The sensitive period in the development of the trigeminal system of the neonatal rat

In previous studies we have described vibrissae‐related segmentation in the brainstem, thalamus, and cortex of the neonatal rat. Using succinic dehydrogenase (SDH) histochemistry, we delineated the time course in development of the normal segmentation at each level of the trigeminal system and the aberrant segmentation resulting from follicle damage at birth (Killackey and Belford, '79; Belford and Killackey, '79a, b). The present study examines the aberrant patterns that result from damage to the vibrissae follicles at different ages, comparing the patterns at the different levels of the trigeminal system.

[1]  H. Killackey,et al.  Anatomical correlates of the forelimb in the ventrobasal complex and the cuneate nucleus of the neonatal rat , 1978, Brain Research.

[2]  T. Woolsey,et al.  Somatosensory Cortex: Structural Alterations following Early Injury to Sense Organs , 1973, Science.

[3]  T. Woolsey,et al.  Comparative anatomical studies of the Sml face cortex with special reference to the occurrence of “barrels” in layer IV , 1975, The Journal of comparative neurology.

[4]  T A Woolsey,et al.  Effects of early vibrissae damage on neurons in the ventrobasal (VB) thalamus of the mouse , 1979, The Journal of comparative neurology.

[5]  H. van der Loos,et al.  Development of the barrels and barrel field in the somatosensory cortex of the mouse , 1977, The Journal of comparative neurology.

[6]  R L Smith,et al.  The ascending fiber projections from the principal sensory trigeminal nucleus in the rat , 1973, The Journal of comparative neurology.

[7]  T. Woolsey,et al.  Areal changes in mouse cortical barrels following vibrissal damage at different postnatal ages , 1976, The Journal of comparative neurology.

[8]  H. Loos,et al.  Does the skin tell the somatosensory cortex how to construct a map of the periphery? , 1978, Neuroscience Letters.

[9]  H. Killackey,et al.  Central correlates of peripheral pattern alterations in the trigeminal system of the rat , 1980, Brain Research.

[10]  M. Gerard.  AFFERENT IMPULSES OF THE TRIGEMINAL NERVE: THE INTRAMEDULLARY COURSE OF THE PAINFUL, THERMAL AND TACTILE IMPULSES , 1923 .

[11]  W. F. Windle.  Non‐bifurcating nerve fibers of the trigeminal nerve , 1926 .

[12]  H. Killackey,et al.  Anomalous organization of thalamocortical projections consequent to vibrissae removal in the newborn rat and mouse , 1976, Brain Research.

[13]  J. Johnson,et al.  Barrels in cerebral cortex altered by receptor disruption in newborn, but not in five-day-old mice (Cricetidae and Muridae) , 1975, Brain Research.

[14]  R. Lund,et al.  Thalamic afferents from the spinal cord and trigeminal nuclei. An experimental anatomical study in the rat. , 1967, The Journal of comparative neurology.

[15]  D. Jeanmonod,et al.  Mouse somatosensory cortex: Development of the alterations in the barrel field which are caused by injury to the vibrissal follicles , 1977, Neuroscience Letters.

[16]  H. Killackey,et al.  The development of vibrissae representation in subcortical trigeminal centers of the neonatal rat , 1979, The Journal of comparative neurology.

[17]  B. Cragg,et al.  The effect of destroying the whisker follicles in mice on the sensory nerve, the thalamocortical radiation and cortical barrel development , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[18]  H. Killackey,et al.  Vibrissae representation in subcortical trigeminal centers of the neonatal rat , 1979, The Journal of comparative neurology.

[19]  R W Guillery,et al.  Experiments to determine whether retinogeniculate axons can form translaminar collateral sprouts in the dorsal lateral geniculate nucleus of the cat , 1972, The Journal of comparative neurology.

[20]  K. Åström.  On the Central Course of Afferent Fibres in the Trigeminal, Facial, Glossopharyngeal, and Vagal Nerves and their Nuclei in the Mouse. , 1953 .

[22]  H. Killackey,et al.  The formation of afferent patterns in the somatosensory cortex of the neonatal rat , 1979, The Journal of comparative neurology.