Associations between amyloid β and white matter hyperintensities: A systematic review

This systematic review synthesizes current evidence for associations between cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white matter hyperintensity (WMH) burden on magnetic resonance imaging in healthy elderly adults and individuals with cognitive impairment and dementia.

[1]  S. Pocock,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. , 2007, Preventive medicine.

[2]  J. S. Kim,et al.  Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B , 2011, Neurology.

[3]  E. Rostrup,et al.  Decline in intelligence is associated with progression in white matter hyperintensity volume , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[4]  Olivier Salvado,et al.  Incidence of cerebral microbleeds in preclinical Alzheimer disease , 2014, Neurology.

[5]  P. Scheltens,et al.  White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging , 1999, Journal of neurology, neurosurgery, and psychiatry.

[6]  Miranka Wirth,et al.  Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults , 2014, Neurobiology of Aging.

[7]  S le Cessie,et al.  Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT) , 2010, BMJ : British Medical Journal.

[8]  Jordan Muraskin,et al.  White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? , 2013, JAMA neurology.

[9]  K. McGuire,et al.  Digging the New York City Skyline: Soil Fungal Communities in Green Roofs and City Parks , 2013, PloS one.

[10]  B C Bowen,et al.  MR signal abnormalities in memory disorder and dementia. , 1990, AJNR. American journal of neuroradiology.

[11]  Sue J. Kang,et al.  The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments , 2013, Neurobiology of Aging.

[12]  M. Wortmann,et al.  World Alzheimer report 2014: Dementia and risk reduction , 2015, Alzheimer's & Dementia.

[13]  D. Werring,et al.  White matter hyperintensities are associated with amyloid burden in APOE4 non-carriers. , 2014, Journal of Alzheimer's disease : JAD.

[14]  M. Weiner,et al.  Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment , 2014, Neurobiology of Aging.

[15]  T. Duong,et al.  White matter lesion load is associated with resting state functional MRI activity and amyloid pet but not FDG in mild cognitive impairment and early alzheimer's disease patients , 2015, Journal of magnetic resonance imaging : JMRI.

[16]  C. Sorg,et al.  Small Vessel Disease, but Neither Amyloid Load nor Metabolic Deficit, Is Dependent on Age at Onset in Alzheimer’s Disease , 2015, Biological Psychiatry.

[17]  L. Kuller,et al.  Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults , 2013, Neurology.

[18]  Brian A. Gordon,et al.  The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia , 2015, NeuroImage: Clinical.

[19]  E. Ross,et al.  Philosophy of Science Association , 2022 .

[20]  A. Alavi,et al.  MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. , 1987, AJR. American journal of roentgenology.

[21]  A. Brun,et al.  A Clinico-Pathological Study of Heart and Brain Lesions in Vascular Dementia , 2005, Dementia and Geriatric Cognitive Disorders.

[22]  H. Feldman,et al.  Periventricular hyperintensities are associated with elevated cerebral amyloid , 2016, Neurology.

[23]  D. Werring,et al.  Blood viscosity in subcortical vascular mild cognitive impairment with versus without cerebral amyloid burden. , 2014, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[24]  W. Jagust,et al.  Coronary risk correlates with cerebral amyloid deposition , 2012, Neurobiology of Aging.

[25]  A. Brickman,et al.  APOE ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role? , 2014, Alzheimer's & Dementia.

[26]  Paul Maruff,et al.  Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. , 2007, Brain : a journal of neurology.

[27]  Christos Davatzikos,et al.  White matter hyperintensities and imaging patterns of brain ageing in the general population. , 2016, Brain : a journal of neurology.

[28]  H. Braak,et al.  Staging of alzheimer's disease-related neurofibrillary changes , 1995, Neurobiology of Aging.

[29]  Nick C Fox,et al.  White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network , 2016, Annals of neurology.

[30]  W. Markesbery,et al.  Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study , 2002, Annals of neurology.

[31]  Jae Seung Kim,et al.  Seoul criteria for PiB(−) subcortical vascular dementia based on clinical and MRI variables , 2014, Neurology.

[32]  C. Jack,et al.  Brain injury biomarkers are not dependent on β‐amyloid in normal elderly , 2013, Annals of neurology.

[33]  William J Powers,et al.  Autoregulation of Cerebral Blood Flow to Changes in Arterial Pressure in Mild Alzheimer's Disease , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[34]  Y. J. Kim,et al.  White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia , 2015, European journal of neurology.

[35]  Martin Prince,et al.  World Alzheimer Report 2014: Dementia and risk reduction: An analysis of protective and modifiable risk factors , 2014 .

[36]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[37]  C. Rowe,et al.  Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging , 2010, Neurobiology of Aging.

[38]  Alan C. Evans,et al.  Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders , 2014, PLoS Comput. Biol..

[39]  Florian Auer,et al.  White matter hyperintensities predict amyloid increase in Alzheimer's disease , 2012, Neurobiology of Aging.

[40]  Nick C Fox,et al.  Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration , 2013, The Lancet Neurology.

[41]  Nick C Fox,et al.  Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease , 2013, Proceedings of the National Academy of Sciences.

[42]  Keith A. Johnson,et al.  Cerebral amyloid angiopathy burden associated with leukoaraiosis: A positron emission tomography/magnetic resonance imaging study , 2013, Annals of neurology.

[43]  L. Pantoni Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges , 2010, The Lancet Neurology.

[44]  Thomas Wisniewski,et al.  Clearance systems in the brain—implications for Alzheimer disease , 2015, Nature Reviews Neurology.

[45]  Kenneth Rockwood,et al.  Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement , 2014, Alzheimer disease and associated disorders.

[46]  M. Weiner,et al.  Individual Subject Classification of Mixed Dementia from Pure Subcortical Vascular Dementia Based on Subcortical Shape Analysis , 2013, PloS one.

[47]  H. Markus,et al.  The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis , 2010, BMJ : British Medical Journal.

[48]  J. Becker,et al.  Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old , 2014, Neurology.

[49]  Jae Seung Kim,et al.  Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease , 2013, Neurology.

[50]  Mette E. Haahr,et al.  Lack of association between prior depressive episodes and cerebral [11C]PiB binding , 2012, Neurobiology of Aging.

[51]  T. Yen,et al.  Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography , 2012, Journal of the Neurological Sciences.

[52]  D. Werring,et al.  Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment , 2013, Annals of neurology.

[53]  I. Deary,et al.  APOE/TOMM 40 genetic loci, white matter hyperintensities, and cerebral microbleeds , 2015, International journal of stroke : official journal of the International Stroke Society.

[54]  M. Munafo,et al.  A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort. , 2016, Journal of Alzheimer's disease : JAD.

[55]  C. Jack,et al.  Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly , 2015, Brain : a journal of neurology.

[56]  J. H. Lee,et al.  Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type , 2014, European journal of neurology.

[57]  Cindee M. Madison,et al.  Cerebrovascular disease, beta-amyloid, and cognition in aging , 2012, Neurobiology of Aging.

[58]  M. Weiner,et al.  Effects of APOE ɛ4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment , 2013, Neurobiology of Aging.

[59]  Susan M Resnick,et al.  Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern? , 2008, Journal of Nuclear Medicine.

[60]  Rebecca F. Halperin,et al.  A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. , 2007, The Journal of clinical psychiatry.

[61]  P. Vemuri,et al.  Brain β-amyloid load approaches a plateau , 2013, Neurology.

[62]  P. Matthews,et al.  White matter lesion progression, brain atrophy, and cognitive decline: The Austrian stroke prevention study , 2005, Annals of neurology.

[63]  S. Black,et al.  Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2011, Stroke.

[64]  Miranka Wirth,et al.  Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions , 2014, Neurology.

[65]  W. Klunk,et al.  Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. , 2001, Life sciences.

[66]  Masanori Ichise,et al.  Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated , 2015, Neuroscience Letters.

[67]  Cindee M. Madison,et al.  Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. , 2013, JAMA neurology.

[68]  Jae Seung Kim,et al.  Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients , 2015, Alzheimer's & Dementia.

[69]  Vijaya L. Melnick,et al.  Alzheimer’s Dementia , 1985, Contemporary Issues in Biomedicine, Ethics, and Society.

[70]  D. Werring,et al.  White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid , 2015, Brain pathology.

[71]  L. Kuller,et al.  Arterial stiffness is associated with amyloid deposition in the brain independent of blood pressure , 2013, Alzheimer's & Dementia.

[72]  D. Na,et al.  Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status. , 2015, Journal of affective disorders.

[73]  Cindee M. Madison,et al.  Cortical thickness mediates the effect of β-amyloid on episodic memory , 2014, Neurology.

[74]  C. Jack,et al.  Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade , 2010, The Lancet Neurology.

[75]  K. Jellinger The enigma of mixed dementia , 2007, Alzheimer's & Dementia.

[76]  J. Haxby,et al.  The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults , 1995, Neurology.

[77]  Tyler E. Benedum,et al.  Preclinical Properties of 18F-AV-45: A PET Agent for Aβ Plaques in the Brain , 2009, Journal of Nuclear Medicine.

[78]  L. Wilkins Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B , 2011, Neurology.

[79]  Cindee M. Madison,et al.  The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction. , 2013, JAMA neurology.

[80]  D. Moher,et al.  Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2009, Physical therapy.

[81]  W. Jagust,et al.  Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment. , 2015, The journal of prevention of Alzheimer's disease.

[82]  W. Klunk,et al.  Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.

[83]  Nick C. Fox,et al.  Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease , 2015, Neurobiology of Aging.

[84]  N. De Stefano,et al.  APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.