The nuclear proteins in the liver of rabbits with an inherited motorial failure

Summary The composition and electrophoretic patterns of nuclear sap and chromatin proteins from the liver of normal and genetically immobilized rabbits were compared. It was found that RNA content and the amount of some nonhistone proteins changed in defective animals. These variations may result from genetic differences between normal rabbits and rabbits with an inborn motorial insufficiency or may appear in consequence of the effect of limb paresis on the liver metabolism. Zusammenfassung Die Kernproteine in der Leber von Kaninchen mit genetischem Bewegungsdefekt Die Zusammensetzung und das elektrophoretische Muster des Kernsaftes und der Kernproteine aus der Leber normaler und genetisch immobilisierter Kaninchen werden verglichen. Es zeigt sich, das der RNS-Gehalt und die Menge einiger Nicht-Histonproteine in defekten Tieren sich geandert hat. Diese Variabilitat kann von genetischen Unterschieden zwischen normalen und Kaninchen mit angeborener Bewegungsinsuffizienz herruhren oder kann eine Folge der Wirkung der Lahmung der Extremitaten auf den Lebermetabolismus darstellen. Resume Les proteines nucleaires dans le foie de lapins avec defaut moteur genetique Les auteurs ont compares la composition et le modele electrophoretique du suc nucleaire et des proteines nucleaires du foie de lapins normaux et genetiquement immobilises. On a observe que la teneur ARN et la quantite de quelques proteines non-histones changeaient dans les animaux defectifs. Ces variabilites peuvent resulter des differences genetiques entre lapins normaux et lapins avec insuffisance motrice congenitale ou peuvent representer la suite de l'effet de paralysie des extremites sur le metabolisme du foie. Resumen Proteinas nucleares en el higado del conejo con defectos geneticos motores Fueron comparadas la composicion y los patrones electroforeticos de proteinas nucleares del fluido y cromatina desde el higado de conejos normales y conejos geneticamente paraliticos. Fue encontrado que el contenido de RNA y la cantidad de algunas proteinas no-histonas, cambian en los animales con el defecto. Esta variabilidad puede resultar de las diferencias geneticas en los conejos normales y conejos con insuficiencia motora al nacimiento o puede aparecer como consecuencia del efecto paralitico en las extremidades debido al metabolismo hepatico.

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