et al.  Breathing exercises for asthma - results of the BREATHE study , 2017 .

[121]  A. Tjønneland,et al.  Determinants of incident asthma-COPD overlap compared to asthma and COPD alone: A prospective study of 55,110 middle-aged adults , 2017 .

[122]  F. Herth,et al.  Comparison of quantitative CT (QCT) with Chartis measurement to assess collateral ventilation as predictor of success in endoscopic lung volume reduction with valves , 2017 .

[123]  J. Stauffer,et al.  Late Breaking Abstract - Long-term safety of pirfenidone in a real-world setting: final results from the prospective, observational PASSPORT registry , 2017 .

[124]  M. D’Amato,et al.  Role of the inflammasome in idiopathic pulmonary fibrosis , 2017 .

[125]  Mark G. Jones,et al.  Accuracy Of A Clinical Diagnosis Of Idiopathic Pulmonary Fibrosis: A Study Of 275 Pulmonologists From 54 Countries , 2017 .

[126]  N. Shime,et al.  Extracorporeal membrane oxygenation for the treatment of acute exacerbation of interstitial lung diseases , 2017 .

[127]  P. Cullinan,et al.  Anxiety and depression in idiopathic pulmonary fibrosis (IPF): prevalence and clinical correlates , 2017 .

[128]  B. Bennett,et al.  Late Breaking Abstract - Evaluation of the JNK inhibitor, CC-90001, in a phase 1b pulmonary fibrosis trial , 2017 .

[129]  M. Košnik,et al.  Peripheral Blood Eosinophils as Marker of Sputum Eosinophilia and Outocome of COPD Exacerbation , 2017 .

[130]  L. Molina,et al.  Is iron deficiency modulating physical activity in COPD , 2017 .

[131]  I. Struman,et al.  Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis , 2017, Clinical Epigenetics.

[132]  C. Mcevoy,et al.  Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies , 2017, European Respiratory Journal.

[133]  F. Martinez,et al.  Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case–cohort study , 2017, European Respiratory Journal.

[134]  Sally J. Singh,et al.  Comparison of a structured home-based rehabilitation programme with conventional supervised pulmonary rehabilitation: a randomised non-inferiority trial , 2017, Thorax.

[135]  Todor A Popov,et al.  Blood eosinophil count and exacerbation risk in patients with COPD , 2017, European Respiratory Journal.

[136]  R. Bals,et al.  Cerebral cortex blood flow response to exercise in COPD patients with and without cognitive impairment , 2017 .

[137]  J. Ryu,et al.  Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease: Retrospective Analysis of 74 Cases , 2017, Chest.

[138]  L. Boulet,et al.  Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma , 2017, JAMA.

[139]  E. V. van Rikxoort,et al.  Predicting Lung Volume Reduction after Endobronchial Valve Therapy Is Maximized Using a Combination of Diagnostic Tools , 2016, Respiration.

[140]  T. Verheij,et al.  Overdiagnosis of asthma in children in primary care: a retrospective analysis. , 2016, The British journal of general practice : the journal of the Royal College of General Practitioners.

[141]  N. Krug,et al.  Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers. , 2015, Pulmonary pharmacology & therapeutics.

[142]  Augustine S. Lee,et al.  Transbronchial cryobiopsy in diffuse parenchymal lung disease , 2015 .

[143]  L. Konge,et al.  Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer , 2015, European Respiratory Journal.

[144]  A. Valipour,et al.  Targeted lung denervation for moderate to severe COPD: a pilot study , 2015, Thorax.

[145]  Gregory G King,et al.  Advanced imaging in COPD: insights into pulmonary pathophysiology. , 2014, Journal of thoracic disease.

[146]  F. Laurent,et al.  Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT , 2012, Pulmonary medicine.

[147]  H. Kauczor,et al.  Computed Tomographic Imaging of the Airways in COPD and Asthma , 2011, Journal of thoracic imaging.

[148]  A. Holland,et al.  The effects of pulmonary rehabilitation in patients with non-cystic fibrosis bronchiectasis: protocol for a randomised controlled trial , 2010, BMC pulmonary medicine.

[149]  Mario Castro,et al.  Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. , 2010, American journal of respiratory and critical care medicine.

[150]  A. Azuma,et al.  [Idiopathic pulmonary fibrosis (IPF)]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[151]  P. Gibson,et al.  Written action plans for asthma: an evidence-based review of the key components , 2004, Thorax.

[152]  R. Balbontín,et al.  [Interstitial lung diseases]. , 1985, Revista medica de Chile.

[153]  R. Marçôa,et al.  Diagnostic yield of transbronchial lung cryobiopsy in interstitial lung diseases. , 2017, Revista portuguesa de pneumologia.

[154]  J. John,et al.  Family intervention for intellectually disabled children , 1999, British Journal of Psychiatry.

[155]  L. Moreland Interstitial lung disease (ILD) , 2004 .