Cyclooxygenase-2 and Gastric Cancer

[1]  C. Haglund,et al.  Inhibition of cyclooxygenase‐2 causes regression of gastric adenomas in trefoil factor 1 deficient mice , 2012, International journal of cancer.

[2]  T. Ishikawa,et al.  Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis , 2011, Cancer science.

[3]  J. Califano,et al.  Enforced Expression of miR-101 Inhibits Prostate Cancer Cell Growth by Modulating the COX-2 Pathway In Vivo , 2011, Cancer Prevention Research.

[4]  T. Ishikawa,et al.  Prostaglandin E₂ signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. , 2011, Gastroenterology.

[5]  D. Fan,et al.  The function and mechanism of COX-2 in angiogenesis of gastric cancer cells , 2011, Journal of experimental & clinical cancer research : CR.

[6]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[7]  Jun Yu,et al.  MicroRNA dysregulation in gastric cancer: a new player enters the game , 2010, Oncogene.

[8]  H. Ruan,et al.  MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. , 2010, European journal of cancer.

[9]  Wenjing Tian,et al.  Meta-analysis on the relationship between nonsteroidal anti-inflammatory drug use and gastric cancer , 2010, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[10]  R. DuBois,et al.  Eicosanoids and cancer , 2010, Nature Reviews Cancer.

[11]  Dakang Xu,et al.  Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. , 2010, Clinical immunology.

[12]  R. Schilsky,et al.  Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward , 2010, Clinical Cancer Research.

[13]  T. Sawada,et al.  Reduction of 15‐hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma , 2010, Cancer science.

[14]  H. Kotani,et al.  Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer , 2009, BMC Genomics.

[15]  M. Oshima,et al.  Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models , 2009, Cancer science.

[16]  T. Brzozowski,et al.  Helicobacter pylori infection in gastric cancerogenesis. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[17]  O. Monni,et al.  15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer , 2009, Clinical Cancer Research.

[18]  M. Kuo,et al.  The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. , 2009, Cancer research.

[19]  Ming-Wei Wang,et al.  Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions. , 2009, World journal of gastroenterology.

[20]  R. Liu,et al.  Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cells. , 2009, Cancer letters.

[21]  E. Spisni,et al.  MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. , 2009, Experimental cell research.

[22]  M. Taketo,et al.  Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling. , 2009, Cancer research.

[23]  A. Zauber,et al.  Five-Year Efficacy and Safety Analysis of the Adenoma Prevention with Celecoxib Trial , 2009, Cancer Prevention Research.

[24]  L. Marnett.  The COXIB experience: a look in the rearview mirror. , 2009, Annual review of pharmacology and toxicology.

[25]  Heather R. Roberts,et al.  The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. , 2009, Carcinogenesis.

[26]  C. Abnet,et al.  Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis , 2009, British Journal of Cancer.

[27]  M. Kubo,et al.  Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence: the Hisayama Study. , 2008, American journal of epidemiology.

[28]  T. Tsukamoto,et al.  Roles of cyclooxygenase‐2 and microsomal prostaglandin E synthase‐1 expression and β‐catenin activation in gastric carcinogenesis in N‐methyl‐N‐nitrosourea‐treated K19‐C2mE transgenic mice , 2008, Cancer science.

[29]  W. Leung,et al.  Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. , 2008, Carcinogenesis.

[30]  B. Wong,et al.  Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention. , 2008, World journal of gastroenterology.

[31]  Shuang-yin Han,et al.  Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. , 2008, Carcinogenesis.

[32]  Y. Matsuzaki,et al.  The Effects of Cyclooxygenase2–ProstaglandinE2 Pathway on Helicobacter pylori‐Induced Urokinase‐Type Plasminogen Activator System in the Gastric Cancer Cells , 2008, Helicobacter.

[33]  Timothy C Wang,et al.  Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. , 2008, Gastroenterology.

[34]  Alessandra Renieri,et al.  Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis , 2007, Journal of cellular physiology.

[35]  T. Sawada,et al.  A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. , 2006, Cancer letters.

[36]  H. Tai,et al.  Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. , 2006, Carcinogenesis.

[37]  T. Tsukamoto,et al.  Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. , 2006, Gastroenterology.

[38]  F. Chan,et al.  Effects of Long-term Rofecoxib on Gastric Intestinal Metaplasia: Results of a Randomized Controlled Trial , 2006, Clinical Cancer Research.

[39]  Jing Wu,et al.  Influences of Helicobacter pylori on cyclooxygenase‐2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro , 2006, Journal of gastroenterology and hepatology.

[40]  H. Seno,et al.  Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[41]  C. Haglund,et al.  Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3β in Gastric Cancer Cells* , 2006, Journal of Biological Chemistry.

[42]  C. Haglund,et al.  Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer , 2006, Journal of Clinical Pathology.

[43]  Jaw-Town Lin,et al.  Helicobacter pylori-Induced Invasion and Angiogenesis of Gastric Cells Is Mediated by Cyclooxygenase-2 Induction through TLR2/TLR9 and Promoter Regulation1 , 2005, The Journal of Immunology.

[44]  S. Nordling,et al.  Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR , 2005, Clinical Cancer Research.

[45]  M. Taketo,et al.  Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice. , 2005, Cancer research.

[46]  Jun Yu,et al.  Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants. , 2005, Cancer letters.

[47]  J. Tong,et al.  PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. , 2005, Experimental oncology.

[48]  Robert Riddell,et al.  Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. , 2005, The New England journal of medicine.

[49]  Marc A Pfeffer,et al.  Cardiovascular Risk Associated With Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention , 2005, The New England journal of medicine.

[50]  Andreas Hoeft,et al.  Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. , 2005, The New England journal of medicine.

[51]  J. Lutterbaugh,et al.  15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Jaw-Town Lin,et al.  Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-κB Activation , 2004, Molecular Pharmacology.

[53]  K. Hahm,et al.  The Selective Cyclooxygenase-2 Inhibitor Nimesulide Prevents Helicobacter pylori-Associated Gastric Cancer Development in a Mouse Model , 2004, Clinical Cancer Research.

[54]  K. Takaori,et al.  Concomitant Overexpression of Cyclooxygenase-2 in HER-2–Positive on Smad4-Reduced Human Gastric Carcinomas Is Associated with a Poor Patient Outcome , 2004, Clinical Cancer Research.

[55]  Derrick J. Rossi,et al.  Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. , 2004, Gastroenterology.

[56]  Hiroko Oshima,et al.  Hyperplastic gastric tumors induced by activated macrophages in COX‐2/mPGES‐1 transgenic mice , 2004, The EMBO journal.

[57]  Y. Sugisaki,et al.  Cyclooxygenase-2 expression correlates with angiogenesis and apoptosis in gastric cancer tissue. , 2004, Human pathology.

[58]  C. Haglund,et al.  Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. , 2003, Cancer research.

[59]  F. Gao,et al.  Helicobacter pylori stimulates host cyclooxygenase‐2 gene transcription: critical importance of MEK/ERK‐dependent activation of USF1/‐2 and CREB transcription factors , 2003, Cellular microbiology.

[60]  C. Buskens,et al.  Cyclooxygenase‐2 and gastric carcinogenesis , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[61]  Jianming Xu,et al.  Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. , 2003, World journal of gastroenterology.

[62]  Y. Seo,et al.  Cyclooxygenase-2 Overexpression Correlates With Vascular Endothelial Growth Factor Expression and Tumor Angiogenesis in Gastric Cancer , 2003, Journal of clinical gastroenterology.

[63]  A. Ristimäki,et al.  Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. , 2003, Cancer research.

[64]  F. Schmitz,et al.  Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. , 2003, Cancer letters.

[65]  Y. Joo,et al.  Cyclooxygenase-2 Expression Is Associated with Well-Differentiated and Intestinal-Type Pathways in Gastric Carcinogenesis , 2003, Digestion.

[66]  Yuan Yuan,et al.  Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. , 2003, World journal of gastroenterology.

[67]  C. Buskens,et al.  Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. , 2002, Gastroenterology.

[68]  A. Ristimäki,et al.  Cyclooxygenase‐2 expression during carcinogenesis in the human stomach , 2002, The Journal of pathology.

[69]  J. Isola,et al.  Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. , 2002, Cancer research.

[70]  S. Moochhala,et al.  Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. , 2001, Cancer letters.

[71]  C. Chi,et al.  Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. , 2001, Medical hypotheses.

[72]  F. Chan,et al.  Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer. , 2001, Cancer letters.

[73]  A. Ristimäki,et al.  Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[74]  L. Hansson,et al.  Aspirin and risk for gastric cancer: a population-based case–control study in Sweden , 2001, British Journal of Cancer.

[75]  F. Chan,et al.  Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer , 2001, British Journal of Cancer.

[76]  J. A. Steitz,et al.  HuR and mRNA stability , 2001, Cellular and Molecular Life Sciences CMLS.

[77]  H. Yokozaki,et al.  Molecular characteristics of eight gastric cancer cell lines established in Japan , 2000, Pathology international.

[78]  F. Chan,et al.  Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. , 2000, The American journal of pathology.

[79]  R. Lancashire,et al.  Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database , 2000, BMJ : British Medical Journal.

[80]  H. S. Kim,et al.  Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[81]  K. Sheahan,et al.  The relationship between cyclooxygenase-2 expression and colorectal cancer. , 1999, JAMA.

[82]  H. Yamamoto,et al.  Overexpression of cyclooxygenase‐2 protein is less frequent in gastric cancers with microsatellite instability , 1999, International journal of cancer.

[83]  D. Zaridze,et al.  Aspirin protects against gastric cancer: Results of a case‐control study from Moscow, Russia , 1999, International journal of cancer.

[84]  H. Shiozaki,et al.  Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma , 1999, American Journal of Gastroenterology.

[85]  A. Ristimäki,et al.  Expression of cyclooxygenase-2 in human gastric carcinoma. , 1997, Cancer research.

[86]  P. Chambon,et al.  Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein , 1996, Science.

[87]  A. Neugut,et al.  Epidemiology of gastric cancer. , 2006, World journal of gastroenterology.

[88]  R. Everson,et al.  Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study , 1994, Epidemiology.

[89]  M. Thun,et al.  Aspirin use and risk of fatal cancer. , 1993, Cancer research.

[90]  T. Hla,et al.  Human cyclooxygenase-2 cDNA. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[91]  J. Ajani,et al.  Molecular epidemiology of genetic susceptibility to gastric cancer: focus on single nucleotide polymorphisms in gastric carcinogenesis. , 2009, American journal of translational research.

[92]  S. Nordling,et al.  COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer , 2009, Tumor Biology.

[93]  R. Chin,et al.  Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis,and inhibits the proliferation of human gastric cancer cells in vitro , 2008 .

[94]  Ho-Jun Song.  Car cinogenesis in Mouse Stomach by Simultaneous Activation of the Wnt Signaling and Prostaglandin $E_2$ Pathway. , 2007 .

[95]  C. Haglund,et al.  Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. , 2006, The Journal of biological chemistry.

[96]  Hong-XiaLi,et al.  Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma , 2003 .

[97]  C. Chi,et al.  Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. , 2001, Medical hypotheses.

[98]  H. Kim,et al.  Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. , 2001, Laboratory investigation; a journal of technical methods and pathology.