A semiclosed-loop optimal control system for blood glucose level in diabetics

In this manuscript, the well-known Bergman nonlinear mathematical model of the plasma glucose/insulin interaction is adopted and a semi closed-loop optimal technique is proposed for the correction of hyperglycemia in diabetic subjects. Computer simulations are used to evaluate the effectiveness of the proposed technique and to demonstrate its superiority in controlling hyperglycemia over other existing algorithms.

[1]  R. Bergman,et al.  Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. , 1981, The Journal of clinical investigation.

[2]  K. Teo,et al.  Optimal insulin infusion resulting from a mathematical model of blood glucose dynamics , 1989, IEEE Transactions on Biomedical Engineering.

[3]  R. Ollerton.  Application of optimal control theory to diabetes mellitus , 1989 .

[4]  G. Coté,et al.  Glucose monitoring using implanted fluorescent microspheres , 2000, IEEE Engineering in Medicine and Biology Magazine.

[5]  E. Kraegen,et al.  Blood Glucose Control by Intermittent Loop Closure in the Basal Mode: Computer Simulation Studies with a Diabetic Model , 1985, Diabetes Care.

[6]  G V Gill,et al.  Impaired subcutaneous absorption of insulin in 'brittle' diabetics. , 1982, Acta endocrinologica.

[7]  V. Bolie,et al.  Coefficients of normal blood glucose regulation. , 1961, Journal of applied physiology.

[8]  Y. Z. Ider,et al.  Quantitative estimation of insulin sensitivity. , 1979, The American journal of physiology.

[9]  E W Kraegen,et al.  A semi‐closed loop computer‐assisted insulin infusion system , 1984, The Medical journal of Australia.

[10]  S. Genuth,et al.  Control of Hyperglycemia in Adult Diabetics by Pulsed Insulin Delivery , 1977, Diabetes.

[11]  E. Kraegen,et al.  Insulin responses to varying profiles of subcutaneous insulin infusion: kinetic modelling studies , 1984, Diabetologia.

[12]  David B. Troy.  Remington : the science and practice of pharmacy , 2006 .

[13]  E. Kraegen,et al.  Control of blood glucose in diabetics using an artificial pancreas. , 1977, Australian and New Zealand journal of medicine.

[14]  L C Gatewood,et al.  Model studies of blood-glucose regulation. , 1965, The Bulletin of mathematical biophysics.

[15]  M. Fisher,et al.  A semiclosed-loop algorithm for the control of blood glucose levels in diabetics , 1991, IEEE Transactions on Biomedical Engineering.