A COMPARATIVE EVALUATION OF GABAPENTIN AND CLONIDINE PREMEDICATION ON POST OPERATIVE ANALGESIA REQUIREMENT FOLLOWING ABDOMINAL SURGERIES UNDER GENERAL ANAESTHESIA

AIM: Aim of our study was to compare the relative effectiveness of gabapentin and clonidine premedication on patients undergoing elective abdominal surgeries under G.A. OBJECTIVE: gabapentine and clonidine have anti-nociceptive properties .This study assess their efficacy in prolonging the analgesic effect intra-operative and postoperative analgesic requirement. MATERIAL AND METHOD: 225 patients of either sex of age between 20-60 years, ASA grade I & II, patient admitted to Hamidia hospital for elective abdominal surgeries under general anaesthesia were included in the study. The patients were randomly allocated into three groups 75 each group I : Control group (patients received placebo tablet at 90 min before the surgery),group II Gabapentin 300 mg tablet orally 90 min before surgery ,groupIII:clonidine150µg tablet orally given 90 min before surgery. Duration of postoperative analgesia, Degree of postoperative pain (VAS score)and added rescue analgesia required in 24 hrs were recorded postoperatively. RESULT: Analysis reveled that there was no difference in the HR, SBP among the three group during the study. Duration of postoperative analgesia, observed from time of reversal to first demand of analgesia in the recovery room was more in group II compared to group I and group III (p-value <0.001, highly significant). Pain perception was highly blunted in groups II compared to group I & group III. Total rescue analgesic requirement during the postoperative 24hrs period was much lower in group II inj Diclofenac compared to group I and group III . ( p-value < 0.001, highly significant).CONCLUSION: Given 90 min before induction of GA oral gabapentin(300 mg) or clonidine(150 µg) preoperatively was effective in lowering postoperative VAS pain score and consumption of analgesics, it was also shows that gabapentin significantly decreases postoperative pain intensity and analgesic consumption after abdominal surgeries.

[1]  Sarita Sharma,et al.  Comparative Evaluation Of Gabapentin, Clonidine And Combination Of Both The Drugs To Attenuate The Pressor Response To Direct Laryngoscopy And Intubation. , 2012 .

[2]  M. Akrami,et al.  Preoperative gabapentin or clonidine decreases postoperative pain and morphine consumption after abdominal hysterectomy. , 2009 .

[3]  S. Mohammadi,et al.  Comparing oral gabapentin versus clonidine as premedication on early postoperative pain, nausea and vomiting following general anesthesia , 2009 .

[4]  Donghyun Kim,et al.  The effectiveness of gabapentin on post-tonsillectomy pain control , 2009, European Archives of Oto-Rhino-Laryngology.

[5]  V. Arora,et al.  Preemptive Gabapentin vs Pregabalin for Acute Postoperative Pain after Surgery under Spinal Anaesthesia , 2008 .

[6]  O. Mathiesen,et al.  Gabapentin and postoperative pain: a qualitative and quantitative systematic review, with focus on procedure , 2007, BMC anesthesiology.

[7]  A. Paraskeva,et al.  Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation. , 2006, British journal of anaesthesia.

[8]  C. Pandey,et al.  Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. , 2006, Journal of postgraduate medicine.

[9]  J. Kim,et al.  Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea‐predominant irritable bowel syndrome , 2005, Alimentary pharmacology & therapeutics.

[10]  D. Sessler,et al.  Preoperative Gabapentin Decreases Anxiety and Improves Early Functional Recovery from Knee Surgery , 2005, Anesthesia and analgesia.

[11]  M. Hidalgo,et al.  The Clinical Effect of Small Oral Clonidine Doses on Perioperative Outcomes in Patients Undergoing Abdominal Hysterectomy , 2005, Anesthesia and analgesia.

[12]  M. Türe,et al.  The Analgesic Effects of Gabapentin After Total Abdominal Hysterectomy , 2004, Anesthesia and analgesia.

[13]  H. Flyger,et al.  A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. , 2002, Anesthesiology.

[14]  P. Kam,et al.  Gabapentin: pharmacology and its use in pain management , 2002, Anaesthesia.

[15]  K. Goa,et al.  Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. , 1993, Drugs.

[16]  L. Quintin,et al.  Oxygen uptake after major abdominal surgery: effect of clonidine. , 1991, Anesthesiology.

[17]  L. Quintin,et al.  Anesthesia and Hypertension: The Effect of Clonidine on Perioperative Hemodynamics and Isoflurane Requirements , 1987, Anesthesiology.

[18]  R. Shanks,et al.  Effects of azepexole and clonidine on baroreceptor mediated reflex bradycardia and physiological tremor in man. , 1985, British journal of clinical pharmacology.

[19]  H. Wolff.  Headache and Other Head Pain , 1972 .

[20]  H. Wolff,et al.  HEADACHE AND OTHER HEAD PAIN , 1964 .