Cytopathologic Diagnosis of Spontaneous Infarction of Fibroadenoma of the Breast / Spontan Enfark Gösteren Meme Fibroadenomunun Sitopatolojik Tanısı

Abstract Infarction is an uncommon event in a fibroadenoma, which is the commonest benign tumor of the breast. Most often it occurs in pregnancy, lactation or is secondary to fine needle aspiration. Spontaneous infarction of a fibroadenoma in the absence of a predisposing condition is very rare. The cytopathologic features of infarction are necrosis and worrisome nuclear features, which are often misinterpreted as either inflammation or malignancy. We detail a report of accurate cytopathologic diagnosis of spontaneous infarction of fibroadenoma in a 17-year-old adolescent non pregnant girl. Careful attention to the cytopathologic clues like uniform thickness of the necrotic epithelial fragments, branching pattern reminiscent of the staghorn pattern despite atypical nuclear features and clinical details like young age of the patient and recent onset pain in a pre-existing lump helped arrive at the correct diagnosis and spared the patient of a radical excision. To the best of our knowledge, there are no earlier reports of correct cytopathologic diagnosis. Öz Memenin en sık benign tümörü olan fibroadenomda infarkt nadiren görülür. En sık olarak gebelik ve laktasyon dönemlerinde ya da ince iğne aspirasyonuna bağlı olarak gelişir. Bu predispozan durumların yokluğunda, fibroadenomun spontan infarktı son derece nadirdir. Enfarktın sitopatolojik özellikleri, nekroz ve kuşkulu nükleer özelliklerdir. Bunlar inflamasyon ya da malignite olarak yanlış yorumlanabilir. Bu olgu sunumunda, 17 yaşındaki bir hastada gelişen spontan fibroadenom infarktının sitopatolojik özellikleri sunulmaktadır. Nekrotik epitelyal fragmanların uniform kalınlığı, geyik boynuzu şeklinde dallanma patterni, atipik nükleer özellikler ve hastanın yaşı, uzun süredir var olan kitlede son dönemde başlayan ağrı gibi klinik ayrıntılar doğru tanıya ulaşmada ve hastayı radikal eksizyondan alıkoymada yardımcı oldu. Literatürde doğru sitopatolojik tanıya ulaşılan olgu bildirimine rastlanmadı.

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