Background: Acetabular fractures is a break in the socket portion of the “ball and socket” hip joint. The operative treatment often necessitates extensive surgical exposure. Aim of the study: To investigate the risk factors of SSI after acetabular fracture surgery and to perform a meta-analysis of case-controlled trials (CCTs) to determine whether there were any significant differences in the average fracture end reset satisfaction rate, early/late complication rates, and the approach during operation and BMI. Subject and Methods: This Meta-analysis was a quantitative, formal, epidemiological study design used to systematically assess previous research studies to derive conclusions about that body of research. Computerized research was performed in PubMed, Medline, Elsevier, Scopus, Google scholar and Cochrane Library database to identify the relevant literatures published from January 2010 until 20 May 2021. The search included the single keyword or in combination: a “Surgical Site infection and acetabular fixation” “infection and pelvic fractures” “risk factors of infection and acetabular fracture fixation. Data entered organized in Microsoft excel 2010 then exported to comprehensive meta-analysis software version 3 Pooled: for analysis of multiple studies, and found adjusted accumulative outcome. Z score method: to test difference in mean. Test for heterogeneity: Cochran’s Q test and I 2 : Under null, it is approximately distributed as a chisquare with k-1 degrees of freedom for test heterogeneity and homogeneity of studies results and finding. Results: The BMI was found to be another covariate influencing SSI in patients with acetabular fracture, increasing the Surgical site infection (SSI) by about 1.4 times. We found that (mean±SD 1.3-7.69) in all study in addition ( Z score 2.099 ) in pooled analysis indicates that anterior approach increased risk of SSI in orthopedic surgery. Also (Cochran Q 7.88) and I 2 (Inconsistency 5.12) that’s means no significant heterogeneity and we found agreement between studied Patients admitted to the ICU have a higher risk of nosocomial infection than other hospitalized patients. We also found that (mean±SD 10.42±2.85) in all study in addition (Z score 25.96) in pooled analysis indicates that ICU stay increased risk of SSI in orthopedic surgery. Also (Cochran Q7.12) and I 2 (Inconsistency 6.33) that’s means no significant heterogeneity and we found agreement between studied. Conclusions: According to the collected data from the included studies showed that, body mass index, ICU stay, and injury severity score all these are risk factors after operation. Other side, according to approach, we founded that anterior approach a significant risk in acetabular fracture management.
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