Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

[1]  K. Kagawa,et al.  Neutrophil to lymphocyte ratio predicts prognosis in unresectable pancreatic cancer , 2020, Scientific Reports.

[2]  D. Marks,et al.  Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer , 2020, Glia.

[3]  C. Prado,et al.  Nutrition interventions to treat low muscle mass in cancer , 2020, Journal of cachexia, sarcopenia and muscle.

[4]  L. Coussens,et al.  The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer , 2019, Nature Communications.

[5]  Magdalena Ogluszka,et al.  Evaluate Cutpoints: Adaptable continuous data distribution system for determining survival in Kaplan-Meier estimator , 2019, Comput. Methods Programs Biomed..

[6]  Alexander Lercher,et al.  CD8+ T cells induce cachexia during chronic viral infection , 2019, Nature Immunology.

[7]  R. Dantzer,et al.  Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior , 2019, Psychopharmacology.

[8]  D. Marks,et al.  MyD88 signalling is critical in the development of pancreatic cancer cachexia , 2019, Journal of cachexia, sarcopenia and muscle.

[9]  D. Marks,et al.  TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia , 2018, Brain, Behavior, and Immunity.

[10]  D. Cunningham,et al.  Identifying the role of neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio as prognostic markers in patients undergoing resection of pancreatic ductal adenocarcinoma , 2018, Annals of hepato-biliary-pancreatic surgery.

[11]  Albert C. Koong,et al.  Altered exocrine function can drive adipose wasting in early pancreatic cancer , 2018, Nature.

[12]  Derek J. Wilson,et al.  Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes , 2018, Proceedings of the National Academy of Sciences.

[13]  M. Korc,et al.  Cancer-associated cachexia , 2018, Nature Reviews Disease Primers.

[14]  T. Tsuji,et al.  Anamorelin (ONO‐7643) for the treatment of patients with non–small cell lung cancer and cachexia: Results from a randomized, double‐blind, placebo‐controlled, multicenter study of Japanese patients (ONO‐7643‐04) , 2017, Cancer.

[15]  K. Nakao,et al.  Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice , 2017, Scientific Reports.

[16]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[17]  Chie Nagata,et al.  Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis. , 2017, Lung cancer.

[18]  Yong Zhou,et al.  Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 , 2017, Nature Communications.

[19]  D. Lobo,et al.  Body composition measurement using computed tomography: Does the phase of the scan matter? , 2017, Nutrition.

[20]  D. Marks,et al.  Establishment and characterization of a novel murine model of pancreatic cancer cachexia , 2017, Journal of cachexia, sarcopenia and muscle.

[21]  W. Niessen,et al.  Contrast-enhancement influences skeletal muscle density, but not skeletal muscle mass, measurements on computed tomography. , 2017, Clinical nutrition.

[22]  D. Currow,et al.  The emerging role of anamorelin hydrochloride in the management of patients with cancer anorexia-cachexia. , 2017, Future oncology.

[23]  R. Hwang,et al.  Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment. , 2017, Cancer research.

[24]  H. Tilg,et al.  Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation , 2017, Trends in Endocrinology & Metabolism.

[25]  Yan Shi,et al.  Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma , 2017, Scientific Reports.

[26]  M. Rubin,et al.  MC4R-dependent suppression of appetite by bone-derived lipocalin 2 , 2017, Nature.

[27]  Y. Asmann,et al.  Lipocalin-2 protects the brain during inflammatory conditions , 2017, Molecular Psychiatry.

[28]  D. Fearon,et al.  Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity , 2016, Cell metabolism.

[29]  V. Slavkovich,et al.  Disposal of iron by a mutant form of lipocalin 2 , 2016, Nature Communications.

[30]  M. Watt,et al.  Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia. , 2016, Cancer research.

[31]  Martin Jägersand,et al.  Body Composition Assessment in Axial CT Images Using FEM-Based Automatic Segmentation of Skeletal Muscle , 2016, IEEE Transactions on Medical Imaging.

[32]  A. Scott,et al.  Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival , 2015, Cell.

[33]  Zongguang Zhou,et al.  Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis , 2015, Scientific Reports.

[34]  S. Groshen,et al.  A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. , 2015, Cell metabolism.

[35]  A. Goldberg,et al.  Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy , 2015, Nature Communications.

[36]  J. Jonkers,et al.  IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis , 2015, Nature.

[37]  B. Porse,et al.  Liver is the major source of elevated serum lipocalin‐2 levels after bacterial infection or partial hepatectomy: A critical role for IL‐6/STAT3 , 2015, Hepatology.

[38]  B. Kahn,et al.  Lipid Extraction from Mouse Feces. , 2015, Bio-protocol.

[39]  Satchidananda Panda,et al.  Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. , 2014, Cell metabolism.

[40]  S. Anker,et al.  Prevalence, incidence and clinical impact of cachexia: facts and numbers—update 2014 , 2014, Journal of cachexia, sarcopenia and muscle.

[41]  D. Bernlohr,et al.  Lipocalin 2 Expression and Secretion Is Highly Regulated by Metabolic Stress, Cytokines, and Nutrients in Adipocytes , 2014, PloS one.

[42]  G. Ramadori,et al.  Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. , 2014, World journal of gastroenterology.

[43]  Peng Zhao,et al.  The Induction of Lipocalin-2 Protein Expression in Vivo and in Vitro * , 2014, The Journal of Biological Chemistry.

[44]  S. Skvortsov,et al.  Lipocalin-2 Expressed in Innate Immune Cells Is an Endogenous Inhibitor of Inflammation in Murine Nephrotoxic Serum Nephritis , 2013, PloS one.

[45]  K. Boyd,et al.  Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[46]  F. Tacke,et al.  Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis. , 2013, Biochimica et biophysica acta.

[47]  Satchidananda Panda,et al.  Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. , 2012, Cell metabolism.

[48]  E. Rosen,et al.  A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance. , 2011, American journal of physiology. Endocrinology and metabolism.

[49]  Paula Ravasco,et al.  Definition and classification of cancer cachexia: an international consensus. , 2011, The Lancet. Oncology.

[50]  T. Mak,et al.  Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. , 2010, The Journal of clinical investigation.

[51]  Wendy S. Wright,et al.  Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice , 2010, Diabetes.

[52]  T. Mak,et al.  Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity , 2010, Diabetes.

[53]  L. Birdsell,et al.  The emerging role of computerized tomography in assessing cancer cachexia , 2009, Current opinion in supportive and palliative care.

[54]  K. Dickstein,et al.  Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. , 2009, European heart journal.

[55]  Tony Reiman,et al.  A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. , 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[56]  Tony Reiman,et al.  Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. , 2008, The Lancet. Oncology.

[57]  H. Friess,et al.  Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer , 2008, Journal of Gastrointestinal Surgery.

[58]  F. Schmidt Meta-Analysis , 2008 .

[59]  R. Cone,et al.  Mechanisms of Disease: cytokine and adipokine signaling in uremic cachexia , 2006, Nature Clinical Practice Nephrology.

[60]  R. Hruban,et al.  Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.

[61]  R. Cone Anatomy and regulation of the central melanocortin system , 2005, Nature Neuroscience.

[62]  Shizuo Akira,et al.  Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron , 2004, Nature.

[63]  D. Persons,et al.  Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[64]  G. Yancopoulos,et al.  The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. , 2004, Molecular cell.

[65]  Marco Sandri,et al.  Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy , 2004, Cell.

[66]  A. Goldberg,et al.  Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[67]  D J Glass,et al.  Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy , 2001, Science.

[68]  H. Sengeløv,et al.  Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. , 1994, Biochemical and biophysical research communications.

[69]  H. Sengeløv,et al.  Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. , 1994, Blood.

[70]  S. Leeder,et al.  A population based study , 1993, The Medical journal of Australia.

[71]  H. Sengeløv,et al.  Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. , 1993, The Journal of biological chemistry.

[72]  The International Consensus , 1992, The Rights of the Child and the Changing Image of Childhood.

[73]  A. Katz,et al.  DISEASE OF THE HEART IN THE WORKS OF HIPPOCRATES , 1962, British heart journal.