On the spherical prototype of a complex dissipative late-stage formation seen in terms of least action Vojta-Natanson principle

The spherical prototype of a crystalline and/or disorderly formation may help in understanding the final stages of many complex biomolecular arrangements. These stages are important for both naturally organized simple biosystems, such as protein (or, other amphiphilic) aggregates in vivo, as well as certain their artificial counterparts, mimicking either in vitro or in silico their structure-property principal relationship. For our particular one-seed based realization of a protein crystal/aggregate late-stage nucleus grown from nearby fluctuating environment, it turns out that the (osmotic-type) pressure could be, due to local inhomogeneities, and their dynamics shown up in the double layer tightly surrounding the growing object, still an appreciably detectable quantity. This is due to the fact that a special-type generalized thermodynamic (Vojta-Natanson) momentum, subjected to the nucleus' surface, is manifested interchangeably, whereas the total energy of the solution in the double layer could not be such within the stationary regime explored. It is plausible since the double layer width, related to the object's surface, contributes ultimately, while based on the so-defined momentum's changes, to the pressure within this narrow flickering zone, while leaving the total energy fairly unchanged. From the hydrodynamic point of view, the system behaves quite trivially, since the circumventing flow should rather be of laminar, thus not-with-matter supplying, character.

[1]  A. Gadomski Kinetic–thermodynamic effects accompanying model protein-like aggregation: The wave-like limit and beyond it , 2007 .

[2]  R. Rudnicki,et al.  Kinetics of growth process controlled by convective fluctuations. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[3]  Pattern formation and fluctuation-induced transitions in protein crystallization. , 2004, The Journal of chemical physics.

[4]  A. Gadomski Convection-driven growth in fluctuating velocity field , 1993 .

[5]  F. Márkus,et al.  Onsager's regression and the field theory of parabolic transport processes , 2003 .

[6]  W. William Wilson,et al.  Relation between the solubility of proteins in aqueous solutions and the second virial coefficient of the solution , 1999 .

[7]  Michele Vendruscolo,et al.  Theoretical approaches to protein aggregation. , 2006, Protein and peptide letters.

[8]  Are organisms committed to lower their rates of entropy production? Possible relevance to evolution of the Prigogine theorem and the ergodic hypothesis. , 2006, Bio Systems.

[9]  A. Gadomski,et al.  The growing processes in diffusive and convective fields , 1993 .

[10]  Zbigniew J. Grzywna,et al.  NON-MARKOVIAN CHARACTER OF IONIC CURRENT FLUCTUATIONS IN MEMBRANE CHANNELS , 1998 .

[11]  Adam Gadomski,et al.  On the Protein Crystal Formation as an Interface-Controlled Process with Prototype Ion-Channeling Effect , 2007, Journal of biological physics.

[12]  D. Bratko,et al.  Competition between protein folding and aggregation: A three-dimensional lattice-model simulation , 2001 .

[13]  A. Chernov CRYSTALS BUILT OF BIOLOGICAL MACROMOLECULES , 1997 .

[14]  P. Glansdorff,et al.  Non-equilibrium stability theory , 1970 .

[15]  On the elastic contribution to crystal growth in complex environments , 2005 .

[16]  P. Hänggi,et al.  Reaction-rate theory: fifty years after Kramers , 1990 .

[17]  A. Donald,et al.  The mechanism of amyloid spherulite formation by bovine insulin. , 2005, Biophysical journal.

[18]  J. Drenth,et al.  The protein-water phase diagram and the growth of protein crystals from aqueous solution , 1998 .