Longitudinal analysis of Epstein–Barr virus‐associated illness

© 2008 Japan Pediatric Society Host immune status, such as cytokine production by activated cells, and immunodefi cient status with respect to other pathogens, complicates the pathogenesis of Epstein – Barr virus (EBV)associated illnesses, such as EBV-associated hemophago cytic syndrome (EBV-AHS) and chronic active EBV infection (CAEBV). 1 – 3 But no report has assessed the relationship between EBV load and cytokine profi les. Here we report two cases of EBV-associated illness that presented as EBV-AHS, with longitudinal analyses of both the EBV load and cytokine profi le.

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