Perirhinal Cortex and its Neighbours in the Medial Temporal Lobe: Contributions to Memory and Perception

As promised in the Introduction, this Special Issue presents several recurring themes concerning the perirhinal cortex and its neighbours within the medial temporal lobe (MTL). First, although orthodoxy insists that the diverse constituents of the MTL operate as a single functional entity, several papers presented here challenge that idea, although some defend it. Second, although many experts hold that the MTL subserves memory but not perception, several papers presented here point to a role for certain MTL structures in both. Third, although some researchers have invoked “species differences” to account for discrepant findings, several papers presented here document a striking convergence of findings in humans, nonhuman primates, and rodents. We close this Special Issue by high-lighting these recurring themes, acknowledging discrepant findings and pointing to future research that might resolve some current controversies.

[1]  HighWire Press Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[2]  M. W. Brown,et al.  Neuronal evidence that inferomedial temporal cortex is more important than hippocampus in certain processes underlying recognition memory , 1987, Brain Research.

[3]  Y. Miyashita Neuronal correlate of visual associative long-term memory in the primate temporal cortex , 1988, Nature.

[4]  M. Mishkin,et al.  A selective mnemonic role for the hippocampus in monkeys: memory for the location of objects , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  Y. Miyashita,et al.  Neural organization for the long-term memory of paired associates , 1991, Nature.

[6]  J. Ringo,et al.  Memory decays at the same rate in macaques with and without brain lesions when expressed in d′ or arcsine terms , 1991, Behavioural Brain Research.

[7]  Y. Miyashita,et al.  Memory and imagery in the temporal lobe , 1993, Current Opinion in Neurobiology.

[8]  M. Mishkin,et al.  Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  M Mishkin,et al.  Neural substrates of visual stimulus-stimulus association in rhesus monkeys , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  R. Desimone,et al.  The representation of stimulus familiarity in anterior inferior temporal cortex. , 1993, Journal of neurophysiology.

[11]  R. Desimone,et al.  Parallel neuronal mechanisms for short-term memory. , 1994, Science.

[12]  E. Murray,et al.  Preserved Recognition Memory for Small Sets, and Impaired Stimulus Identification for Large Sets, Following Rhinal Cortex Ablations in Monkeys , 1994, The European journal of neuroscience.

[13]  D. Gaffan Scene-Specific Memory for Objects: A Model of Episodic Memory Impairment in Monkeys with Fornix Transection , 1994, Journal of Cognitive Neuroscience.

[14]  W. Suzuki,et al.  Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  M. W. Brown,et al.  Neuronal Sianallina of Information Imoortant to Visual Recognition‐Memory in Rat Rhinal aid Neighbouring Cortices , 1995, The European journal of neuroscience.

[16]  Elisabeth A. Murray,et al.  What have ablation studies told us about the neural substrates of stimulus memory , 1996 .

[17]  J. Ringo,et al.  Mnemonic Responses of Single Units Recorded from Monkey Inferotemporal Cortex, Accessed via Transcommissural Versus Direct Pathways: A Dissociation between Unit Activity and Behavior , 1996, The Journal of Neuroscience.

[18]  M. D’Esposito,et al.  The parahippocampus subserves topographical learning in man , 1996, NeuroImage.

[19]  Wendy A. Suzuki,et al.  Neuroanatomy of the monkey entorhinal, perirhinal and parahippocampal cortices: Organization of cortical inputs and interconnections with amygdala and striatum , 1996 .

[20]  Y. Miyashita,et al.  Formation of mnemonic neuronal responses to visual paired associates in inferotemporal cortex is impaired by perirhinal and entorhinal lesions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Richard S. J. Frackowiak,et al.  Learning to find your way: a role for the human hippocampal formation , 1996, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[22]  D. Gaffan,et al.  Interaction of Perirhinal Cortex with the Fornix–Fimbria: Memory for Objects and “Object-in-Place” Memory , 1996, The Journal of Neuroscience.

[23]  J. N. Rawlins,et al.  The hippocampus, objects, and their contexts. , 1997, Behavioral neuroscience.

[24]  E. Murray,et al.  Rhinal Cortex Removal Produces Amnesia for Preoperatively Learned Discrimination Problems But Fails to Disrupt Postoperative Acquisition and Retention in Rhesus Monkeys , 1997, The Journal of Neuroscience.

[25]  Keiji Tanaka Mechanisms of visual object recognition: monkey and human studies , 1997, Current Opinion in Neurobiology.

[26]  Nancy Kanwisher,et al.  A cortical representation of the local visual environment , 1998, Nature.

[27]  D. Gaffan,et al.  Interaction of frontal and perirhinal cortices in visual object recognition memory in monkeys , 1998, The European journal of neuroscience.

[28]  D. Gaffan,et al.  Learning and transfer of object-reward associations and the role of the perirhinal cortex. , 1998, Behavioral neuroscience.

[29]  L. Squire,et al.  The human perirhinal cortex and recognition memory , 1998, Hippocampus.

[30]  E. Murray,et al.  Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversals. , 1998, Behavioral neuroscience.

[31]  M. Mishkin,et al.  Object Recognition and Location Memory in Monkeys with Excitotoxic Lesions of the Amygdala and Hippocampus , 1998, The Journal of Neuroscience.

[32]  D. Gaffan,et al.  Perirhinal cortex ablation impairs configural learning and paired–associate learning equally , 1998, Neuropsychologia.

[33]  E. Murray,et al.  Cross-modal associations, intramodal associations, and object identification in macaque monkeys , 1998 .

[34]  D. Gaffan,et al.  Perirhinal Cortex Ablation Impairs Visual Object Identification , 1998, The Journal of Neuroscience.

[35]  J. Rawlins,et al.  Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions. , 1999, Behavioral neuroscience.

[36]  T. Bussey,et al.  Perceptual–mnemonic functions of the perirhinal cortex , 1999, Trends in Cognitive Sciences.

[37]  R. Desimone,et al.  Responses of Macaque Perirhinal Neurons during and after Visual Stimulus Association Learning , 1999, The Journal of Neuroscience.

[38]  R. Killiany,et al.  Hippocampal formation lesions produce memory impairment in the rhesus monkey , 1999, Hippocampus.

[39]  H. Scharfman,et al.  The parahippocampal region. Implications for neurological and psychiatric diseases. Introduction. , 2000, Annals of the New York Academy of Sciences.

[40]  R. Burwell The Parahippocampal Region: Corticocortical Connectivity , 2000, Annals of the New York Academy of Sciences.

[41]  L. Squire,et al.  Intact visual perceptual discrimination in humans in the absence of perirhinal cortex. , 2000, Learning & memory.

[42]  L M Saksida,et al.  The Parahippocampal Region and Object Identification , 2000, Annals of the New York Academy of Sciences.

[43]  L R Squire,et al.  Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex. , 2000, Learning & memory.

[44]  S. Gutnikov,et al.  Perceptual and Mnemonic Matching-To-Sample in Humans: Contributions of The Hippocampus, Perirhinal and Other Medial Temporal Lobe Cortices , 2000, Cortex.

[45]  B. Richmond,et al.  Response differences in monkey TE and perirhinal cortex: stimulus association related to reward schedules. , 2000, Journal of neurophysiology.

[46]  D G Gadian,et al.  Dissociations in cognitive memory: the syndrome of developmental amnesia. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[47]  E. Rolls,et al.  Selective Perceptual Impairments After Perirhinal Cortex Ablation , 2001, The Journal of Neuroscience.

[48]  D. Gaffan,et al.  What is a memory system? Horel's critique revisited , 2001, Behavioural Brain Research.

[49]  E. Murray,et al.  Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching‐to‐sample deficits in monkeys † , 2001, Hippocampus.

[50]  E. Murray,et al.  Neural substrates of crossmodal association memory in monkeys: the amygdala versus the anterior rhinal cortex. , 2001, Behavioral neuroscience.

[51]  L. Saksida,et al.  Perirhinal cortex resolves feature ambiguity in complex visual discriminations , 2002, The European journal of neuroscience.

[52]  Robert R Hampton,et al.  Learning of discriminations is impaired, but generalization to altered views is intact, in monkeys (Macaca mulatta) with perirhinal cortex removal. , 2002, Behavioral neuroscience.

[53]  David Gaffan,et al.  Against memory systems. , 2002, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[54]  L. Saksida,et al.  The organization of visual object representations: a connectionist model of effects of lesions in perirhinal cortex , 2002, The European journal of neuroscience.

[55]  M. Moser,et al.  Reduced fear expression after lesions of the ventral hippocampus , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Tarr,et al.  Visual Object Recognition , 1996, ISTCS.

[57]  M. Behrmann,et al.  Impact of learning on representation of parts and wholes in monkey inferotemporal cortex , 2002, Nature Neuroscience.

[58]  Ramona O Hopkins,et al.  Semantic Memory and the Human Hippocampus , 2003, Neuron.

[59]  M. Mishkin,et al.  One-Trial Memory for Object-Place Associations after Separate Lesions of Hippocampus and Posterior Parahippocampal Region in the Monkey , 2003, The Journal of Neuroscience.

[60]  Larry R Squire,et al.  Hippocampal damage equally impairs memory for single items and memory for conjunctions , 2003, Hippocampus.

[61]  L. Saksida,et al.  Impairments in visual discrimination after perirhinal cortex lesions: testing ‘declarative’ vs. ‘perceptual‐mnemonic’ views of perirhinal cortex function , 2003, The European journal of neuroscience.

[62]  Jason P. Mitchell,et al.  Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[63]  Christian Hölscher,et al.  Perirhinal cortex neuronal activity related to long‐term familiarity memory in the macaque , 2003, The European journal of neuroscience.

[64]  R. Clark,et al.  The medial temporal lobe. , 2004, Annual review of neuroscience.

[65]  M. W. Brown,et al.  Neuronal activity related to visual recognition memory: long-term memory and the encoding of recency and familiarity information in the primate anterior and medial inferior temporal and rhinal cortex , 2004, Experimental Brain Research.

[66]  Sabrina M. Tom,et al.  Dissociable correlates of recollection and familiarity within the medial temporal lobes , 2004, Neuropsychologia.

[67]  Guy B. Williams,et al.  The human perirhinal cortex and semantic memory , 2004, The European journal of neuroscience.

[68]  E. Murray,et al.  Selective hippocampal damage in rhesus monkeys impairs spatial memory in an open‐field test , 2004, Hippocampus.

[69]  Elisabeth A. Murray,et al.  What, if anything, is the medial temporal lobe, and how can the amygdala be part of it if there is no such thing? , 2004, Neurobiology of Learning and Memory.

[70]  J. Ringo,et al.  Investigation of long term recognition and association memory in unit responses from inferotemporal cortex , 1993, Experimental Brain Research.

[71]  D. Gaffan,et al.  Dissociated effects of perirhinal cortex ablation, fornix transection and amygdalectomy: evidence for multiple memory systems in the primate temporal lobe , 2004, Experimental Brain Research.

[72]  L. Squire,et al.  Recall and recognition are equally impaired in patients with selective hippocampal damage , 2004, Cognitive, affective & behavioral neuroscience.

[73]  A N Healey,et al.  Objects and positions in visual scenes: effects of perirhinal and postrhinal cortex lesions in the rat. , 2004, Behavioral neuroscience.

[74]  M. Buckley The Role of the Perirhinal Cortex and Hippocampus in Learning, Memory, and Perception , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[75]  J. Holdstock,et al.  The Quarterly Journal of Experimental Psychology , 2005 .

[76]  R. Henson A Mini-Review of fMRI Studies of Human Medial Temporal Lobe Activity Associated with Recognition Memory , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[77]  Robert R Hampton,et al.  Monkey Perirhinal Cortex is Critical for Visual Memory, but not for Visual Perception: Reexamination of the Behavioural Evidence from Monkeys , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[78]  Andy C. H. Lee,et al.  The Contribution of the Human Medial Temporal Lobe to Perception: Bridging the Gap between Animal and Human Studies , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[79]  Malcolm W. Brown,et al.  Contrasting Hippocampal and Perirhinalcortex Function using Immediate Early Gene Imaging , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[80]  R. Henson What can Functional Neuroimaging Tell the Experimental Psychologist? , 2005, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[81]  Russell A. Epstein,et al.  Perceptual deficits in amnesia: challenging the medial temporal lobe ‘mnemonic’ view , 2005, Neuropsychologia.

[82]  Lisa M Saksida,et al.  The Perceptual-Mnemonic/Feature Conjunction Model of Perirhinal Cortex Function , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[83]  M. Eacott,et al.  The Roles of Perirhinal Cortex, Postrhinal Cortex, and the Fornix in Memory for Objects, Contexts, and Events in the Rat , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[84]  Emmanuel A Stamatakis,et al.  The Anatomy of Object Processing: The Role of Anteromedial Temporal Cortex , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[85]  D. Gaffan,et al.  The Role of the Medial Temporal Lobe in Memory and Perception: Evidence from Rats, Nonhuman Primates and Humans , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[86]  E. T. Rolls,et al.  The Perirhinal Cortex and Long-Term Familiarity Memory , 2005, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[87]  L. Squire,et al.  Intact visual discrimination of complex and feature-ambiguous stimuli in the absence of perirhinal cortex. , 2005, Learning & memory.