Silicon nitride films for the protective functional coating: blood compatibility and biomechanical property study.

Behaviors of silicon nitride films and their relation to blood compatibility and biomechanical have been interesting subjects to researchers. A systematic blood compatibility and biomechanical property investigation on the deposition of silicon-nitride films under varying N₂ and CF₄ flows was carried out by direct current unbalanced magnetron sputtering techniques. Significant role of surface property, chemical bonding state of silicon nitride film and blood compatibility, mechanical properties for the films were observed. The chemical bonding configurations, surface topography, contact angle and mechanical properties were characterized by means of X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and nano-indentation technique and CSEM pin-on-disk tribometer. Blood compatibility of the films was evaluated by platelet adhesion investigation. The results of the platelet adhesion tests shown that the effect of fluorine and nitrogen-doped revealed an intimate relationship between the ratio of polar component and dispersion component of the surface energy and its hemocompatibility. Si-N-O coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials. The chemical bonding state made an adjustment in microstructured surfaces, once in the totally wettable configuration, may improve the initial contact between platelet and biomedical materials, due to the appropriate ratio of dispersion component and polar component. To resist wear, biomedical components require coatings that are tough and hard, have low friction, and are bio-inert. The study suggests that by Si-N coating the metal surfaces could be a choice to prolong the life of the sliding pair Co-Cr-Mo alloy/UHMWPE implants.

[1]  N. Huang,et al.  The effects of amorphous carbon films deposited on polyethylene terephthalate on bacterial adhesion. , 2004, Biomaterials.

[2]  I. R. McColl,et al.  Protein adsorption and platelet attachment and activation, on TiN, TiC, and DLC coatings on titanium for cardiovascular applications. , 2000, Journal of biomedical materials research.

[3]  N. Huang,et al.  Effects of negative low substrate bias voltage on the structure and properties of fluorinated amorphous carbon films synthesized by plasma immersion ion implantation and deposition , 2004 .

[4]  S. Adachi,et al.  Chemical treatment effect of Si(111) surfaces in F‐based aqueous solutions , 1996 .

[5]  Platelet activation behavior on nitrogen plasma-implanted silicon , 2007 .

[6]  N. Rushton,et al.  Biocompatibility of diamond-like carbon coating. , 1991, Biomaterials.

[7]  M. Bohner,et al.  Biofilm formation on bone grafts and bone graft substitutes: comparison of different materials by a standard in vitro test and microcalorimetry. , 2010, Acta biomaterialia.

[8]  J. Emmerlich,et al.  Structure and properties of pulsed-laser deposited carbon nitride thin films , 2006 .

[9]  A. Bendavid,et al.  Modification of diamond-like carbon coatings with fluorine to reduce biofouling adhesion , 2010 .

[10]  G. Fenske,et al.  Tribological performance of some alternative bearing materials for artificial joints , 2003 .

[11]  J. Cilley,et al.  Diamond-like carbon coating and plasma or glow discharge treatment of mechanical heart valves. , 1999, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[12]  S. Lau,et al.  Tribological characterisation of diamond-like carbon coatings on Co–Cr–Mo alloy for orthopaedic applications , 2001 .

[13]  A. Hotta,et al.  Fluorine doping into diamond-like carbon coatings inhibits protein adsorption and platelet activation. , 2007, Journal of biomedical materials research. Part A.

[14]  P Descouts,et al.  Haemocompatibility evaluation of DLC- and SiC-coated surfaces. , 2003, European cells & materials.

[15]  Paul K. Chu,et al.  Surface energy, wettability, and blood compatibility phosphorus doped diamond-like carbon films , 2005 .

[16]  O. Odusanya,et al.  Effect of nitrogen plasma-based ion implantation on joint prosthetic material , 2002 .

[17]  J. Runt,et al.  Dynamics of hydrated polyurethane biomaterials: Surface microphase restructuring, protein activity and platelet adhesion. , 2010, Acta biomaterialia.

[18]  L. Rodríguez-Fernández,et al.  Role of hydrogen on the deposition and properties of fluorinated silicon-nitride films prepared by inductively coupled plasma enhanced chemical vapor deposition using SiF4∕N2∕H2 mixtures , 2005 .

[19]  N. Huang,et al.  Activation of platelets adhered on amorphous hydrogenated carbon (a-C:H) films synthesized by plasma immersion ion implantation-deposition (PIII-D). , 2003, Biomaterials.

[20]  P. Campbell,et al.  Cobalt and Chromium Concentrations in Patients With Metal on Metal Total Hip Replacements , 1996, Clinical orthopaedics and related research.

[21]  Y. Weng,et al.  Immobilization of bovine serum albumin on TiO2 film via chemisorption of H3PO4 interface and effects on platelets adhesion , 2007 .

[22]  R. K. Roy,et al.  Biomedical applications of diamond-like carbon coatings: a review. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[23]  Tae Hyun Sung,et al.  Composition, oxidation, and optical properties of fluorinated silicon nitride film by inductively coupled plasma enhanced chemical vapor deposition , 1999 .

[24]  N. Jiang,et al.  Blood compatibilities of carbon nitride film deposited on biomedical NiTi alloy , 2009 .

[25]  E. Broitman,et al.  Thermal stability of carbon nitride thin films , 2001 .

[26]  D. Xiong,et al.  Friction and wear behavior of nitrogen ion implanted UHMWPE against ZrO2 ceramic , 2003 .

[27]  A. Liu,et al.  Prediction of New Low Compressibility Solids , 1989, Science.

[28]  R. Hauert.  A review of modified DLC coatings for biological applications , 2003 .

[29]  C. Kirkpatrick,et al.  Software-supported image quantification of angiogenesis in an in vitro culture system: application to studies of biocompatibility. , 2002, Biomaterials.

[30]  Y. Ikada,et al.  Cell adhesion to plasma-treated polymer surfaces , 1993 .

[31]  B. Tay,et al.  Tribological characterization of surface modified UHMWPE against DLC-coated Co-Cr-Mo , 2005 .

[32]  A. Ogwu,et al.  Platelet adhesion on silicon modified hydrogenated amorphous carbon films. , 2004, Biomaterials.

[33]  J. Chen,et al.  Behavior of cultured human umbilical vein endothelial cells on titanium oxide films fabricated by plasma immersion ion implantation and deposition , 2004 .

[34]  F. A. Kuznetsov,et al.  The investigation of properties of silicon nitride films obtained by RPECVD from hexamethyldisilazane , 1997 .

[35]  V. Tiainen.  Amorphous carbon as a bio-mechanical coating — mechanical properties and biological applications , 2001 .

[36]  H. Thelen,et al.  Glutardialdehyde induced fluorescence technique (GIFT): a new method for the imaging of platelet adhesion on biomaterials. , 2000, Journal of biomedical materials research.

[37]  J. Shin,et al.  Hemocompatibility of surface-modified, silicon-incorporated, diamond-like carbon films. , 2009, Acta biomaterialia.

[38]  G. Pharr,et al.  Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology , 2004 .

[39]  H. Toyoshima,et al.  Electrical properties of silicon nitride films plasma‐deposited from SiF4, N2, and H2 source gases , 1985 .

[40]  T. Saito,et al.  Antithrombogenicity of fluorinated diamond-like carbon films , 2005 .

[41]  A. Loir,et al.  Towards the deposition of tetrahedral diamond-like carbon films on hip joints by femtosecond pulsed laser ablation , 2004 .

[42]  M. Hori,et al.  Ultrathin fluorinated silicon nitride gate dielectric films formed by remote plasma enhanced chemical vapor deposition employing NH3 and SiF4 , 2001 .