Pulvinar lesions in monkeys produce abnormal scanning of a complex visual array

Abstract Eye movements of normal monkeys and monkeys with pulvinar lesions were recorded on video tape as the animals spontaneously scanned a complex stimulus array. During the test session, color was added to one stimulus in the array. Although monkeys with pulvinar lesions were not impaired in either visual orientation or habituation to this novel stimulus, their eye movements were abnormal in two ways. First, they appeared visually captured by the stimuli, making few saccades off the array. Second, their fixations were abnormally prolonged. These eye-movement abnormalities appeared to be associated with a disorder in visual processing rather than an impairment in oculomotor control.

[1]  K. Pribram,et al.  The effect of resections of the inferotemporal cortex or the amygdala on visual orienting and habituation. , 1972, Neuropsychologia.

[2]  W. Nauta,et al.  Subcortical projections from the temporal neocortex in Macaca mulatta , 1956 .

[3]  R. Wurtz,et al.  Activity of superior colliculus in behaving monkey. IV. Effects of lesions on eye movements. , 1972, Journal of neurophysiology.

[4]  T. P. S. Powell,et al.  Certain connections of the visual cortex of the monkey shown by the use of horseradish peroxidase , 1975, Brain Research.

[5]  E. Siqueira The temporo-pulvinar connections in the rhesus monkey. , 1965, Archives of neurology.

[6]  J. Kaas,et al.  A representation of the visual field in the inferior nucleus of the pulvinar in the owl monkey (Aotus trivirgatus). , 1972, Brain research.

[7]  Norman H. Mackworth,et al.  The wide-angle reflection eye camera for visual choice and pupil size , 1968 .

[8]  R H Wurtz,et al.  Role of striate cortex and superior colliculus in visual guidance of saccadic eye movements in monkeys. , 1977, Journal of neurophysiology.

[9]  D B Lindsley,et al.  Effect of pulvinar lesions on visual pattern discrimination in monkeys. , 1976, Journal of neurophysiology.

[10]  W. E. Clark,et al.  THE CORTICAL PROJECTION OF THE PULVINAR IN THE MACAQUE MONKEY , 1937 .

[11]  J. Lund,et al.  The origin of efferent pathways from the primary visual cortex, area 17, of the macaque monkey as shown by retrograde transport of horseradish peroxidase , 1975, The Journal of comparative neurology.

[12]  R. Gattass,et al.  Visuotopic organization of the Cebus pulvinar: A double representation of the contralateral hemifield , 1978, Brain Research.

[13]  A. Hendrickson,et al.  Pathways between striate cortex and subcortical regions in Macaca mulatta and Saimiri sciureus: Evidence for a reciprocal pulvinar connection , 1976, Experimental Neurology.

[14]  L. Benevento,et al.  The cortical projections of the inferior pulvinar and adjacent lateral pulvinar in the rhesus monkey (macaca mulatta): An autoradiographic study , 1976, Brain Research.

[15]  M Mishkin,et al.  Visual discrimination in the monkey following serial ablation of inferotemporal and preoccipital cortex. , 1968, Journal of comparative and physiological psychology.

[16]  N. Mackworth,et al.  Habituation of the visual orienting response in young children1, 2 , 1970 .

[17]  J. Campos-Ortega,et al.  The descending projections from the cortical visual fields of Macaca mulatta with particular reference to the question of a cortico-lateral geniculate-pathway. , 1970, Brain, behavior and evolution.

[18]  M H Bagshaw,et al.  Method for Recording and Analyzing Visual Fixations in the Unrestrained Monkey , 1970, Perceptual and motor skills.

[19]  P. Salapatek Chapter 3 – Pattern Perception in Early Infancy1 , 1975 .

[20]  L. Benevento,et al.  The ascending projections of the superior colliculus in the rhesus monkey (Macaca mulatta) , 1975, The Journal of comparative neurology.

[21]  Leslie G. Ungerleider,et al.  Pulvinar lesions in monkeys produce abnormal eye movements during visual discrimination training , 1977, Brain Research.

[22]  D. Denny-Brown,et al.  The Midbrain and Motor Integration , 1962, Proceedings of the Royal Society of Medicine.

[23]  L H Mathers,et al.  Tectal projection to the posterior thalamus of the squirrel monkey. , 1971, Brain research.

[24]  Mortimer Mishkin,et al.  Cortical Visual Areas and Their Interactions , 1972 .

[25]  M Mishkin,et al.  Further evidence on the locus of the visual area in the temporal lobe of the monkey. , 1969, Experimental neurology.

[26]  M. Colonnier,et al.  Thalamic projections of the superior colliculus in the rhesus monkey, Macaca mulatta. A light and electron microscopic study , 1977, The Journal of comparative neurology.

[27]  Leslie G. Ungerleider,et al.  Inferotemporal versus combined pulvinar-prestriate lesions in the rhesus monkey: Effects on color, object and pattern discrimination , 1977, Neuropsychologia.

[28]  K. Chow Lack of behavioral effects following destruction of some thalamic association nuclei in monkey. , 1954, A.M.A. archives of neurology and psychiatry.

[29]  S C Rapisardi,et al.  Visual and somatosensory receptive fields of neurons in the squirrel monkey pulvinar. , 1973, Brain research.

[30]  P. Schiller,et al.  The role of the monkey superior colliculus in eye movement and vision. , 1972, Investigative ophthalmology.

[31]  Feed A. Mettler Corticifugal fiber connections of the cortex of Macaca mullatta. The occipital region , 1935 .

[32]  K. Chow,et al.  A retrograde cell degeneration study of the cortical projection field of the pulvinar in the monkey , 1950, The Journal of comparative neurology.

[33]  J. C. Vuletin,et al.  A Light and Electron Microscopic Study , 1976 .

[34]  John Q. Trojanowski,et al.  Peroxidase labeled subcortical afferents to pulvinar in rhesus monkey , 1975, Brain Research.

[35]  R H Wurtz,et al.  The primate superior colliculus and the shift of visual attention. , 1972, Investigative ophthalmology.

[36]  L. Chalupa,et al.  A review of cat and monkey studies implicating the pulvinar in visual function. , 1977, Behavioral biology.

[37]  L. Benevento,et al.  Extrageniculate projections to layers VI and I of striate cortex (area 17) in the rhesus monkey (Macaca mulatta) , 1975, Brain Research.