Empirical solvation models can be used to differentiate native from near‐native conformations of bovine pancreatic trypsin inhibitor

Several hydration models for peptides and proteins based on solvent accessible surface area have been proposed previously. We have evaluated some of these models as well as four new ones in the context of near‐native conformations of a protein. In addition, we propose an empirical site–site distance‐dependent correction that can be used in conjuction with any of these models.

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