Splenic granulomas in Crohn disease.

Granulomas have been described in a wide variety of organs in patients with Crohn disease, but not in spleen. This report describes a patient with noncaseating granulomas of the liver and spleen that responded promptly and fully to glucocorticoid therapy.

[1]  J. Piette,et al.  Disseminated Aseptic Abscesses Associated with Crohn's Disease (A New Entity?) , 1998, Digestive Diseases and Sciences.

[2]  T. Arakawa,et al.  Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[3]  T. Yoshida,et al.  In vivo expression of monokine and inducible nitric oxide synthase in experimentally induced pulmonary granulomatous inflammation. Evidence for sequential production of interleukin-1, inducible nitric oxide synthase, and tumor necrosis factor. , 1995, The American journal of pathology.

[4]  S. Kunkel,et al.  Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF. , 1995, Journal of immunology.

[5]  J. Warren,et al.  Regulatory roles of tumor necrosis factor-α and interleukin-1β in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat , 1995 .

[6]  J. Warren,et al.  Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat. , 1995, The American journal of pathology.

[7]  I. Cree,et al.  Detection of tumour necrosis factor alpha in sarcoidosis and tuberculosis granulomas using in situ hybridisation. , 1994, Journal of clinical pathology.

[8]  J. Warren,et al.  Monocyte chemoattractant protein 1 in a rat model of pulmonary granulomatosis. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[9]  R. Walker,et al.  Granulomatous hepatitis: a retrospective review of 88 cases at the Mayo Clinic. , 1991, Mayo Clinic proceedings.

[10]  D. Weatherall,et al.  A Chronic Granulomatous Syndrome of Unknown Origin , 1990, Medicine.

[11]  R. Russell,et al.  Hepatic granulomas: experience over a 10-year period in the West of Scotland. , 1982, The Quarterly journal of medicine.

[12]  M. Eliakim,et al.  Idiopathic granulomatous hepatitis with a prolonged course: effect of corticosteroid therapy. , 1978, Digestion.

[13]  D. Kleiner GRANULOMAS OF THE LIVER , 1975, The Lancet.

[14]  A. Price,et al.  Inflammatory bowel disease: the surgical pathology of Crohn's disease and ulcerative colitis. , 1975, Human pathology.

[15]  S. Wolff,et al.  GRANULOMATOUS HEPATITIS AND PROLONGED FEVER OF UNKNOWN ORIGIN: A STUDY FO 13 PATIENTS , 1973, Medicine.