Functional consequences of inhibiting serotonin uptake with fluoxetine in rats.

: Fluoxetine alone enhances central serotonin function as measured by a variety of test systems and potentiates the effects of serotonin precursors. Table 1 lists various effects of tryptophan or 5HTP that have been potentiated by fluoxetine. This potentiation or synergistic interactions between fluoxetine and L-5HTP constitute excellent evidence that any given effect is influenced by a serotonin synaptic connection.