Long‐term inhibition of miR‐21 leads to reduction of obesity in db/db mice

To assess the effect of long‐term pharmacological inhibition of miR‐21 in a model of metabolic syndrome and obesity.

[1]  M. Böhm,et al.  Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. , 2013, European heart journal.

[2]  E. van Rooij,et al.  Inhibition of MicroRNA-92a Protects Against Ischemia/Reperfusion Injury in a Large-Animal Model , 2013, Circulation.

[3]  V. Davé,et al.  Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression , 2013, The Journal of Biological Chemistry.

[4]  Yu-mei Li,et al.  Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression , 2013, Molecular Biology Reports.

[5]  Hong Zhou,et al.  miR‐21 modulates the ERK–MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation , 2013, Journal of cellular biochemistry.

[6]  C. Croce,et al.  MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer , 2013, Immunological reviews.

[7]  S. Kauppinen,et al.  Treatment of HCV infection by targeting microRNA. , 2013, The New England journal of medicine.

[8]  S. Dimmeler,et al.  MicroRNAs in age-related diseases , 2013, EMBO molecular medicine.

[9]  L. Liaw,et al.  Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction. , 2012, The British journal of nutrition.

[10]  J. Levy,et al.  PTEN mutations as a cause of constitutive insulin sensitivity and obesity. , 2012, The New England journal of medicine.

[11]  Apostolos Zaravinos,et al.  Differential Expression of MicroRNAs in Adipose Tissue after Long-Term High-Fat Diet-Induced Obesity in Mice , 2012, PloS one.

[12]  P. Pandolfi,et al.  Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State , 2012, Cell.

[13]  S. Yuda,et al.  Diabetic cardiomyopathy: pathophysiology and clinical features , 2012, Heart Failure Reviews.

[14]  A. Efeyan,et al.  Pten positively regulates brown adipose function, energy expenditure, and longevity. , 2012, Cell metabolism.

[15]  J. M. Suh,et al.  A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis , 2012, Nature.

[16]  Hyunjin Cho,et al.  MicroRNA 21 regulates the proliferation of human adipose tissue‐derived mesenchymal stem cells and high‐fat diet‐induced obesity alters microRNA 21 expression in white adipose tissues , 2012, Journal of cellular physiology.

[17]  T. Thum.  MicroRNA therapeutics in cardiovascular medicine , 2012, EMBO molecular medicine.

[18]  Christian Gieger,et al.  Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile , 2011, Nature Genetics.

[19]  T. Thum,et al.  Regulation and function of miRNA-21 in health and disease , 2011, RNA biology.

[20]  J. Kaufman,et al.  Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome , 2011, Diabetes.

[21]  J. Timmons,et al.  Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity , 2011, BMC endocrine disorders.

[22]  P. Linsley,et al.  Comparison of different miR-21 inhibitor chemistries in a cardiac disease model. , 2011, The Journal of clinical investigation.

[23]  S. Kauppinen,et al.  Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. , 2010, The Journal of clinical investigation.

[24]  L. Liaw,et al.  Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  C. Emanueli,et al.  Vitamin B1 Analog Benfotiamine Prevents Diabetes-Induced Diastolic Dysfunction and Heart Failure Through Akt/Pim-1–Mediated Survival Pathway , 2010, Circulation. Heart failure.

[26]  Y. Bae,et al.  MiR‐21 Regulates Adipogenic Differentiation through the Modulation of TGF‐β Signaling in Mesenchymal Stem Cells Derived from Human Adipose Tissue , 2009, Stem cells.

[27]  G. Nuovo,et al.  MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. , 2009, Cardiovascular research.

[28]  W. Rottbauer,et al.  MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts , 2008, Nature.

[29]  Danish Sayed,et al.  MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. , 2008, Molecular biology of the cell.

[30]  P. Herijgers,et al.  Type II diabetic mice exhibit contractile dysfunction but maintain cardiac output by favourable loading conditions , 2006, European journal of heart failure.

[31]  Brian Rodrigues,et al.  Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. , 2006, American journal of physiology. Heart and circulatory physiology.

[32]  R. Kitazawa,et al.  MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. , 2006, The Journal of clinical investigation.

[33]  A. Phan,et al.  Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[34]  F. Newell,et al.  Fibroblast growth factor 1: a key regulator of human adipogenesis. , 2004, Diabetes.

[35]  V. Ambros.  The functions of animal microRNAs , 2004, Nature.

[36]  R. Leibel,et al.  Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[37]  G. Guy,et al.  Sprouty: how does the branch manager work? , 2003, Journal of Cell Science.

[38]  D. Severson,et al.  Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice. , 2002, American journal of physiology. Heart and circulatory physiology.

[39]  L. Tartaglia,et al.  Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice , 1996, Cell.

[40]  D. Severson,et al.  Diabetes in mice with monogenic obesity: the db/db mouse and its use in the study of cardiac consequences. , 2012, Methods in molecular biology.