Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay.

Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.

[1]  J. Rhim,et al.  Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene , 1983, Nature.

[2]  R. Muschel,et al.  Retraction of data on the human c-ras1H oncogene. , 1983, Science.

[3]  R. Muschel,et al.  The human c-ras1H oncogene: a mutation in normal and neoplastic tissue from the same patient. , 1983, Science.

[4]  L. Kopelovich,et al.  The use of a tumor promoter for the detection of individuals with the gardner syndrome , 1983, Cancer.

[5]  L. Hood,et al.  Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. , 1982, Science.

[6]  Kenji Shimizu,et al.  Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change , 1982, Nature.

[7]  D. Givol,et al.  Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element , 1982, Nature.

[8]  M. Barbacid,et al.  Oncogenes in solid human tumours , 1982, Nature.

[9]  M. Cole,et al.  Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas , 1982, Cell.

[10]  Eugenio Santos,et al.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene , 1982, Nature.

[11]  Cori Bargmann,et al.  Mechanism of activation of a human oncogene , 1982, Nature.

[12]  P. D’Eustachio,et al.  DNA sequence associated with chromosome translocations in mouse plasmacytomas. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[13]  R. Gallo,et al.  onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient , 1982, Nature.

[14]  M. Groudine,et al.  Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line , 1982, Nature.

[15]  E. Scolnick,et al.  Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family , 1982, Journal of virology.

[16]  R. Weinberg,et al.  Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene , 1982, Nature.

[17]  M. Wigler,et al.  Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells , 1982, Nature.

[18]  M. Wigler,et al.  Human-tumor-derived cell lines contain common and different transforming genes , 1981, Cell.

[19]  R. Weinberg,et al.  Three different human tumor cell lines contain different oncogenes , 1981, Cell.

[20]  Richard Axel,et al.  Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells , 1977, Cell.

[21]  L. Kopelovich,et al.  Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus , 1977, Cell.

[22]  J. Fogh,et al.  Absence of HeLa cell contamination in 169 cell lines derived from human tumors. , 1977, Journal of the National Cancer Institute.

[23]  S. Aaronson,et al.  In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. , 1973, Journal of the National Cancer Institute.

[24]  A. van der Eb,et al.  A new technique for the assay of infectivity of human adenovirus 5 DNA. , 1973, Virology.

[25]  J. Fraumeni,et al.  Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. , 1969 .

[26]  J. H. McCutchan,et al.  Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. , 1968, Journal of the National Cancer Institute.

[27]  S. Gartler,et al.  Glucose-6-phosphate dehydrogenase mosaicism as a tracer in the study of hereditary multiple trichoepithelioma. , 1966, American journal of human genetics.

[28]  A. Bernstein,et al.  RNA tumor viruses , 1982 .

[29]  R. W. Miller.  Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960-67. , 1971, Journal of the National Cancer Institute.