Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway.

[1]  W. Busse,et al.  Type 2 immunity in the skin and lungs , 2020, Allergy.

[2]  T. Tomonaga,et al.  Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice , 2019, Nutrients.

[3]  Z. Tao,et al.  Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps , 2018, European Archives of Oto-Rhino-Laryngology.

[4]  Yuan Zhang,et al.  Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis , 2018, Allergy, asthma & immunology research.

[5]  M. Ishii,et al.  The 17,18‐epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques , 2017, The Journal of allergy and clinical immunology.

[6]  P. Hellings,et al.  Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis , 2017, The Journal of allergy and clinical immunology.

[7]  M. Wickman,et al.  Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease , 2017, The Journal of allergy and clinical immunology.

[8]  Yin Cheng,et al.  ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β1 pathway , 2017, Lipids in Health and Disease.

[9]  Joaquim Mullol,et al.  Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision , 2017, The Journal of allergy and clinical immunology.

[10]  M. Idzko,et al.  Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients , 2017, The Journal of allergy and clinical immunology.

[11]  P. Hellings,et al.  Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease. , 2017, Rhinology.

[12]  S. Durham,et al.  Pathogenesis of rhinitis , 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  K. Chung.  Dupilumab: a potential new treatment for severe asthma , 2016, The Lancet.

[14]  Hyunji Lee,et al.  Decreased Expression of E-cadherin and ZO-1 in the Nasal Mucosa of Patients with Allergic Rhinitis: Altered Regulation of E-cadherin by IL-4, IL-5, and TNF-alpha , 2016, American journal of rhinology & allergy.

[15]  P. Hellings,et al.  Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression. , 2016, The Journal of allergy and clinical immunology.

[16]  E. R. Sutherland,et al.  Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial. , 2016, JAMA.

[17]  R. Reifen,et al.  α-Linolenic acid (ALA) is an anti-inflammatory agent in inflammatory bowel disease. , 2015, The Journal of nutritional biochemistry.

[18]  Makoto Arita,et al.  Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut , 2015, Scientific Reports.

[19]  S. Walsh,et al.  Clinical Practice Guideline , 2015, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[20]  M. Arita,et al.  Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. , 2015, Allergology international : official journal of the Japanese Society of Allergology.

[21]  H. Aukema,et al.  Flaxseed Consumption Reduces Blood Pressure in Patients With Hypertension by Altering Circulating Oxylipins via an &agr;-Linolenic Acid–Induced Inhibition of Soluble Epoxide Hydrolase , 2014, Hypertension.

[22]  A. Nusrat,et al.  Interleukin‐4 and interleukin‐13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression , 2014, International forum of allergy & rhinology.

[23]  R. Flavell,et al.  TH2, allergy and group 2 innate lymphoid cells , 2013, Nature Immunology.

[24]  A. Yu,et al.  Claudins and the modulation of tight junction permeability. , 2013, Physiological reviews.

[25]  S. Georas,et al.  Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells , 2013, Tissue barriers.

[26]  J. Bousquet,et al.  Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? , 2013, Allergy.

[27]  H. Isoda,et al.  α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression , 2013, Cytotechnology.

[28]  C. Akdis,et al.  Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4. , 2012, The Journal of allergy and clinical immunology.

[29]  Jigar H. Shah,et al.  Allergic rhinitis: an update on disease, present treatments and future prospects. , 2011, International immunopharmacology.

[30]  R. Pawankar,et al.  Overview on the pathomechanisms of allergic rhinitis , 2011, Asia Pacific allergy.

[31]  P. Howarth,et al.  Defective epithelial barrier function in asthma. , 2011, The Journal of allergy and clinical immunology.

[32]  H. Schüler,et al.  Comparative Structural Analysis of Lipid Binding START Domains , 2011, PloS one.

[33]  Wei Zhang,et al.  α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. , 2011, Archives of medical research.

[34]  T. Beaty,et al.  Tight junction defects in patients with atopic dermatitis. , 2011, The Journal of allergy and clinical immunology.

[35]  C. Weber,et al.  Tight junction pore and leak pathways: a dynamic duo. , 2011, Annual review of physiology.

[36]  P. Niphadkar,et al.  Role played by Th2 type cytokines in IgE mediated allergy and asthma , 2010, Lung India : official organ of Indian Chest Society.

[37]  Carien M Niessen,et al.  Tight junctions/adherens junctions: basic structure and function. , 2007, The Journal of investigative dermatology.

[38]  E. Rugarli,et al.  A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor , 2006, BMC Biology.

[39]  S. Wootton,et al.  Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women , 2002, British Journal of Nutrition.

[40]  T. Vandenbos,et al.  Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. , 2001, American journal of physiology. Cell physiology.

[41]  W. Busse,et al.  Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. , 2001, The Journal of allergy and clinical immunology.

[42]  S. Colgan,et al.  IL-4 directly modulates function of a model human intestinal epithelium. , 1994, Journal of immunology.