Surface Engineering in Wearable Sensors for Medical Diagnostic Applications

In a time of rising average population and complex illnesses, the healthcare system is strained and struggling to keep costs low. Wearable devices are a potential solution to detecting the onset of sickness allowing for early treatment as well as continuous monitoring to prevent readmittance. Utilization of sensors to monitor patients will allow them to return to the comfort of their home while still under physician supervision remotely in case treatment is necessary, freeing up hospital space and staff to treat those in need of direct care. Additionally, in the consumer market, wearable devices are utilized by millions of users to monitor their vital signs and general health. In this manuscript, various wearable device, biosensors, and their applications are presented, as well as methods such as surface engineering, a powerful tool to incorporate materials into devices to result in increased functionality. Current challenges and the future outlook of the wearables industry are also discussed.

[1]  D De Rossi,et al.  A Wearable Sensor for Measuring Sweat Rate , 2010, IEEE Sensors Journal.

[2]  Wan-Young Chung,et al.  Wireless sensor network based wearable smart shirt for ubiquitous health and activity monitoring , 2009 .

[3]  Devendra K. Sahu,et al.  Frequency and Temperature Dependence of Dielectric Properties of Pure Poly Vinylidene Fluoride (PVDF) Thin Films , 2010 .

[4]  W. Mittelmeier,et al.  Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology. , 2003, The Journal of antimicrobial chemotherapy.

[5]  D. Schmaljohann Thermo- and pH-responsive polymers in drug delivery. , 2006, Advanced drug delivery reviews.

[6]  David R Bassett,et al.  Calibration and validation of wearable monitors. , 2012, Medicine and science in sports and exercise.

[7]  Yu Bai,et al.  Enhanced dielectric performance of BaTiO3/PVDF composites prepared by modified process for energy storage applications , 2015, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[8]  M. R. Sankar,et al.  Laser cladding with HA and functionally graded TiO2-HA precursors on Ti–6Al–4V alloy for enhancing bioactivity and cyto-compatibility , 2018, Surface and Coatings Technology.

[9]  Joseph Wang,et al.  Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring. , 2014, Biosensors & bioelectronics.

[10]  Anil Mahapatro,et al.  Bio-functional nano-coatings on metallic biomaterials. , 2015, Materials science & engineering. C, Materials for biological applications.

[11]  M. C. Stuart,et al.  Emerging applications of stimuli-responsive polymer materials. , 2010, Nature materials.

[12]  Damià Barceló,et al.  Biosensors for environmental monitoring A global perspective. , 2005, Talanta.

[13]  Pierre Layrolle,et al.  Biomimetic Hydroxyapatite Coating on Metal Implants , 2004 .

[14]  Jessilyn Dunn,et al.  Wearables and the medical revolution. , 2018, Personalized medicine.

[15]  Frank Witte,et al.  Progress and Challenge for Magnesium Alloys as Biomaterials , 2008 .

[16]  Mitsuo Niinomi,et al.  Mechanical properties of biomedical titanium alloys , 1998 .

[17]  Ming Xu,et al.  Waste electrical and electronic equipment (WEEE) recycling for a sustainable resource supply in the electronics industry in China , 2016 .

[18]  Haider Butt,et al.  Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones , 2018, ACS nano.

[19]  Jacob L. Griffith,et al.  Non-Invasive Electromagnetic Skin Patch Sensor to Measure Intracranial Fluid–Volume Shifts , 2018, Sensors.

[20]  Stanley E. Woodard SansEC sensing technology — A new tool for designing space systems and components , 2011, 2011 Aerospace Conference.

[21]  M D Luque de Castro,et al.  Sweat: a sample with limited present applications and promising future in metabolomics. , 2014, Journal of pharmaceutical and biomedical analysis.

[22]  S. Chae,et al.  Carbon nanotubes and graphene towards soft electronics , 2014, Nano Convergence.

[23]  S. Nakano,et al.  Molecular dynamics of poly(N-isopropylacrylamide) in protic and aprotic solvents studied by dielectric relaxation spectroscopy. , 2012, The journal of physical chemistry. B.

[24]  B M Paddle,et al.  Biosensors for chemical and biological agents of defence interest. , 1996, Biosensors & bioelectronics.

[25]  Roc Berenguer,et al.  Full Passive UHF Tag With a Temperature Sensor Suitable for Human Body Temperature Monitoring , 2010, IEEE Transactions on Circuits and Systems II: Express Briefs.

[26]  E. Han,et al.  Electrodeposition of hydroxyapatite coating on AZ91D magnesium alloy for biomaterial application , 2008 .

[27]  Xiaoxi Li,et al.  An amperometric biosensor for the detection of hydrogen peroxide released from human breast cancer cells. , 2013, Biosensors & bioelectronics.

[28]  Huanfen Yao,et al.  A contact lens with embedded sensor for monitoring tear glucose level. , 2011, Biosensors & bioelectronics.

[29]  Forrest M Kievit,et al.  Surface engineering of iron oxide nanoparticles for targeted cancer therapy. , 2011, Accounts of chemical research.

[30]  R. Klitzing,et al.  The dielectric signature of poly(N-isopropylacrylamide) microgels at the volume phase transition: dependence on the crosslinking density , 2013 .

[31]  Derek G Rodeback,et al.  Salivary uric acid as a noninvasive biomarker of metabolic syndrome , 2012, Diabetology & Metabolic Syndrome.

[32]  P. Serruys,et al.  Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients: Insights From the Arterial Revascularization Therapy Study (ARTS) Trial , 2001, Circulation.

[33]  Jacob L. Griffith,et al.  Passive Self Resonant Skin Patch Sensor to Monitor Cardiac Intraventricular Stroke Volume Using Electromagnetic Properties of Blood , 2018, IEEE Journal of Translational Engineering in Health and Medicine.

[34]  Wenzhao Jia,et al.  Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites. , 2014, The Analyst.

[35]  E. Petricoin,et al.  Proteomic analysis of eccrine sweat: implications for the discovery of schizophrenia biomarker proteins. , 2012, Journal of proteome research.

[36]  Donghee Son,et al.  Deformable devices with integrated functional nanomaterials for wearable electronics , 2016, Nano Convergence.

[37]  C. Nan,et al.  Rescaled temperature dependence of dielectric behavior of ferroelectric polymer composites , 2005 .

[38]  P. Serruys,et al.  Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients , 2001 .

[39]  Claire M. Lochner,et al.  Monitoring of Vital Signs with Flexible and Wearable Medical Devices , 2016, Advanced materials.

[40]  Scott M Smith,et al.  Increased core body temperature in astronauts during long-duration space missions , 2017, Scientific Reports.

[41]  Sangjin Park,et al.  Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. , 2008, Angewandte Chemie.

[42]  G. Marrocco,et al.  Epidermal RFID passive sensor for body temperature measurements , 2014, 2014 IEEE RFID Technology and Applications Conference (RFID-TA).

[43]  John Edwards,et al.  Wireless Sensors Relay Medical Insight to Patients and Caregivers [Special Reports] , 2012, IEEE Signal Processing Magazine.

[44]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[45]  Kobra Omidfar,et al.  New analytical applications of gold nanoparticles as label in antibody based sensors. , 2013, Biosensors & bioelectronics.

[46]  E. Chan,et al.  Pulse oximetry: understanding its basic principles facilitates appreciation of its limitations. , 2013, Respiratory medicine.

[47]  B. Sumerlin,et al.  New directions in thermoresponsive polymers. , 2013, Chemical Society reviews.

[48]  Sungmee Park,et al.  Enhancing the quality of life through wearable technology , 2003, IEEE Engineering in Medicine and Biology Magazine.

[49]  C.C.Y. Poon,et al.  A Health-Shirt using e-Textile Materials for the Continuous and Cuffless Monitoring of Arterial Blood Pressure , 2006, 2006 3rd IEEE/EMBS International Summer School on Medical Devices and Biosensors.

[50]  Keith D K Luk,et al.  A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. , 2010, Biomaterials.

[51]  C. Czeisler,et al.  Relationship between alertness, performance, and body temperature in humans. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[52]  M. Meyers,et al.  Biomedical applications of titanium and its alloys , 2008 .

[53]  Amit Kumar,et al.  E-waste: An overview on generation, collection, legislation and recycling practices , 2017 .

[54]  Y. Liu,et al.  In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating. , 2006, Biomaterials.

[55]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[56]  K. T. Varughese,et al.  Dielectric properties of Poly(vinylidene fluoride)/CaCu3Ti4O12 composites , 2010, 1301.4054.

[57]  M. Rubner,et al.  Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[58]  M. Ward,et al.  Thermoresponsive Polymers for Biomedical Applications , 2011 .

[59]  R. Karlsson,et al.  Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. , 1991, Journal of immunological methods.

[60]  J. A. Goode,et al.  Biosensor Regeneration: A Review of Common Techniques and Outcomes. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[61]  N. Verma,et al.  Biosensor Technology for Pesticides—A review , 2015, Applied Biochemistry and Biotechnology.

[62]  Hiroki Ota,et al.  3D Printed "Earable" Smart Devices for Real-Time Detection of Core Body Temperature. , 2017, ACS sensors.

[63]  Takakazu Oka,et al.  Psychogenic fever: how psychological stress affects body temperature in the clinical population , 2015, Temperature.

[64]  Kiyoshi Funatani,et al.  Emerging technology in surface modification of light metals , 2000 .

[65]  F. Perkins,et al.  Infrared tympanic thermometer: evaluation of a new clinical thermometer. , 1988, Critical care medicine.

[66]  C. Feng,et al.  Preparation and Dielectric Properties of Cu/PVDF Composite Films , 2014 .

[67]  Wu Nanjian,et al.  A novel ultra low power temperature sensor for UHF RFID tag chip , 2007, 2007 IEEE Asian Solid-State Circuits Conference.

[68]  K. Ishihara Novel Polymeric Materials for Obtaining Blood-compatible Surfaces , 1997 .

[69]  L. C. Clark,et al.  ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY , 1962 .

[70]  E. V. D. Heide,et al.  Leading edge erosion of coated wind turbine blades: Review of coating life models , 2015 .

[71]  Meenakshi Choudhary,et al.  Molecular Functionalization of Carbon Nanomaterials for Immuno-diagnosis of Cancer , 2016 .

[72]  Kiyun Han,et al.  Passive Wearable Skin Patch Sensor Measures Limb Hemodynamics Based on Electromagnetic Resonance , 2018, IEEE Transactions on Biomedical Engineering.

[73]  Hiroyuki Kudo,et al.  A flexible and wearable glucose sensor based on functional polymers with soft-MEMS techniques. , 2006, Biosensors & bioelectronics.

[74]  M. R. Sankar,et al.  Mechano-tribological properties and in vitro bioactivity of biphasic calcium phosphate coating on Ti-6Al-4V. , 2018, Journal of the mechanical behavior of biomedical materials.

[75]  Sungmee Park,et al.  Smart Textiles: Wearable Electronic Systems , 2003 .

[76]  W. Keatinge,et al.  Impaired memory registration and speed of reasoning caused by low body temperature , 1983 .

[77]  S. Lai,et al.  Design of a Self-Regulated Drug Delivery Device , 2001 .

[78]  S. Sershen,et al.  Corrigendum to: “Implantable, polymeric systems for modulated drug delivery” , 2003 .

[79]  Elena Ermilova,et al.  Dynamics of linear poly(N-isopropylacrylamide) in water around the phase transition investigated by dielectric relaxation spectroscopy. , 2014, The journal of physical chemistry. B.

[80]  Jens Eickhoff,et al.  A new method of sweat testing: the CF Quantum®sweat test. , 2014, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

[81]  Joseph R. Davis Surface Hardening of Steels: Understanding the Basics , 2003 .

[82]  Ramzy Kahhat,et al.  Best of two worlds? Towards ethical electronics repair, reuse, repurposing and recycling , 2017 .

[83]  F. Wang,et al.  Dielectric Properties of CCTO/PVDF Composite Films , 2013 .

[84]  I. Tothill Biosensors for cancer markers diagnosis. , 2009, Seminars in cell & developmental biology.

[85]  K. Sen,et al.  Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications , 2015 .

[86]  Do Kyung Kim,et al.  Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging. , 2006, Journal of the American Chemical Society.

[87]  Hui Yan,et al.  Improving Dielectric Properties of PVDF Composites by Employing Surface Modified Strong Polarized BaTiO₃ Particles Derived by Molten Salt Method. , 2015, ACS applied materials & interfaces.

[88]  Guang-Zhong Yang,et al.  A wearable multisensing patch for continuous sweat monitoring. , 2017, Biosensors & bioelectronics.

[89]  N P Haas,et al.  Biodegradable poly(D,L-lactide) coating of implants for continuous release of growth factors. , 2001, Journal of biomedical materials research.

[90]  S. Moebus,et al.  Impact of time since last caloric intake on blood glucose levels , 2011, European Journal of Epidemiology.

[91]  Zenton Goh,et al.  Evaluation of the Cadi ThermoSENSOR Wireless Skin-Contact Thermometer Against Ear and Axillary Temperatures in Children☆☆☆ , 2010, Journal of Pediatric Nursing.

[92]  G. Voskerician,et al.  Foreign Body Reaction , 2006, Definitions.

[93]  Nathan Kohler,et al.  Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. , 2002, Biomaterials.

[94]  S. Sershen,et al.  Implantable, polymeric systems for modulated drug delivery. , 2002, Advanced drug delivery reviews.

[95]  David Blaauw,et al.  An ultra low power 1V, 220nW temperature sensor for passive wireless applications , 2008, 2008 IEEE Custom Integrated Circuits Conference.

[96]  Apinunt Thanachayanont,et al.  Self-powered wireless temperature sensors exploit RFID technology , 2006, IEEE Pervasive Computing.

[97]  W. Cheshire Thermoregulatory disorders and illness related to heat and cold stress , 2016, Autonomic Neuroscience.

[98]  K. Shakesheff,et al.  Polymeric systems for controlled drug release. , 1999, Chemical reviews.

[99]  Zhen Cheng,et al.  Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. , 2010, ACS nano.

[100]  M. Wilhelm,et al.  Comparison of Blood and Saliva Lactate Level after Maximum Intensity Exercise , 2012, Acta biologica Hungarica.

[101]  Amy J Wagoner Johnson,et al.  The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. , 2007, Biomaterials.

[102]  Jingjing Wei,et al.  Dielectric relaxations of poly(N-isopropylacrylamide) microgels near the volume phase transition temperature: impact of cross-linking density distribution on the volume phase transition. , 2014, Soft matter.

[103]  K. Andersson,et al.  Development of a rapid low cost fluorescent biosensor for the detection of food contaminants. , 2013, Biosensors & bioelectronics.

[104]  D. Williams,et al.  The corrosion behaviour of Ti-6Al-4V, Ti-6Al-7Nb and Ti-13Nb-13Zr in protein solutions. , 1999, Biomaterials.

[105]  Jeffrey T La Belle,et al.  Self-monitoring of tear glucose: the development of a tear based glucose sensor as an alternative to self-monitoring of blood glucose. , 2016, Chemical communications.

[106]  R Weissleder,et al.  Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties , 1993, Magnetic resonance in medicine.