Tumour break load is a biologically relevant feature of genomic instability with prognostic value in colorectal cancer.

[1]  J. Ptak,et al.  Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. , 2022, The New England journal of medicine.

[2]  A. Hoischen,et al.  Clinical validation of Whole Genome Sequencing for cancer diagnostics. , 2021, The Journal of molecular diagnostics : JMD.

[3]  N. Schultz,et al.  The genomic landscape of carcinomas with mucinous differentiation , 2021, Scientific Reports.

[4]  C. Andersen,et al.  Circulating tumor DNA analysis for assessment of recurrence risk, benefit of adjuvant therapy, and early relapse detection after treatment in colorectal cancer patients. , 2021 .

[5]  P. Gibbs,et al.  Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. , 2020, The New England journal of medicine.

[6]  A. Lamarca,et al.  Impact of high tumor mutational burden in solid tumors and challenges for biomarker application. , 2020, Cancer treatment reviews.

[7]  Yoshiyuki Watanabe,et al.  Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach , 2020, Archives of Toxicology.

[8]  Jane M. Young,et al.  Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies , 2020, BMC Medicine.

[9]  S. Haan,et al.  Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges , 2020, Cancers.

[10]  N. Wolmark,et al.  Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

[11]  K. Fitzgerald,et al.  DNA sensing by the cGAS–STING pathway in health and disease , 2019, Nature Reviews Genetics.

[12]  N. Stoecklein,et al.  Circulating biomarkers for early detection and clinical management of colorectal cancer. , 2019, Molecular aspects of medicine.

[13]  M. Ebert,et al.  Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy , 2018, Nature Communications.

[14]  L. Cantley,et al.  The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment , 2018, Cell.

[15]  M. Burkard,et al.  MACROD2, an Original Cause of CIN? , 2018, Cancer Discovery.

[16]  Adrian V. Lee,et al.  An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics , 2018, Cell.

[17]  Steven J. M. Jones,et al.  Oncogenic Signaling Pathways in The Cancer Genome Atlas. , 2018, Cell.

[18]  C. Swanton,et al.  Determinants and clinical implications of chromosomal instability in cancer , 2018, Nature Reviews Clinical Oncology.

[19]  Samuel F. Bakhoum,et al.  Chromosomal instability drives metastasis through a cytosolic DNA response , 2017, Nature.

[20]  Juan José Granados-Romero,et al.  Colorectal cancer: a review , 2017 .

[21]  P. Park,et al.  A molecular portrait of microsatellite instability across multiple cancers , 2016, Nature Communications.

[22]  Allison P. Heath,et al.  Toward a Shared Vision for Cancer Genomic Data. , 2016, The New England journal of medicine.

[23]  R. Strausberg,et al.  Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer , 2016, Science Translational Medicine.

[24]  M. Hande,et al.  Chromosomal instability--mechanisms and consequences. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[25]  Maurits J. J. Dijkstra,et al.  High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer , 2015, PloS one.

[26]  Jeffrey S. Morris,et al.  The Consensus Molecular Subtypes of Colorectal Cancer , 2015, Nature Medicine.

[27]  I. Soubeyran,et al.  Impact of chromosomal instability on colorectal cancer progression and outcome , 2014, BMC Cancer.

[28]  N. McGranahan,et al.  The causes and consequences of genetic heterogeneity in cancer evolution , 2013, Nature.

[29]  W. Lam,et al.  The detection and implication of genome instability in cancer , 2013, Cancer and Metastasis Reviews.

[30]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of human colon and rectal cancer , 2012, Nature.

[31]  Zhiyuan Shen.  Genomic instability and cancer: an introduction. , 2011, Journal of molecular cell biology.

[32]  Ajay N. Jain,et al.  Fractional Genomic Alteration Detected by Array-Based Comparative Genomic Hybridization Independently Predicts Survival after Hepatic Resection for Metastatic Colorectal Cancer , 2005, Clinical Cancer Research.

[33]  Stef van Lieshout,et al.  GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes , 2016, F1000Research.

[34]  P. Laurent-Puig.  [Genetic alterations in colorectal cancer]. , 1994, Annales de pathologie.

[35]  J. Hardcastle,et al.  Colorectal cancer , 1993, Europe Against Cancer European Commission Series for General Practitioners.