Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium.

[1]  Zhiqian Sun,et al.  Trehalose alleviates apoptosis by protecting the autophagy-lysosomal system in alveolar macrophages during human silicosis. , 2020, Life sciences.

[2]  Ying Chen,et al.  Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages , 2020, Cells.

[3]  M. Peitsch,et al.  Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond , 2019, Critical reviews in toxicology.

[4]  Seung-Jae Lee,et al.  Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction , 2018, Cell Death & Disease.

[5]  Detlef Ritter,et al.  Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations , 2018, Applied in vitro toxicology.

[6]  Piyush Mehta,et al.  Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering , 2018, Journal of drug delivery.

[7]  Joy L. Hart,et al.  Generally Recognized as Safe: Uncertainty Surrounding E-Cigarette Flavoring Safety , 2017, International journal of environmental research and public health.

[8]  D. Baines,et al.  Airway Glucose Homeostasis: A New Target in the Prevention and Treatment of Pulmonary Infection , 2017, Chest.

[9]  A. Ballabio,et al.  Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis , 2017, Nature Communications.

[10]  M. Amiri,et al.  Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity , 2017, The Journal of Biological Chemistry.

[11]  G. Ahearn,et al.  Functional characterization of a novel disaccharide transporter in lobster hepatopancreas , 2017, Journal of Comparative Physiology B.

[12]  J. Crowley,et al.  SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy , 2016, Scientific Reports.

[13]  Julia Hoeng,et al.  3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product. , 2016, ALTEX.

[14]  J. Crowley,et al.  Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis , 2016, Science Signaling.

[15]  Oliver Eickelberg,et al.  Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured in air-liquid interface conditions. , 2014, American journal of respiratory cell and molecular biology.

[16]  J. Hedrick,et al.  Trehalose glycopolymers as excipients for protein stabilization. , 2013, Biomacromolecules.

[17]  W. Lipkin,et al.  Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances , 2011, PloS one.

[18]  Heiko Meyer,et al.  Identification of an animal sucrose transporter , 2011, Journal of Cell Science.

[19]  Satoshi Ohtake,et al.  Trehalose: current use and future applications. , 2011, Journal of pharmaceutical sciences.

[20]  K. Rahmouni,et al.  Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways , 2011, PloS one.

[21]  Robert Combes,et al.  In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. , 2009, Alternatives to laboratory animals : ATLA.

[22]  J. Buts,et al.  Characterization of α,α-trehalase released in the intestinal lumen by the probiotic Saccharomyces boulardii , 2008, Scandinavian journal of gastroenterology.

[23]  S. Taketani,et al.  Molecular cloning, sequencing and expression of cDNA encoding human trehalase. , 1997, Gene.

[24]  H. Holzhütter,et al.  Use of mathematical models for predicting the metabolic effect of large-scale enzyme activity alterations. Application to enzyme deficiencies of red blood cells. , 1995, European journal of biochemistry.

[25]  R. Levin,et al.  Digestion and absorption of carbohydrates--from molecules and membranes to humans. , 1994, The American journal of clinical nutrition.

[26]  Walter Hayduk,et al.  Prediction of diffusion coefficients for nonelectrolytes in dilute aqueous solutions , 1974 .

[27]  S J Enna,et al.  Absorption of saccharides and urea from the rat lung. , 1972, The American journal of physiology.

[28]  M. Sleisenger,et al.  Metabolism of circulating disaccharides in man and the rat. , 1967, The Journal of clinical investigation.

[29]  Jian Li,et al.  Lactose induced redox-dependent senescence and activated Nrf2 pathway. , 2019, International journal of clinical and experimental pathology.

[30]  Yang Xiang,et al.  Generalized Simulated Annealing for Global Optimization: The GenSA Package , 2013, R J..

[31]  M. Kohlmeier.  How Nutrients are Affected by Genetics , 2013 .

[32]  S. Underwood,et al.  Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[33]  S. Schmidt,et al.  Water activity and solubility of trehalose , 1998 .

[34]  G. Galand,et al.  Brush border membrane sucrase-isomaltase, maltase-glucoamylase and trehalase in mammals. Comparative development, effects of glucocorticoids, molecular mechanisms, and phylogenetic implications. , 1989, Comparative biochemistry and physiology. B, Comparative biochemistry.

[35]  A. Elbein.  The Metabolism of a,a-Trehalose , 1974 .