Trauma-induced extracranial internal carotid artery dissection leading to multiple infarcts in a young girl.

Carotid artery dissections (CADs) represent an uncommon clinical condition that should be considered in the differential diagnosis of young individuals presenting with symptoms of stroke. The basic pathological changes in CAD include a disruption in the media or intima of arterial wall, through which the affected vasculature is predisposed to aneurysm or stenosis, and subsequent stroke. Carotid artery dissection may occur spontaneously or result from trauma, an underlying arteriopathic condition, or predisposing risk factors. The heterogeneous clinical presentations of CAD represent significant diagnostic difficulties, which often lead to delays in diagnosis and treatment. Further complicating the clinical picture is the lack of consensus regarding effective treatment modalities. Because of the often-subtle findings present in CAD, the treating physician must have a high index of suspicion to accurately diagnose and manage the condition. We report extracranial internal CAD in a 17-year-old girl leading to multiple infarcts that was successfully managed with initial antiplatelet therapy and subsequent anticoagulation.

[1]  S. Engelter,et al.  Antithrombotic Drugs for Carotid Artery Dissection , 2004 .

[2]  G. Hankey,et al.  Antithrombotic Drugs for Carotid Artery Dissection , 2004, Stroke.

[3]  E. Ringelstein,et al.  Cervical artery dissection—clinical features, risk factors, therapy and outcome in 126 patients , 2003, Journal of Neurology.

[4]  L. Caplan,et al.  Spontaneous intracranial internal carotid artery dissection: report of 10 patients. , 2002, Archives of neurology.

[5]  G. Schroth,et al.  Thrombolysis in patients with acute stroke caused by cervical artery dissection: analysis of 9 patients and review of the literature. , 2002, Archives of neurology.

[6]  T. Brandt,et al.  Spontaneous cervical artery dissection: from risk factors toward pathogenesis. , 2002, Stroke.

[7]  G. Schroth,et al.  Carotid dissection with and without ischemic events , 2001, Neurology.

[8]  A. Grau,et al.  Pathogenesis of cervical artery dissections , 2001, Neurology.

[9]  J. Honnorat,et al.  Intravenous tPA in acute ischemic stroke related to internal carotid artery dissection , 2000, Neurology.

[10]  K. Chang,et al.  Significance of acute multiple brain infarction on diffusion-weighted imaging. , 2000, Stroke.

[11]  P. Cameron,et al.  Cervicocerebral artery dissections. , 1999, Journal of accident & emergency medicine.

[12]  A. Hammers,et al.  Stroke following chiropractic manipulation of the cervical spine , 1999, Journal of Neurology.

[13]  M. Bousser,et al.  Internal carotid artery dissection: an update , 1998, Journal of the Neurological Sciences.

[14]  S. Kasner,et al.  Magnetic resonance angiography demonstrates vascular healing of carotid and vertebral artery dissections. , 1997, Stroke.

[15]  Peter Sandercock,et al.  The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke , 1997, The Lancet.

[16]  B. Mokri,et al.  Cranial nerve palsy in spontaneous dissection of the extracranial internal carotid artery , 1996, Neurology.

[17]  P. Byers,et al.  Cerebrovascular complications in Ehlers‐Danlos syndrome type IV , 1995, Annals of neurology.

[18]  B. Mokri,et al.  Headache and neck pain in spontaneous internal carotid and vertebral artery dissections , 1995, Neurology.

[19]  M. Sturzenegger Spontaneous internal carotid artery dissection: Early diagnosis and management in 44 patients , 1995, Journal of Neurology.

[20]  L. Goldstein,et al.  Stroke due to recurrent ipsilateral carotid artery dissection in a young adult. , 1995, Stroke.

[21]  P. Barnes,et al.  Dissection of the carotid and vertebral arteries: imaging with MR angiography. , 1995, AJR. American journal of roentgenology.

[22]  P. Touboul,et al.  Time course of symptoms in extracranial carotid artery dissections. A series of 80 patients. , 1995, Stroke.

[23]  W. Schievink,et al.  Coexistence of Fibromuscular Dysplasia and Cystic Medial Necrosis in a Patient With Marfan's Syndrome and Bilateral Carotid Artery Dissections , 1994, Stroke.

[24]  M. Giroud,et al.  Incidence of internal carotid artery dissection in the community of Dijon. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[25]  W. Schievink,et al.  Spontaneous dissections of cervicocephalic arteries in childhood and adolescence , 1994, Neurology.

[26]  D. Jenny,et al.  Internal Carotid Artery Redundancy Is Significantly Associated With Dissection , 1994, Stroke.

[27]  W. Schievink,et al.  Neurovascular Manifestations of Heritable Connective Tissue Disorders: A Review , 1994, Stroke.

[28]  W M O'Fallon,et al.  Recurrent spontaneous cervical-artery dissection. , 1994, The New England journal of medicine.

[29]  J. Whisnant,et al.  Internal Carotid Artery Dissection in a Community: Rochester, Minnesota, 1987–1992 , 1993, Stroke.

[30]  J. Bogousslavsky,et al.  Ischemic stroke in patients under age 45. , 1992, Neurologic clinics.

[31]  G. Lanzino,et al.  Etiopathogenesis and prognosis of cerebral ischemia in young adults. , 1991, Acta neurologica Scandinavica.

[32]  F. Lisovoski,et al.  Cerebral infarction in young people. A study of 148 patients with early cerebral angiography. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[33]  R N Bryan,et al.  Diagnosis of Acute Cerebral Infarction : Comparison of CT and MR Imaging 611 , 2013 .

[34]  B. Mokri Traumatic and spontaneous extracranial internal carotid artery dissections , 1990, Journal of Neurology.

[35]  G. Hankey,et al.  Stroke in Young Adults , 2017 .

[36]  P. Ockelford,et al.  Etiology, prognosis, and hemostatic function after cerebral infarction in young adults. , 1989, Stroke.

[37]  B. Mokri,et al.  Traumatic dissections of the extracranial internal carotid artery. , 1988, Journal of neurosurgery.

[38]  C. Zarins,et al.  Spontaneous dissection of the extracranial vertebral arteries. , 1985, Stroke.

[39]  D. Kelly,et al.  Traumatic dissection of the extracranial internal carotid artery. , 1980, Neurosurgery.

[40]  Fisher Cm Transient paralytic attacks of obscure nature: the question of non-convulsive seizure paralysis. , 1978 .

[41]  C. Fisher,et al.  Spontaneous Dissection of Cervico-Cerebral Arteries , 1978, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[42]  J. K. Paterson Neurological complications of cervical spine manipulation. , 2001, Journal of the Royal Society of Medicine.

[43]  G. Schuierer,et al.  Craniocervical artery dissection: MR imaging and MR angiographic findings , 1999, European Radiology.

[44]  V. Servois,et al.  Carotid and vertebral artery dissections: three-dimensional time-of-flight MR angiography and MR imaging versus conventional angiography. , 1994, Radiology.

[45]  P. Bladin,et al.  Mechanisms in cerebral lesions in trauma to high cervical portion of the vertebral artery--rotation injury. , 1975, Proceedings of the Australian Association of Neurologists.