HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53

[1]  M. Buendia,et al.  The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver , 2002, Oncogene.

[2]  Y. Dong,et al.  Overexpression of cyclin E and cyclin-dependent kinase 2 is correlated with development of hepatocellular carcinomas. , 2001, Hepatology research : the official journal of the Japan Society of Hepatology.

[3]  X. Wang,et al.  Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis , 2001, Oncogene.

[4]  J. Diao,et al.  X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. , 2001, Cytokine & growth factor reviews.

[5]  D. Krause,et al.  Transient Activation of Jun N-terminal Kinases and Protection from Apoptosis by the Insulin-like Growth Factor I Receptor Can Be Suppressed by Dicumarol* , 2001, The Journal of Biological Chemistry.

[6]  A. Graessmann,et al.  The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect , 2001, Oncogene.

[7]  J. Jang,et al.  Cyclin D1 overexpression in hepatocellular carcinoma. , 2001, Liver.

[8]  F. Su,et al.  Role of NF-κB and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein , 2001, Journal of Virology.

[9]  B. Slagle,et al.  Expression of Hepatitis B Virus X Protein Does Not Alter the Accumulation of Spontaneous Mutations in Transgenic Mice , 2000, Journal of Virology.

[10]  W. Muller,et al.  Mammary gland neoplasia: insights from transgenic mouse models , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[11]  A. Capovilla,et al.  Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen‐activated protein kinase and JAK/STAT pathways , 2000, Journal of gastroenterology and hepatology.

[12]  S. Murakami.  Hepatitis B Virus X Protein: Structure, Function and Biology , 1999, Intervirology.

[13]  H. Sirma,et al.  Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx , 1999, Oncogene.

[14]  A. Graessmann,et al.  The Hepatitis B Virus HBx Protein Inhibits Caspase 3 Activity* , 1998, The Journal of Biological Chemistry.

[15]  M. Buendia,et al.  p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro , 1998, Oncogene.

[16]  M. Buendia,et al.  Pro-apoptotic effect of the hepatitis B virus X gene. , 1998, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[17]  A. Graessmann,et al.  SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors , 1998, Oncogene.

[18]  Y. Yun,et al.  X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells* , 1998, The Journal of Biological Chemistry.

[19]  B. Slagle,et al.  Hepatitis B Virus X Protein Interferes with Cellular DNA Repair , 1998, Journal of Virology.

[20]  C. Harris,et al.  Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[21]  F. Su,et al.  Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  G. Natoli,et al.  The hepatitis B virus X gene induces p53-mediated programmed cell death. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Buendia,et al.  The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice , 1997, Oncogene.

[24]  N. Jayasuryan,et al.  A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[25]  B. Slagle,et al.  Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene , 1996, Molecular carcinogenesis.

[26]  I. Bièche,et al.  Genetic alterations in breast cancer , 1995, Genes, chromosomes & cancer.

[27]  S. Ullrich,et al.  Functional inactivation but not structural mutation of p53 causes liver cancer , 1995, Nature Genetics.

[28]  R. Schneider,et al.  Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Eithne Costello,et al.  Overexpression of Mos, Ras, Src, and Fos inhibits mouse mammary epithelial cell differentiation , 1992, Molecular and cellular biology.

[30]  L. Donehower,et al.  Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.

[31]  T. Dragani,et al.  Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis. , 1990, Carcinogenesis.

[32]  H. Varmus,et al.  The molecular biology of the hepatitis B viruses. , 1987, Annual review of biochemistry.

[33]  J. Chirgwin,et al.  Isolation of RNA using guanidinium salts. , 1987, Methods in enzymology.

[34]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[35]  A. Graessmann,et al.  [30] Microinjection of tissue culture cells , 1983 .

[36]  Lu-Yu Hwang,et al.  HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS A Prospective Study of 22 707 Men in Taiwan , 1981, The Lancet.

[37]  Y. Gluzman.  SV40-transformed simian cells support the replication of early SV40 mutants , 1981, Cell.