The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.
暂无分享,去创建一个
H. Yatani | Y. Yokota | H. Egusa | Yoshihiro Akashi | M. Saeki | Y. Kamisaki | Sho Fukuyasu | Masanori Doi
[1] B. Cha,et al. Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo. , 2011, European journal of pharmacology.
[2] W. Sippl,et al. Activation, regulation, and inhibition of DYRK1A , 2011, The FEBS journal.
[3] S. Rivella,et al. Id1 Represses Osteoclast-Dependent Transcription and Affects Bone Formation and Hematopoiesis , 2009, PloS one.
[4] W. Becker,et al. Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation , 2009, The FEBS journal.
[5] Hong-Hee Kim,et al. Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis* , 2009, The Journal of Biological Chemistry.
[6] Y. Tabata,et al. Enhanced bone regeneration via multimodal actions of synthetic peptide SVVYGLR on osteoprogenitors and osteoclasts. , 2009, Biomaterials.
[7] H. Takayanagi,et al. Ca2+‐NFATc1 signaling is an essential axis of osteoclast differentiation , 2009, Immunological reviews.
[8] Jung Ha Kim,et al. Regulatory mechanism of NFATc1 in RANKL‐induced osteoclast activation , 2009, FEBS letters.
[9] H. Katus,et al. DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy* , 2009, The Journal of Biological Chemistry.
[10] O. MacDougald,et al. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. , 2008, Molecular endocrinology.
[11] P. Cohen,et al. The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.
[12] S. Fox,et al. RANKL-dependent and RANKL-independent mechanisms of macrophage-osteoclast differentiation in breast cancer , 2007, Breast Cancer Research and Treatment.
[13] Paul Nghiem,et al. Chemical genetics: elucidating biological systems with small-molecule compounds. , 2007, The Journal of investigative dermatology.
[14] R. Damoiseaux,et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. , 2007, Cell metabolism.
[15] N. Ohara,et al. Molecular analysis of RANKL‐independent cell fusion of osteoclast‐like cells induced by TNF‐α, lipopolysaccharide, or peptidoglycan , 2007, Journal of cellular biochemistry.
[16] S. Moro,et al. Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors , 2007, Chembiochem : a European journal of chemical biology.
[17] Jungchan Park,et al. Regulation of NFAT activation: a potential therapeutic target for immunosuppression. , 2006, Molecules and cells.
[18] Y. Gwack,et al. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT , 2006, Nature.
[19] Xin Gao,et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21 , 2006, Nature.
[20] Soo Young Lee,et al. Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. , 2006, Blood.
[21] Tak W. Mak,et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis , 2005, The Journal of experimental medicine.
[22] J. Steer,et al. Thapsigargin Modulates Osteoclastogenesis Through the Regulation of RANKL‐Induced Signaling Pathways and Reactive Oxygen Species Production , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[23] Y. Toyama,et al. DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells , 2005, The Journal of experimental medicine.
[24] Svetlana V Komarova,et al. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[25] Jun Jiang,et al. LTB4 Can Directly Stimulate Human Osteoclast Formation from PBMC Independent of RANKL , 2005, Artificial cells, blood substitutes, and immobilization biotechnology.
[26] B. DeDecker,et al. Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[27] Jian Wang,et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. , 2004, Biochemical and biophysical research communications.
[28] F. Aricioglu,et al. Effect of Harmane on the Convulsive Threshold in Epilepsy Models in Mice , 2003, Annals of the New York Academy of Sciences.
[29] R. Benezra,et al. Id proteins in development, cell cycle and cancer. , 2003, Trends in cell biology.
[30] E. Louis,et al. TOXICOKINETICS OF TREMOROGENIC NATURAL PRODUCTS, HARMANE AND HARMINE, IN MALE SPRAGUE-DAWLEY RATS , 2001, Journal of toxicology and environmental health. Part A.
[31] Y. Yokota. Id and development , 2001, Oncogene.
[32] D. Nutt,et al. β-carboline binding to imidazoline receptors , 2001 .
[33] R. Glennon,et al. Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors , 2000 .
[34] T. Sourkes,et al. "Rational hope" in the early treatment of Parkinson's disease. , 1999, Canadian journal of physiology and pharmacology.
[35] Ahmed Mansouri,et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2 , 1999, Nature.
[36] J. Woo,et al. Ca2+-ATPase inhibitors and Ca2+-ionophore induce osteoclast-like cell formation in the cocultures of mouse bone marrow cells and calvarial cells. , 1997, Biochemical and biophysical research communications.
[37] H. Yatani,et al. A Small-molecule Approach to Bone Regenerative Medicine in Dentistry , 2010 .
[38] D. Nutt,et al. beta-carboline binding to imidazoline receptors. , 2001, Drug and alcohol dependence.
[39] R. Glennon,et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. , 2000, Drug and alcohol dependence.
[40] H. Joost,et al. Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. , 1999, Progress in nucleic acid research and molecular biology.
[41] R. Ramsay,et al. Inhibition of Monoamine Oxidase A by β-Carboline Derivatives , 1997 .