In recent years, the denoising of low-frequency desert noise has been the significant and difficult point in processing seismic data. Traditional random noise suppression methods could not get a good result in processing seismic data in desert areas. Moreover, convolutional neural network (CNN) has made notable achievements in many fields recently. In order to denoise seismic data in desert areas and improve the signal-to-noise ratio (SNR), CNN is introduced to process seismic data. According to the characteristics of desert seismic data, we designed a new network suitable for desert seismic data training and denoising, which is named DnResNeXt. Then, to form a mapping from the noisy data to the pure desert noise, we build a mass of training sets to train the denoising network. Thus, the network can predict the noise, then by subtracting the predicted noise from the noisy data, the denoised data are obtained. Consequently, compared with the traditional methods in suppressing random noise, DnResNeXt network has obvious advantages in both simulation and actual experiments.