In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.

[1]  M. V. Heiden,et al.  Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[2]  S. McMahon,et al.  Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro , 1999, The European journal of neuroscience.

[3]  J. Sprent,et al.  The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. , 1999, Immunity.

[4]  M. Bevan,et al.  Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. , 1999, Immunity.

[5]  K. Bottomly,et al.  Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. , 1999, Journal of immunology.

[6]  M. V. Heiden,et al.  Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. , 1999, Molecular cell.

[7]  I. Conlon,et al.  Size Control in Animal Development , 1999, Cell.

[8]  Y. Goltsev,et al.  Tumor necrosis factor receptor and Fas signaling mechanisms. , 1999, Annual review of immunology.

[9]  W. Alexander,et al.  Hemopoietic growth factor receptor abnormalities in leukemia. , 1998, Leukemia research.

[10]  P. Marrack,et al.  T‐cell survival , 1998, Immunological reviews.

[11]  T. P. Neufeld,et al.  Coordination of Growth and Cell Division in the Drosophila Wing , 1998, Cell.

[12]  D. Nesic,et al.  MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. , 1998, Journal of immunology.

[13]  J. Downward.  Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.

[14]  C. Bishop,et al.  Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[15]  L. Cantley,et al.  Phosphoinositide kinases. , 1998, Annual review of biochemistry.

[16]  T. Brocker.  Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells , 1997, The Journal of experimental medicine.

[17]  D. Baltimore,et al.  Interleukin 3-dependent survival by the Akt protein kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[18]  B. Hemmings,et al.  Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B , 1997, European journal of immunology.

[19]  A. Strasser,et al.  The anti‐apoptosis function of Bcl‐2 can be genetically separated from its inhibitory effect on cell cycle entry , 1997, The EMBO journal.

[20]  F. Lemonnier,et al.  Differential requirements for survival and proliferation of CD8 naïve or memory T cells. , 1997, Science.

[21]  M. Deshmukh,et al.  Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. , 1997, Molecular pharmacology.

[22]  F. Shibasaki,et al.  Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 , 1997, Nature.

[23]  G. Linette,et al.  Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  H. Arakawa,et al.  MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. , 1996, Immunity.

[25]  S. Korsmeyer,et al.  Molecular thanatopsis: a discourse on the BCL2 family and cell death. , 1996, Blood.

[26]  M. Raff,et al.  Constitutive expression of the machinery for programmed cell death , 1996, The Journal of cell biology.

[27]  A. Abbas,et al.  The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. , 1996, Immunity.

[28]  F. Finkelman,et al.  bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice , 1996, The Journal of experimental medicine.

[29]  G. Linette,et al.  Bcl-XL and Bcl-2 repress a common pathway of cell death , 1995, The Journal of experimental medicine.

[30]  A. August,et al.  CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. , 1994, International immunology.

[31]  D. Lindholm,et al.  Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3 , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[32]  T. Deckwerth,et al.  Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor , 1993, The Journal of cell biology.

[33]  C. Thompson,et al.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death , 1993, Cell.

[34]  C. Deutsch,et al.  Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes , 1993, Magnetic resonance in medicine.

[35]  S. Tonegawa,et al.  TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells , 1992, Cell.

[36]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[37]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[38]  S. Ward,et al.  Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens , 1992, European journal of immunology.

[39]  R. Schreiber,et al.  Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death , 1990, Nature.

[40]  S. Korsmeyer,et al.  Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. , 1990, Journal of immunology.

[41]  J. Torday,et al.  Coordination of growth and differentiation in the fetal lung. , 1990, Experimental cell research.

[42]  Dale Purves,et al.  Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system , 1988, Nature.

[43]  H. Boehmer,et al.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.

[44]  T. Dexter,et al.  Effect of haematopoietic cell growth factor on intracellular ATP levels , 1983, Nature.

[45]  F. Finkelman,et al.  A method for size separation of murine spleen cells using counterflow centrifugation. , 1983, Journal of immunological methods.